Patents by Inventor Georgina Gurrola Briones

Georgina Gurrola Briones has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vm23 and Vm24, two scorpion peptides that block human T-lymphocyte potassium channels (sub-type Kv1.3) with high selectivity and decrease the in vivo DTH-responses in rats
    Patent number: 8394770
    Abstract: Potassium channels Kv1.3 are known to be implicated in immunological diseases and graft rejections. Disclosed are peptides capable of blocking with high affinity and specificity potassium channels Kv1.3, their pharmaceutical compositions, and methods for their use to block Kv1.3 potassium channels, to treat various immunological conditions and to diagnostic applications. Methods for their chemical synthesis and correct folding are also disclosed. Exemplary peptides correspond to protein components (Vm23 and Vm24) isolated from the venom of the Mexican scorpion Vaejovis mexicanus smithi. Vm23 and Vm24 bind to hKv1.3 channels in an almost irreversible manner, showing a Kd value in the order of 3 picomolar range, when applied to human lymphocytes cultures in vitro. Vm24 was chemically synthesized and used in in vivo experiments to successfully treat sensitized rats (on the DTH-response).
    Type: Grant
    Filed: May 14, 2007
    Date of Patent: March 12, 2013
    Assignee: Universidad Nacional Autonoma de Mexico
    Inventors: Lourival Domingos Possani-Postay, Georgina Gurrola-Briones, Saida Patricia Salas-Castillo, César Vicente Ferreira Batista, Zoltán S. Varga, György Panyi, Rezsö Gáspár
  • Vm23 and Vm24, two scorpion peptides that block human T-lymphocyte potassium channels (sub-type Kv1.3) w/High Selectivity and Decrease the in vivo DTH-responses in Rats
    Publication number: 20110059064
    Abstract: Potassium channels Kv1.3 are known to be implicated in immunological diseases and graft rejections. Disclosed are peptides capable of blocking with high affinity and specificity potassium channels Kv1.3, their pharmaceutical compositions, and methods for their use to block Kv1.3 potassium channels, to treat various immunological conditions and to diagnostic applications. Methods for their chemical synthesis and correct folding are also disclosed. Exemplary peptides correspond to protein components (Vm23 and Vm24) isolated from the venom of the Mexican scorpion Vaejovis mexicanus smithi. Vm23 and Vm24 bind to hKv1.3 channels in an almost irreversible manner, showing a Kd value in the order of 3 picomolar range, when applied to human lymphocytes cultures in vitro. Vm24 was chemically synthesized and used in in vivo experiments to successfully treat sensitized rats (on the DTH-response).
    Type: Application
    Filed: May 14, 2007
    Publication date: March 10, 2011
    Inventors: Lourival Domingos Possani-Postay, Georgina Gurrola-Briones, Saida Patricia Salas-Castillo, César Vicente Ferreira Batista, Zoltán S. Varga, György Panyi, Rezsö Gáspár
  • Recombinant immunogens for the generation of antivenoms to the venom of scorpions of the genus
    Patent number: 7335759
    Abstract: The invention concerns genes and fusion of genes that code for scorpion toxins and the corresponding polypeptides. The invention also concerns the use of the polypeptides as immunogens for the generation of antibodies that can recognize and neutralize components of scorpion venom as well as for vaccines to prevent envenomation from stings of scorpions of the genus Centruroides, and to immunogenic matrices for the purification of specific immunoglobulins.
    Type: Grant
    Filed: November 26, 2003
    Date of Patent: February 26, 2008
    Assignee: Universidad Nacional Autónoma de Méxica (UNAM)
    Inventors: Miguel Corona Villegas, Ma Consuelo Garcia Rodríguez, Georgina Gurrola Briones, Norma Adriana Valdez Cruz, Baltazar Becerril Luján, Lourival Domingos Possani Postay
  • Recombinant immunogens for the generation of antivenoms to the venom of scorpions of the genus Centruroides
    Publication number: 20050065331
    Abstract: The invention concerns genes and fusion of genes that code for scorpion toxins and the corresponding polypeptides. The invention also concerns the use of the polypeptides as immunogens for the generation of antibodies that can recognize and neutralize components of scorpion venom as well as for vaccines to prevent envenomation from stings of scorpions of the genus Centruroides, and to immunogenic matrices for the purification of specific immunoglobulins.
    Type: Application
    Filed: November 26, 2003
    Publication date: March 24, 2005
    Inventors: Miguel Corona Villegas, Ma Garcia Rodriguez, Georgina Gurrola Briones, Norma Valdez Cruz, Baltazar Becerril Lujan, Lourival Possani Postay