Patents by Inventor Gerald A. Tuskan

Gerald A. Tuskan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10907164
    Abstract: Disclosed herein are vectors and components for a nucleic acid cloning system, and methods of use of the vectors and components in cloning nucleic acid fragments of interest. The cloning system includes two families of destination vectors which can be used in alternating form to systematically combine nucleic acid fragments of interest.
    Type: Grant
    Filed: June 11, 2018
    Date of Patent: February 2, 2021
    Assignee: UT-Battelle, LLC
    Inventors: Gerald A. Tuskan, Xiaohan Yang, Henrique Cestari De Paoli
  • Patent number: 10900094
    Abstract: Pathogenic fungi from the genus Sphaerulina cause damage to a diverse array of economically important plant species. The present disclosure provides methods of determining whether a plant is susceptible to pathogenic fungi infections. The disclosure further provides methods of engineering pathogenic fungi-resistant plants from susceptible plants using targeted genome editing techniques.
    Type: Grant
    Filed: October 1, 2018
    Date of Patent: January 26, 2021
    Assignee: UT-BATTELLE, LLC
    Inventors: Wellington Muchero, Jay Chen, Gerald A. Tuskan, Jared Leboldus
  • Publication number: 20200399637
    Abstract: The present disclosure provides genetically modified plants, plant cells and plant tissues that show reduced lignin content as compared to a control plant which was not genetically modified. In addition, the disclosure provides methods of regulating lignin content in a plant. The disclosure also provides methods of producing bioproducts using the genetically modified plants of the instant disclosure.
    Type: Application
    Filed: June 19, 2019
    Publication date: December 24, 2020
    Inventors: Meng Xie, Jin-Gui Chen, Lee E. Gunter, Sara S. Jawdy, Wellington Muchero, Gerald Tuskan, Jin Zhang
  • Publication number: 20200377903
    Abstract: This disclosure provides genetically modified plants, plant cells and plant tissues that show modified lignin content and/or sugar release as compared to a wild type control plant which was not genetically modified. In addition, the disclosure provides methods of regulating lignin content and sugar release in a plant. The disclosure also provides methods of producing bioproducts using the genetically modified plants of the instant disclosure.
    Type: Application
    Filed: June 2, 2020
    Publication date: December 3, 2020
    Inventors: Meng Xie, Wellington Muchero, Jin-Gui Chen, Gerald A. Tuskan, Patricia Larisse Taboada-Serrano
  • Publication number: 20200239901
    Abstract: The present disclosure provides methods for increasing drought resistance, salt resistance, photosynthetic rate, biomass production and water-use efficiency of a plant. The methods encompass expression of CAM-specific a phosphoenolpyruvate carboxylase (PEPC) in the plant. In comparison to a plant not manipulated in this manner, the disclosed, genetically-modified, plants display improved drought resistance and salt resistance. Also provided are plants that can be obtained by the method according to the invention, and nucleic acid vectors to be used in the described methods.
    Type: Application
    Filed: January 28, 2020
    Publication date: July 30, 2020
    Inventors: Xiaohan Yang, Degao Liu, Rongbin Hu, Gerald A. Tuskan
  • Publication number: 20200032285
    Abstract: The present disclosure is directed to methods of improving mycorrhization in a plant or plant cell. Another aspect of this disclosure is directed to a genetically modified plant or plant cell with improved mycorrhization.
    Type: Application
    Filed: July 24, 2019
    Publication date: January 30, 2020
    Inventors: Wellington Muchero, Jessy L. Labbe, Lee E. Gunter, Jin-Gui Chen, Sara S. Jawdy, Xiaohan Yang, Gerald A. Tuskan, Juan Wang, Olaf Czarnecki, Priya Ranjan
  • Publication number: 20200032282
    Abstract: This disclosure provides methods of improving callus formation in plants. This disclosure further provides genetically engineered plants with improved callus formation.
    Type: Application
    Filed: July 30, 2019
    Publication date: January 30, 2020
    Inventors: Wellington Muchero, Gerald Tuskan, Jin-Gui Chen, Lee E. Gunter
  • Publication number: 20190390212
    Abstract: The invention relates to expression of the PdHB3 gene and uses thereof. The invention provides genetically engineered plants expressing the PdHB3 gene and inhibitors of PdHB3. The invention further provides a method for biofuel production using plant genetically engineered for expressing the PdHB3 gene. The invention further provides a method for increasing glucose and/or xylose release in a plant or plant cell.
