Abstract: The invention concerns new topical anti-inflammatory 1-phenyl-2-aminoethanol derivatives of the general formula:R.sup.1 .multidot.CH(OH).multidot.CH.sub.2 NH.multidot.CR.sup.2 R.sup.3 .multidot.A.sup.1 .multidot.NH[CO.multidot.Y.multidot.NH].sub.n .multidot.Qwherein R.sup.1 is a phenyl bearing specific combinations of (2-12C)alkanoyloxy,[(2-12C)alkanoyloxy]methyl,chloro and amino substituents, R.sup.2 and R.sup.3 are independently hydrogen or (1-4C)alkyl, A.sup.1 is a (1-4C)alkylene, Y is a (1-4C)alkylene optionally bearing a (1-4C)alkyl or benzyl, n is an integer from 1 to 4, and Q is an optionally substituted benzoyl, phenylacetyl, or phenoxyacetyl together with the acid-addition salts thereof; and the pharmaceutical compositions thereof, for use in the treatment of inflammatory skin diseases and conditions. The invention also concerns processes for the manufacture of derivatives of formula I.

Abstract: Pharmaceutical compositions, containing a 4,4'-dihydroxy-3,3'-triphenylmethanedicarboxylic acid (or an oxidized derivative) as active ingredient, are described and are prepared conventionally in a form suitable for topical administration e.g. ointment. The compositions are useful for the treatment of inflammatory diseases and inflammatory conditions of the skin. Many of the active ingredients are novel compounds. A representative novel active ingredient is 4"-cyano-4,4'-dihydroxy-5,5'-dimethyl-3,3'-triphenylmethanedicarboxylic acid.

Abstract: Pharmaceutical compositions, containing a 4,4'-dihydroxy-3,3'-triphenylmethanedicarboxylic acid (or an oxidized derivative) as active ingredient, are described and are prepared conventionally in a form suitable for topical administration, e.g., ointment. The compositions are useful for the treatment of inflammatory diseases and inflammatory conditions of the skin. Many of the active ingredients are novel compounds. A representative novel active ingredient is 4"-cyano-4,4'-dihydroxy-5,5'-dimethyl-3,3'-triphenylmethanedicarboxylic acid.

Abstract: Optionally substituted 4-oxo-1,4-dihydrocinnolin-3-ylpropionic acid derivatives, processes for their preparation, pharmaceutical compositions containing them, and a method of treatment using them. A representative compound is ethyl 6-ethyl-1-methyl-4-oxo-1,4-dihydrocinnolin-3-ylpropionate. Compounds active as inhibitors of effects following the combination of reagin-like antibodies and their antigens.