Patents by Inventor Gerald A. Fink

Gerald A. Fink has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11041161
    Abstract: Metabolic flux biosensors are provided herein, as are related compositions and methods useful for, inter alia, identifying factors which increase the production of metabolites and/or end products of metabolic pathways, and for the production of inter alia, metabolites and/or end products of metabolic pathways.
    Type: Grant
    Filed: January 8, 2015
    Date of Patent: June 22, 2021
    Assignees: Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology
    Inventors: Jose Luis Avalos, Gerald Fink, Gregory Stephanopoulos
  • Publication number: 20160326535
    Abstract: Metabolic flux biosensors are provided herein, as are related compositions and methods useful for, inter alia, identifying factors which increase the production of metabolites and/or end products of metabolic pathways, and for the production of inter alia, metabolites and/or end products of metabolic pathways.
    Type: Application
    Filed: January 8, 2015
    Publication date: November 10, 2016
    Applicants: Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology
    Inventors: Jose Luis Avalos, Gerald Fink, Gregory Stephanopoulos
  • Publication number: 20150072391
    Abstract: The present disclosure provides, in various aspects, engineered alcohol tolerant yeast and methods of producing high concentrations of ethanol.
    Type: Application
    Filed: September 5, 2014
    Publication date: March 12, 2015
    Applicants: Massachusetts Institute of Technology, Whitehead Institute for Biomedical Research
    Inventors: Felix Lam, Gerald Fink, Gregory Stephanopoulos
  • Publication number: 20120309073
    Abstract: The invention provides budding yeast that have a functional RNAi pathway. The invention provides RNAi pathway polypeptides derived from budding yeast that have an endogenous RNAi pathway. In some embodiments the invention provides functional budding yeast Dicer polypeptides and variants thereof. In some embodiments the invention provides functional budding yeast Argonaute polypeptides and variants thereof. Also provided are isolated nucleic acids encoding the polypeptides of the invention, vectors comprising such nucleic acids, and methods of making the polypeptides and nucleic acids. The invention further provides genetically engineered cells that comprise a functional RNAi pathway polypeptide derived from budding yeast. In some embodiments such cells lack a functional endogenous RNAi pathway and are genetically engineered to have a functional RNAi pathway by introducing nucleic acid(s) encoding one or more functional RNAi pathway polypeptides derived from budding yeast.
    Type: Application
    Filed: September 10, 2010
    Publication date: December 6, 2012
    Applicants: Whitehead Institute for Biomedical Research, of Queen Elizabeth Near Dublin
    Inventors: David P. Bartel, Ines A. Drinnenberg, David E. Weinberg, Kathleen T. Xie, Kenneth H. Wolfe, Gerald Fink
  • Publication number: 20100291648
    Abstract: The invention relates to global transcription machinery engineering to produce altered cells having improved phenotypes.
    Type: Application
    Filed: December 7, 2007
    Publication date: November 18, 2010
    Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH
    Inventors: Hal S. Alper, Gregory Stephanopoulos, Gerald Fink
  • Publication number: 20080104733
    Abstract: The present invention relates to a transgenic plant which is tolerant to a salt, comprising one or more plant cells transformed with exogenous nucleic acid which alters expression of vacuolar pyrophosphatase in the plant. The present invention also relates to a transgenic plant with increased Pi uptake, comprising one or more plant cells transformed with exogenous nucleic acid which alters expression of vacuolar pyrophosphatase in the plant. Also encompassed by the present invention are transgenic progeny and seeds of the transgenic plants described herein. Progeny transgenic plant grown from seed are also described. Plant cells (e.g., root cells, stem cell, leaf cells, flower cells, fruit cells and seed cells) comprising exogenous nucleic acid which alters expression of vacuolar pyrophosphatase in the plant cell are also the subject of the present invention. Also encompassed by the present invention are methods of making a transgenic plant described herein.
    Type: Application
    Filed: August 7, 2007
    Publication date: May 1, 2008
    Inventors: Roberto Gaxiola, Gerald Fink, Seth Alper
  • Publication number: 20050278808
    Abstract: Methods are provided for imparting desirable pohenotypic traits to transgenic plants, among them being increased tolerance to external stresses such as drought, freezing temperatures, high salt conditions, and the like. In addition, the present invention is directed toward methods for increasing the yield of seeds from plants by using the pollen from a transgenic plant transformed to overexpress a vacuolar proton-pumping pyrophosphatase to fertilize plants, and to the pollen of transgenic plants itself.