    Type: Application
    Filed: September 4, 2019
    Publication date: December 26, 2019
    Inventors: Gerald A. Tuskan, Udaya C. Kalluri, Raja S. Payyavula
  • Publication number: 20190194763
    Abstract: Pathogenic fungi from the genus Sphaerulina cause damage to a diverse array of economically important plant species. The present disclosure provides methods of determining whether a plant is susceptible to pathogenic fungi infections. The disclosure further provides methods of engineering pathogenic fungi-resistant plants from susceptible plants using targeted genome editing techniques.
    Type: Application
    Filed: October 1, 2018
    Publication date: June 27, 2019
    Inventors: Wellington MUCHERO, Jay CHEN, Gerald A. TUSKAN, Jared LEBOLDUS
  • Publication number: 20190136251
    Abstract: The invention relates to expression of the PdHB3 gene and uses thereof. The invention provides genetically engineered plants expressing the PdHB3 gene and inhibitors of PdHB3. The invention further provides a method for biofuel production using plant genetically engineered for expressing the PdHB3 gene. The invention further provides a method for increasing glucose and/or xylose release in a plant or plant cell.
    Type: Application
    Filed: August 3, 2017
    Publication date: May 9, 2019
    Inventors: Gerald A. Tuskan, Udaya C. Kalluri, Raja S. Payyavula
  • Publication number: 20190136256
    Abstract: Disclosed herein are methods of producing plants with preferred levels of vegetative growth periods, flowering times, and resistance to stress and pathogens; and uses of such plants. The inventors have identified that the ANGUSTIFOLIA(AtAN)/CtBP gene is a major determinant of the carbon allocation between the Shikimate Pathway and the Salicylic Acid (SA) and Jasmonic Acid(JA)/Ethylene pathway. Plants with modulated growth periods, flowering times, and resistance to stress/pathogen characteristics, based on modulation of the expression or activity of the ANGUSTIFOLIA (ATAN)/CTBP gene, have divergent uses including pulp and paper production, bioproduct production, and as pathogen-resistant crops.
    Type: Application
    Filed: November 7, 2018
    Publication date: May 9, 2019
    Inventors: Jay CHEN, Wellington MUCHERO, Gerald A. TUSKAN, Anthony Christian BRYAN
  • Patent number: 10246719
    Abstract: This disclosure provides genetically modified plants having desirable levels of sugar release and syringyl/guaiacyl (S/G) ratio; methods of genetically modifying plants to modulate sugar release and S/G ratio; and uses of such plants. The inventors have determined that genetic modification of a laccase gene (LAC2) from Populus, encoded by locus Potri.008G064000 resulted in transgenic Populus trees with changes in syringyl/guaiacyl ratios as well as altered sugar release phenotypes. Plants with altered sugar release, and S/G ratio, based on modulation of the expression or activity of the LAC2 gene, have divergent uses including pulp and paper production, and biofuel and bioproducts production.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: April 2, 2019
    Assignee: UT-BATTELLE, LLC
    Inventors: Jin-Gui Chen, Lee E. Gunter, Sara S. Jawdy, Xiaohan Yang, Gerald A. Tuskan, Anthony Christian Bryan
  • Patent number: 10227601
    Abstract: This disclosure provides genetically modified plants having desirable levels of sugar release, cellulose content and reduction of recalcitrance; methods of genetically modifying plants to modulate sugar release, cellulose and lignin contents; and uses of such plants. The inventors have determined that genetic modification of PdDUF266A from Populus, encoded by locus Potri.011G009500 resulted in transgenic Populus trees with changes in lignin and cellulose content as well as altered sugar release phenotypes. Plants with altered sugar release, cellulose and lignin content, based on modulation of the expression or activity of the PdDUF266A gene, have diverse uses including pulp and paper production, and biofuel and bioproducts production.
    Type: Grant
    Filed: August 28, 2017
    Date of Patent: March 12, 2019
    Assignee: UT-Battelle, LLC
    Inventors: Jin-Gui Chen, Sara Jawdy, Xiaohan Yang, Gerald A. Tuskan, Yongil Yang, Lee E. Gunter
  • Patent number: 10167523
    Abstract: The invention provides plants having improved biomass properties of increased biomass quantity and density, increased cellulose content and deceased lignin content and improved sugar release efficiency, methods of generating (genetically modifying) and/or selecting (natural variant collections) plants with such preferred attributes of cellulose, lignin and sugar release, and uses of such plants. The inventors have determined that the expression of the gene, Potri.001G375700 (belonging to IQD signaling protein family containing a canonical calmodulin-binding domain) and/or activity of Potri.001G375700, modulates cellulose, lignin synthesis, sugar release and growth in plants.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: January 1, 2019
    Assignee: UT-Battelle, LLC
    Inventors: Gerald A. Tuskan, Udaya C. Kalluri
  • Publication number: 20180371487
    Abstract: The present disclosure provides methods for increasing drought resistance and heat resistance of a plant. The methods encompass expression of at least one heat shock protein (HSP) from the group consisting of HSP40, HSP60 or HSP70 together with a phosphoenolpyruvate carboxylase (PEPC) comprising an aspartic acid (D) at a position that corresponds to the position 509 of SEQ ID NO: 4, in the plant. In comparison to a plant not manipulated in this manner, the disclosed, genetically-modified, plants display improved drought resistance and heat resistance. Also provided are plants that can be obtained by the method according to the invention, and nucleic acid vectors to be used in the described methods.
