Abstract: The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.

Abstract: The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.

Abstract: A therapy system includes a therapy source (2) emitting radiation or waves, an ultrasound probe (14), a patient rest as well as a multi-axis positioning system (X, Y, Z) with several drives, by way of which the patient rest and the therapy source (2) can be moved to one another in all three spatial directions. A control device (26) is coupled to the ultrasound probe (14) and configured such that in at least one operating mode, the control device (26) simultaneously activates the drives of the multi-axis positioning system (X, Y, Z) such that the patient rest is moved relative to the therapy source along a selectable movement path (B) which lies within the plane of an ultrasound picture (20) which is currently recorded by the ultrasound probe (14). A method for positioning a patient rest relative to a therapy source is also provided.

Abstract: A therapy system includes a therapy source (2) emitting radiation or waves, an ultrasound probe (14), a patient rest as well as a multi-axis positioning system (X, Y, Z) with several drives, by way of which the patient rest and the therapy source (2) can be moved to one another in all three spatial directions. A control device (26) is coupled to the ultrasound probe (14) and configured such that in at least one operating mode, the control device (26) simultaneously activates the drives of the multi-axis positioning system (X, Y, Z) such that the patient rest is moved relative to the therapy source along a selectable movement path (B) which lies within the plane of an ultrasound picture (20) which is currently recorded by the ultrasound probe (14). A method for positioning a patient rest relative to a therapy source is also provided.

Abstract: Winding crown for a timepiece, said crown (40) including a bottom (42) and a skirt (44), which delimits an inner volume housing at least one elastically deformable element, the crown (40) being characterized in that a stop member is inserted between the elastically deformable element (50) and the bottom (42) of the crown (40) to prevent any surface contact between said elastically deformable element (50) and said bottom (42).

Abstract: Winding crown for a timepiece, said crown (32) including an uncoupling mechanism (1) comprising a rigid drive ring (4, 400) secured to the crown (32) and cooperating with at least one elastically deformable element (2; 200) secured to a pipe (12) to one end of which a winding stem is secured, the rigid ring (4; 400) driving the deformable elastic element (2; 200) in at least one rotational direction until the resistant torque opposed by said elastic element (2; 200) exceeds a threshold value beyond which said elastic element (2; 200) is deformed so as to interrupt the drive connection thereof with the rigid ring (4; 400), the elastically deformable element (2; 200) therefore having means for temporary coupling said element to said rigid drive ring (4; 400), the crown (32)) being characterized in that the elastically deformable element (2; 200) includes means for centering said element relative to the rigid drive ring (4; 400).

Abstract: Winding crown for a timepiece, said crown (40) including a bottom (42) and a skirt (44), which delimits an inner volume housing at least one elastically deformable element, the crown (40) being characterized in that a stop member is inserted between the elastically deformable element (50) and the bottom (42) of the crown (40) to prevent any surface contact between said elastically deformable element (50) and said bottom (42).

Abstract: Winding crown for a timepiece, said crown (32) including an uncoupling mechanism (1) comprising a rigid drive ring (4, 400) secured to the crown (32) and cooperating with at least one elastically deformable element (2; 200) secured to a pipe (12) to one end of which a winding stem is secured, the rigid ring (4; 400) driving the deformable elastic element (2; 200) in at least one rotational direction until the resistant torque opposed by said elastic element (2; 200) exceeds a threshold value beyond which said elastic element (2; 200) is deformed so as to interrupt the drive connection thereof with the rigid ring (4; 400), the elastically deformable element (2; 200) therefore having means for temporary coupling said element to said rigid drive ring (4; 400), the crown (32)) being characterized in that the elastically deformable element (2; 200) includes means for centring said element relative to the rigid drive ring (4; 400).

Abstract: Winding crown for a timepiece, said crown (32) including an uncoupling mechanism (1) comprising a rigid drive ring (4, 400) secured to the crown (32) and cooperating with at least one elastically deformable element (2; 200) secured to a pipe (12) to one end of which a winding stem is secured, the rigid ring (4; 400) driving the deformable elastic element (2; 200) in at least one rotational direction until the resistant torque opposed by said elastic element (2; 200) exceeds a threshold value beyond which said elastic element (2; 200) is deformed so as to interrupt the drive connection thereof with the rigid ring (4; 400), the elastically deformable element (2; 200) therefore having means for temporary coupling said element to said rigid drive ring (4; 400), the crown (32)) being characterized in that the elastically deformable element (2; 200) includes means for centring said element relative to the rigid drive ring (4; 400).

Abstract: The medical therapy device includes at least one picture-providing locating device, a treatment device, a patient rest, means for the motorized positioning of at least the treatment device relative to the patient rest, means for control of the therapy device, and a display and operating device. The treatment center of the treatment device may be represented on the display in at least one picture of the locating device on the display, and operating elements are provided, with which the positioning in coordinates of the locating device may be controlled.

Abstract: Crown for a timepiece, said crown (1) including a cap (2) extended by a skirt (4) which delimits a hollow inner housing (6), said crown (1) being characterized in that an at least partially transparent cover (14) is mounted in the cap (2), said cover (14) revealing all or part of a device (18) arranged in the hollow inner housing (6) of the crown (1).

Abstract: Winding crown for a timepiece, said crown (32) including an uncoupling mechanism (1) comprising a rigid drive ring (4, 400) secured to the crown (32) and cooperating with at least one elastically deformable element (2; 200) secured to a pipe (12) to one end of which a winding stem is secured, the rigid ring (4; 400) driving the deformable elastic element (2; 200) in at least one rotational direction until the resistant torque opposed by said elastic element (2; 200) exceeds a threshold value beyond which said elastic element (2; 200) is deformed so as to interrupt the drive connection thereof with the rigid ring (4; 400), the elastically deformable element (2; 200) therefore having means for temporary coupling said element to said rigid drive ring (4; 400), the crown (32)) being characterized in that the elastically deformable element (2; 200) includes means for centring said element relative to the rigid drive ring (4; 400).

Abstract: The present invention concerns a crown for a timepiece comprising a disconnecting gear device for preventing damage to the components of the movement of the timepiece in which it is implemented. For this purpose, the crown is provided with a housing which houses a pipe, to which one end of a winding stem is connected, carrying at least one spring and a rigid ring secured to the crown and comprising notches adapted to cooperate with the spring. In common use, a rotation of the crown causes a rotation of the pipe and thus of the winding stem, via the rigid ring and the spring. Owing to the device according to the present invention, when the mechanical resistance to the rotation opposed by the winding stem, via the pipe, exceeds a predefined threshold, the spring is deformed and is no longer driven in rotation by the rigid ring. Consequently, the winding stem is no longer driven in rotation in such conditions.

Abstract: The present invention concerns a crown for a timepiece comprising a disconnecting gear device for preventing damage to the components of the movement of the timepiece in which it is implemented. For this purpose, the crown is provided with a housing which houses a pipe, to which one end of a winding stem is connected, carrying at least one spring and a rigid ring secured to the crown and comprising notches adapted to cooperate with the spring. In common use, a rotation of the crown causes a rotation of the pipe and thus of the winding stem, via the rigid ring and the spring. Owing to the device according to the present invention, when the mechanical resistance to the rotation opposed by the winding stem, via the pipe, exceeds a predefined threshold, the spring is deformed and is no longer driven in rotation by the rigid ring. Consequently, the winding stem is no longer driven in rotation in such conditions.