    Type: Application
    Filed: May 23, 2005
    Publication date: December 15, 2005
    Inventors: Roberto Gaxiola, Seth Alper, Gerald Fink
  • Publication number: 20050262598
    Abstract: The present invention relates to a transgenic plant which is tolerant to a salt, comprising one or more plant cells transformed with exogenous nucleic acid which alters expression of vacuolar pyrophosphatase in the plant. Also encompassed by the present invention are transgenic progeny and seeds of the transgenic plants described herein. Progeny transgenic plant grown from seed are also described. The present invention also relates to a construct comprising an AVP1 gene operably linked to a chimeric promoter designed to overexpress AVP1 or designed to down regulate endogenous pyrophosphatase. Plant cells (e.g., root cells, stem cell, leaf cells) comprising exogenous nucleic acid which alters expression of vacuolar pyrophosphatase in the plant cell are also the subject of the present invention. Also encompassed by the present invention are methods of making a transgenic plant described herein.
    Type: Application
    Filed: May 2, 2005
    Publication date: November 24, 2005
    Inventors: Roberto Gaxiola, Gerald Fink, Seth Alper
  • Patent number: 6174062
    Abstract: In an adjustable rearview mirror, especially an outside mirror, for a motor vehicle, whereby a first element (1) is affixable to the vehicle and a second element (2), rotatably attached to the first element (1), has or forms a mount for a mirror (4), whereby the two elements (1, 2) are designed as dish-shaped elements (1, 2) that nest with one another at least partially and are guided or bear against one another via outside and inside areas of contact forming a segment of a spherical surface and whereby a drive (6) is provided between the first and the second element (1, 2) is proposed, characterized in that the outer element (2) is designed on part of its inner surface with a gear-tooth system extending along a circular section of the inner surface of the outer element (2), with which a pinion (8) of a drive (6) mounted in the inside of the inner element (1) meshes for adjustment of the outer element (2) relative to the inner element (1), by which means can be achieved with a simple construction a design tha
    Type: Grant
    Filed: September 11, 1998
    Date of Patent: January 16, 2001
    Assignee: Magna Auteca Zweigniederlassung der Magna Holding AG
    Inventors: Peter Schillegger, Gerald Fink, Wolfgang Pacher
  • Patent number: 4946102
    Abstract: Vehicular apparatus for spraying herbicides and insecticides has a supporting frame for being carried by a truck or trailer. Upright supports are carried by the frame and trailing boom supports extend rearwardly from the upright supports, which carry structure for selective pivoting of the trailing boom supports relative to the upright supports to permit vertical adjustability of the spray. Lateral booms are supported by the trailing boom supports and connected to them such that the lateral booms can pivot relative to the trailing boom supports and ground. The lateral booms include a supporting base section, a mid-section, and a boom tip section. At least the tip section of the lateral boom includes spray nozzles for selective liquid spraying. A pivotal connector connects and provides forward and backward horizontal pivotal movement of the boom mid-sections relative to the boom base sections.
    Type: Grant
    Filed: July 3, 1989
    Date of Patent: August 7, 1990
    Inventors: Carl DeWitt, Gerald A. Fink
  • Patent number: 4784324
    Abstract: Apparatus for spraying of liquids for herbicidal and insecticidal application and the like has a supporting frame for being carried by a vehicle. An upright support is carried by the frame including an upright post and includes a hydraulic cylinder for providing selective vertical telescoping movement of the post. A hydraulic cylinder provides rotation of the post, for rotating a boom carried by the post. A hydraulic cylinder also provides selective pivoting of the supporting boom section relative to the post for vertical movement. The boom has a supporting boom section, a mid-boom section and a reconfigurable boom end element which may be either an articulating tip boom section or a strip spray attachment of "wishbone" configuration. A hydraulic motor provides selective telescoping movement of the mid-boom section relative to the supporting boom sections. The supporting boom section, mid-boom section and boom end element all include spray nozzles.
    Type: Grant
    Filed: January 7, 1988
    Date of Patent: November 15, 1988
    Inventors: Carl DeWitt, Gerald A. Fink
  • Patent number: 4697405
    Abstract: A mower for mowing under fences or guardrails and the like has trailer mounted multiple rotary mower units including a first multiple blade unit for rotating on a vertical axis around posts and for mowing under and behind the fence or guardrail and a single rotary mower unit for mowing under the fence or guardrail on the inside. Both units having vertical and horizontal movements to desired positions adjacent to and under the guardrail or fence. The trailer is steered automatically parallel to the fence or guardrail being mown by a spring-loaded steering axle and steering linkage including a pressure wheel running against the guardrail or fence. The inside and outside mowers can be rotated into travel positions so the entire unit can be towed by tractor, truck, or other vehicle upon highways.
    Type: Grant
    Filed: December 24, 1985
    Date of Patent: October 6, 1987
    Inventors: Carl DeWitt, Gerald A. Fink
  • Patent number: D357766
    Type: Grant
    Filed: May 19, 1993
    Date of Patent: April 25, 1995
    Assignee: Celeste Company, Inc.
    Inventors: Jack H. Prince, Gerald Fink
  • Patent number: D362922
    Type: Grant
    Filed: November 12, 1993
    Date of Patent: October 3, 1995
    Assignee: Celeste Company, Inc.
    Inventors: Jack H. Prince, Gerald Fink, Richard B. Caruso