Patents by Inventor Georgia Hatzivassiliou

Georgia Hatzivassiliou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF CBP/EP300 BROMODOMAIN INHIBITORS FOR CANCER IMMUNOTHERAPY
    Publication number: 20160317632
    Abstract: The present invention relates to use of CBP/EP300 bromodomain inhibitors for the treatment of cancer.
    Type: Application
    Filed: April 11, 2016
    Publication date: November 3, 2016
    Applicants: GENENTECH, INC., CONSTELLATION PHARMACEUTICALS, INC.
    Inventors: Brian K. Albrecht, James Edmund Audia, Steven Bellon, Andrea Cochran, Alexandre Cote, Terry Crawford, Benjamin Fauber, Srimoyee Ghosh, Jean-Christophe Harmange, Georgia Hatzivassiliou, Hariharan Jayaram, Jeong Kim, Jose M. Lora, Steven Magnuson, Ira Mellman, Anthony F. Romero, Alexander M. Taylor, Vickie Tsui
  • Compositions and methods for treating cancer
    Patent number: 9060993
    Abstract: Methods of treating individuals identified as having cancer using ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of inducing apoptosis in cancer cells using an ATP citrate lyase inhibitor and/or tri-carboxylate transporter inhibitor are disclosed. of treating an individual who has cancer comprising the steps of identifying the cancer as having a high rate of aerobic glycolysis, and administering an ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of treating individuals who have cancer using compounds that inhibit the expression of ATP citrate lyase or tricarboxylate transporter are disclosed. Methods of identifying a compound with anticancer activity are disclosed.
    Type: Grant
    Filed: May 7, 2004
    Date of Patent: June 23, 2015
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Craig B. Thompson, Daniel Bauer, Georgia Hatzivassiliou
  • DETERMINING SENSITIVITY OF CELLS TO B-RAF INHIBITOR TREATMENT BY DETECTING KRAS MUTATION AND RTK EXPRESSION LEVELS
    Publication number: 20150164895
    Abstract: The present invention relates to prognostic methods for identifying tumors that are not susceptible to B-Raf inhibitor treatment by detecting mutations in a K-ras gene or protein or by detecting overexpression of RTKs and/or their ligands. Kits are also disclosed for carrying out the methods.
    Type: Application
    Filed: May 21, 2014
    Publication date: June 18, 2015
    Applicant: GENENTECH, INC.
    Inventors: Georgia Hatzivassiliou, Shiva Malek
  • DETERMINING SENSITIVITY OF CELLS TO B-RAF INHIBITOR TREATMENT BY DETECTING KRAS MUTATION AND RTK EXPRESSION LEVELS
    Publication number: 20120214828
    Abstract: The present invention relates to prognostic methods for identifying tumors that are not susceptible to B-Raf inhibitor treatment by detecting mutations in a K-ras gene or protein or by detecting overexpression of RTKs and/or their ligands. Kits are also disclosed for carrying out the methods.
    Type: Application
    Filed: August 24, 2010
    Publication date: August 23, 2012
    Inventors: Georgia Hatzivassiliou, Shiva Malek
  • Compositions and methods for treating cancer
    Publication number: 20070259956
    Abstract: Methods of treating individuals identified as having cancer using ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of inducing apoptosis in cancer cells using an ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of treating an individual who has cancer comprising the steps of identifying the cancer as having a high rate of aerobic glycolysis, and administering an ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of treating individuals who have cancer using compounds that inhibit the expression of ATP citrate lyase or tricarboxylate transporter are disclosed. Methods of identifying a compound with anticancer activity are disclosed.
    Type: Application
    Filed: May 7, 2004
    Publication date: November 8, 2007
    Inventors: Craig Thompson, Daniel Bauer, Georgia Hatzivassiliou