Patents by Inventor Georgi Graschew

Georgi Graschew has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5622685
    Abstract: Tumor-active or tumor-diagnostic substances having preferred accumulation in the tumor, which are characterized in that they haveat least two phenolic hydroxyl and/or amino groups,at least one aliphatic amino group, orat least one phenolic hydroxyl and/or amino group andat least one aliphatic amino groupand that these groups are substituted with polyethylene glycol chains whose polymerization degree n is 5 to 250 and whose terminal hydroxyl group is substituted by C.sub.1 -C.sub.12 alkyl ester or ether, each of the substances being substituted by at least two such polyethylene glycol chains.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 22, 1997
    Assignee: Deutches Krebsforchunszentrum Stiftung des Offentlichen Rechts
    Inventors: Hans J. Sinn, Hans-Hermann Schrenk, Wolfgang Maier-Borst, Eckhard Friedrich, Georgi Graschew, Dieter Wohrle, Thomas Klenner
  • Patent number: 5308604
    Abstract: The invention relates to conjugates composed ofa) at least one polyalcohol or a derivatized polyalcohol,b) at least one active agent,c) at least one linker andd) a protein,wherein the polyalcohol(s) or the derivatized polyalcohol(s) are polyalcohols or derivatized polyalcohols which are not recognized by the defense system of an organism as exogenous, and the protein is a protein which can be taken up by the tumor specifically or non-specifically, and is not recognized by the defense system of an organism as exogenous. These conjugates are suitable for, on the one hand, making possible a very sensitive method in nuclear medicine for the diagnosis of tumors and, on the other hand, for example also offering new methods for diagnosing tumors in X-ray diagnosis, computerized tomography, nuclear spin tomography, electron spin resonance spectroscopy or electron microscopy.
    Type: Grant
    Filed: March 26, 1992
    Date of Patent: May 3, 1994
    Assignee: Deutsches Krebsforschungsinstitut
    Inventors: Hansjorg Sinn, Hans-Hermann Schrenk, Wolfgang Maier-Borst, Eckhard Friedrich, Georgi Graschew, Dieter Worhle
  • Patent number: 4606128
    Abstract: A caliper for soft objects such as tumor tissue has a pair of contact plates on respective members of which at least one is movable so that the object can be embraced between the contact plates. The instrument has a visual display of the contact pressure, an electrical display of the contact pressure or a locking mechanism establishing the contact pressure for reproducible measurement.
    Type: Grant
    Filed: August 29, 1985
    Date of Patent: August 19, 1986
    Assignee: KFA - Kernforschungsanlage Julich GmbH
    Inventors: Helmut Wyrwich, Georgi Graschew, Johann Chatzipetros, Ludwig E. Feinendegen
  • Patent number: 4599800
    Abstract: A caliper for soft objects such as tumor tissue has a pair of contact plates on respective members of which at least one is movable so that the object can be embraced between the contact plates. The instrument has a visual display of the contact pressure, an electrical display of the contact pressure or a locking mechanism establishing the contact pressure for reproducible measurement.
    Type: Grant
    Filed: May 21, 1984
    Date of Patent: July 15, 1986
    Assignee: KFA--Kernforschungsanlage Julich GmbH
    Inventors: Helmut Wyrwich, Georgi Graschew, Johann Chatzipetros, Ludwig E. Feinendegen