Patents by Inventor Gerald B. Tometzki

Gerald B. Tometzki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of drug design
    Patent number: 9709571
    Abstract: The invention provides a method of identifying biologically active compounds comprising: (a) designing a first library of compounds of formula (1) to scan molecular diversity wherein each compound of the library has at least two pharmacophoric groups R1 to R5 as defined below and wherein compound of the library has same number of pharmacophoric groups; (b) assaying the first library of compounds in one or more biological assay(s); and (c) designing a second library wherein each compound of the second library contains one or more additional pharmacophoric group with respect to the first library; such that the/each component of the first and second library is a compound of formula (1).
    Type: Grant
    Filed: February 20, 2013
    Date of Patent: July 18, 2017
    Assignee: VAST BIOSCIENCE PTY LIMITED
    Inventors: Gerald B. Tometzki, Wim F. Meutermans, Johannes Zuegg
  • 4-aminopyrrolopyrimidines as kinase inhibitors
    Patent number: 7863444
    Abstract: Chemical compounds having structural formula I and physiologically acceptable salts thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the kinases whose activity is inhibited by these compounds are involved in immunologic, hyperproliferative or angiogenic processes. Thus, these compounds can ameliorate disase states where angiogenesis or endothelial cell hyperproliferaton is a factor. These compounds can be used to treat cancer, hyperproliferative disorders, rheumatoid artheritis, disorders of the immune system, transplant rejection, and inflammatory disorders.
    Type: Grant
    Filed: September 17, 1999
    Date of Patent: January 4, 2011
    Assignee: Abbott Laboratories
    Inventors: David Calderwood, Lee Arnold, Hormoz Mazdiyasni, Gavin C. Hirst, Bojuan B. Deng, David N. Johnston, Paul Rafferty, Gerald B. Tometzki, Helen L. Twigger, Rainer Munschauer
  • Method of Drug Design
    Publication number: 20090163373
    Abstract: The invention provides a method of identifying biologically active compounds comprising: (a) designing a first library of compounds of formula (1) to scan molecular diversity wherein each compound of the library has at least two pharmacophoric groups R1 to R5 as defined below and wherein compound of the library has same number of pharmacophoric groups; (b) assaying the first library of compounds in one or more biological assay(s); and (c) designing a second library wherein each compound of the second library contains one or more additional pharmacophoric group with respect to the first library; such that the/each component of the first and second library is a compound of formula (1).
    Type: Application
    Filed: October 3, 2006
    Publication date: June 25, 2009
    Applicant: Alchemia Limited
    Inventors: Gerald B. Tometzki, Michael L. West, Wim Meutermans, Johannes Zuegg
  • 4-AMINOPYRROLOPYRIMIDINES AS KINASE INHIBITORS
    Publication number: 20030187001
    Abstract: Chemical compounds having structural formula I 1
    Type: Application
    Filed: September 17, 1999
    Publication date: October 2, 2003
    Inventors: DAVID CALDERWOOD, LEE ARNOLD, HORMOZ MAZDIYASNI, GAVIN C. HIRST, BOJUAN B. DENG, DAVID N. JOHNSTON, PAUL RAFFERTY, GERALD B. TOMETZKI, HELEN L. TWIGGER, RAINER MUNSCHAUER