    Type: Application
    Filed: June 22, 2018
    Publication date: December 27, 2018
    Inventors: Xiaohan Yang, Gerald A. Tuskan, Degao Liu, Rongbin Hu, Jin-Gui Chen, Meng Xie
  • Publication number: 20180312850
    Abstract: Disclosed herein are vectors and components for a nucleic acid cloning system, and methods of use of the vectors and components in cloning nucleic acid fragments of interest. The cloning system includes two families of destination vectors which can be used in alternating form to systematically combine nucleic acid fragments of interest.
    Type: Application
    Filed: June 11, 2018
    Publication date: November 1, 2018
    Applicant: UT-Battelle, LLC
    Inventors: Gerald A. Tuskan, Xiaohan Yang, Henrique Cestari De Paoli
  • Patent number: 10106807
    Abstract: The invention provides plants having desirable levels of sugar release and/or lignin synthesis. The invention further provides methods of selecting plants with such desirable levels of sugar release and/or lignin synthesis; methods of genetically modifying plants to modulate lignin synthesis, sugar release, and modulating phenylalanine, tyrosine, tryptophan and flavonoid production; and uses of such plants.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: October 23, 2018
    Assignees: UT-BATTELLE, LLC, WEST VIRGINIA UNIVERSITY
    Inventors: Wellington Muchero, Jay Chen, Lee E. Gunter, Sara Jawdy, Gerald A. Tuskan, Anthony Christian Bryan, Stephen Difazio, Hao-Bo Guo
  • Patent number: 10017770
    Abstract: Disclosed herein are vectors and components for a nucleic acid cloning system, and methods of use of the vectors and components in cloning nucleic acid fragments of interest. The cloning system includes two families of destination vectors which can be used in alternating form to systematically combine nucleic acid fragments of interest.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: July 10, 2018
    Assignee: UT-BATTELLE, LLC
    Inventors: Gerald A. Tuskan, Xiaohan Yang, Henrique Cestari De Paoli
  • Patent number: 9994998
    Abstract: This disclosure provides plants having desirable levels of lignin synthesis, sugar release, S/G ratio, and resistance to stress and pathogens; methods of selecting plants with such desirable levels of lignin synthesis, sugar release, S/G ratio, and resistance to stress and pathogens; methods of genetically modifying plants to modulate lignin synthesis, sugar release, S/G ratio, and resistance to stress and pathogens; and uses of such plants. The inventors have determined that the expression and/or activity of POPTR_0014s08530, a gene encoding an Angustifolia/CtBP transcription factor, modulates lignin synthesis, sugar release, S/G ratio, and resistance to stress and pathogens in plants. Plants with lignin synthesis, sugar release, S/G ratio, and resistance to stress and pathogens, based on modulation of the expression or activity of the POPTR_0014s08530 gene, have divergent uses including pulp and paper production, and ethanol/biofuel production.
    Type: Grant
    Filed: March 4, 2015
    Date of Patent: June 12, 2018
    Assignee: UT-BATTELLE, LLC
    Inventors: Jay Chen, Lee E. Gunter, Sara Jawdy, Wellington Muchero, Gerald Tuskan, Jianjun Guo, Priya Ranjan, Stephen P. DiFazio, Anthony C. Bryan
  • Publication number: 20180057834
    Abstract: This disclosure provides genetically modified plants having desirable levels of sugar release, cellulose content and reduction of recalcitrance; methods of genetically modifying plants to modulate sugar release, cellulose and lignin contents; and uses of such plants. The inventors have determined that genetic modification of PdDUF266A from Populus, encoded by locus Potri.011G009500 resulted in transgenic Populus trees with changes in lignin and cellulose content as well as altered sugar release phenotypes. Plants with altered sugar release, cellulose and lignin content, based on modulation of the expression or activity of the PdDUF266A gene, have diverse uses including pulp and paper production, and biofuel and bioproducts production.
    Type: Application
    Filed: August 28, 2017
    Publication date: March 1, 2018
    Inventors: Jin-Gui Chen, Sara Jawdy, Xiaohan Yang, Gerald A. Tuskan, Yongil Yang, Lee E. Gunter