Abstract: The present disclosure relates to a site-specific integration (SSI) mammalian cell that comprises at least two distinct recombination target sites (RTS) wherein two RTS are chromosomally-integrated within the NL1 locus or the NL2 locus. The disclosure also relates to a SSI mammalian cell comprising at least four distinct RTS wherein two RTS are chromosomally-integrated within the NL1 or the NL2 locus and two RTS are chromosomally-integrated within a separate locus. The disclosure also relates to methods for using the SSI mammalian cell to produce recombinant protein expression cell lines that can express difficult to express proteins.

Abstract: In a computing system having virtualization software including a guest operating system (OS), a method for executing guest OS instructions that includes: replacing each of one or more guest OS instructions with: (a) a translated instruction, which translated instruction is a one-to-one translation, or (b) a trap instruction.

Abstract: The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to P-cadherin, and that function to inhibit P-cadherin. The invention also relates to heavy and light chain immunoglobulins derived from human P-cadherin antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human P-cadherin antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.

Abstract: A computing system includes virtualization software including a guest operating system (OS). A method maintains, by the virtualization software layer, a first shadow page table for use in a kernel mode and a second shadow page table for use in a user mode. The virtualization software switches between using the first shadow page table and the second shadow page table when the guest OS switches between operating in the kernel mode and the user mode.

Abstract: The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin ?5?1 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies or antigen binding portions thereof are also provided. The disclosure also provides methods for treating various cancers using the anti-?5?1 antibodies or antigen binding portions thereof described herein.

Abstract: A computing system includes virtualization software including a guest operating system (OS). A method maintains, by the virtualization software layer, a first shadow page table for use in a kernel mode and a second shadow page table for use in a user mode. The virtualization software switches between using the first shadow page table and the second shadow page table when the guest OS switches between operating in the kernel mode and the user mode.

Abstract: One or more embodiments provides a shadow page table used by a virtualization software wherein at least a portion of the shadow page table shares computer memory with a guest page table used by a guest operating system (OS) and wherein the virtualization software provides a mapping of guest OS physical pages to machine pages.

Abstract: In a computing system having virtualization software including a guest operating system (OS), a method for operating wherein virtualization software address space is distributed in guest OS address space that includes: granting the guest OS execute, but not read or write, access, to pages in the virtualization software address space.

Abstract: In a computing system having virtualization software including a guest operating system (OS), a method for providing page tables that includes: providing a guest page table used by the guest OS and a shadow page table and a shadow page directory used by the virtualization software wherein: at least a portion of the guest page table and the shadow page directory are the same; and the portions that are the same are shared in computer memory by the guest page table and the shadow page directory.

Abstract: One or more embodiments provides a shadow page table used by a virtualization software wherein at least a portion of the shadow page table shares computer memory with a guest page table used by a guest operating system (OS) and wherein the virtualization software provides a mapping of guest OS physical pages to machine pages.

Abstract: In a computing system having virtualization software including a guest operating system (OS), a method for providing page tables that includes: providing a guest page table used by the guest OS and a shadow page table used by the virtualization software wherein at least a portion of the guest page table and the shadow page table share computer memory.

Abstract: In a computing system having virtualization software including a guest operating system (OS), a method for providing page tables that includes: providing a guest page table used by the guest OS and a shadow page table used by the virtualization software wherein at least a portion of the guest page table and the shadow page table share computer memory; wherein: machine pages have a predetermined size; and the virtualization software maps guest OS physical pages to machine pages at a predetermined alignment.

Abstract: The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin ?5?1 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies or antigen binding portions thereof are also provided. The disclosure also provides methods for treating various cancers using the anti-?5?1 antibodies or antigen binding portions thereof described herein.

Abstract: The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to P-cadherin, and that function to inhibit P-cadherin. The invention also relates to heavy and light chain immunoglobulins derived from human P-cadherin antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human P-cadherin antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.

Abstract: The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to P-cadherin, and that function to inhibit P-cadherin. The invention also relates to heavy and light chain immunoglobulins derived from human P-cadherin antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human P-cadherin antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.

Abstract: In a computing system having virtualization software including a guest operating system (OS), a method for operating wherein virtualization software address space is distributed in guest OS address space that includes: granting the guest OS execute, but not read or write, access, to pages in the virtualization software address space.

Abstract: In a computing system having virtualization software including a guest operating system (OS), a method for providing page tables that includes: providing a guest page table used by the guest OS and a shadow page table and a shadow page directory used by the virtualization software wherein: at least a portion of the guest page table and the shadow page directory are the same; and the portions that are the same are shared in computer memory by the guest page table and the shadow page directory.

Abstract: In a computing system having virtualization software including a guest operating system (OS), a method for providing page tables that includes: providing a guest page table used by the guest OS and a shadow page table used by the virtualization software wherein at least a portion of the guest page table and the shadow page table share computer memory.

Abstract: In a computing system having virtualization software including a guest operating system (OS), a method for providing page tables that includes: providing a guest page table used by the guest OS and a shadow page table used by the virtualization software wherein at least a portion of the guest page table and the shadow page table share computer memory; wherein: machine pages have a predetermined size; and the virtualization software maps guest OS physical pages to machine pages at a predetermined alignment.

Abstract: In a computing system having virtualization software including a guest operating system (OS), a method for executing guest OS instructions that includes: replacing each of one or more guest OS instructions with: (a) a translated instruction, which translated instruction is a one-to-one translation, or (b) a trap instruction.