Patents by Inventor Gerald A. Rufo, Jr.

Gerald A. Rufo, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protease deletion
    Patent number: 5874278
    Abstract: A Bacillus cell contains a mutation in the epr gene resulting in inhibition of the production by the cell of the proteolytically active epr gene product; the cell may further contain mutations in the genes encoding proteolytically active residual protease I (RP-I) and proteolytically active residual protease II (RP-II) (mpr).
    Type: Grant
    Filed: April 15, 1997
    Date of Patent: February 23, 1999
    Assignee: OmniGene Inc.
    Inventors: Alan Sloma, Gerald A. Rufo, Jr., Cathy Faye Rudolph, Barbara J. Sullivan, Janice Pero
  • Protease deletion
    Patent number: 5620880
    Abstract: A Bacillus cell contains a mutation in the epr gene resulting in inhibition of the production by the cell of the proteolytically active epr gene product; the cell may further contain mutations in the genes encoding proteolytically active residual protease I (RP-I) and proteolytically active residual protease II (RP-II).
    Type: Grant
    Filed: September 7, 1990
    Date of Patent: April 15, 1997
    Assignee: Omnigene, Inc.
    Inventors: Alan Sloma, Gerald A. Rufo, Jr., Cathy F. Rudolph, Barbara J. Sullivan, Janice Pero
  • Protease deletion
    Patent number: 5589383
    Abstract: A Bacillus cell contains a mutation in the epr gene resulting in inhibition of the production by the cell of the proteolytically active epr gene product; the cell may further contain mutations in the genes encoding proteolytically active residual protease I (bpr) and proteolytically active residual protease II (RP-II).
    Type: Grant
    Filed: August 12, 1994
    Date of Patent: December 31, 1996
    Assignee: Omnigene, Inc.
    Inventors: Alan Sloma, Gerald A. Rufo, Jr., Cathy F. Rudolph, Barbara J. Sullivan, Janice Pero
  • Residual protease-III
    Patent number: 5294542
    Abstract: A Bacillus cell containing a mutation in the residual protease III (rp-III) gene resulting in the inhibition of the production by the cell of proteolytically active RP-III.
    Type: Grant
    Filed: March 19, 1991
    Date of Patent: March 15, 1994
    Assignee: Omnigene, Inc.
    Inventors: Alan Sloma, Gerald A. Rufo, Jr., Janice Pero
  • Expression of heterologous DNA using the bacillus coagulans amylase gene
    Patent number: 5171673
    Abstract: A vector for high-level expression of a heterologous gene in Bacillus, including a DNA sequence which encodes all or part of the structural gene and contains the promoter and ribosome binding site of a Bacillus coagulans amylase gene; within or immediately downstream of the structural gene is a site for insertion of heterologous DNA; when inserted, the heterologous DNA is in the same translational reading frame as the amylase gene; the heterologous DNA thus is under control of the B. coagulans amylase gene regulatory elements and expressed at high levels. A signal-encoding sequence may be inserted independent of, or along with, the heterologous DNA leading to authentic secretion of the heterologous protein.
    Type: Grant
    Filed: July 18, 1988
    Date of Patent: December 15, 1992
    Assignee: Biotechnica International, Inc.
    Inventors: Alan Sloma, Nancy M. Hannett, M. A. Stephens, Cathy F. Rudolph, Gerald A. Rufo, Jr., Janice Pero