Patents by Inventor Gerald Bradley

Gerald Bradley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of anxiety and gastrointestinal disorders with azabicyclo carbonyl-2-(cyclopropylmethyloxy)benzamide
    Patent number: 5436251
    Abstract: (Endo)-N-[[[8-azabicyclo[3.2.1]octan-3-yl]amino]carbonyl]-2-(cyclopropylmet hyloxy)benzamide and pharmaceutically acceptable salts thereof possess 5-HT.sub.3 antagonistic activity and are useful in the treatment of neuro-psychiatric disorders (e.g. anxiety), gastro-intestinal disorders and migraine.
    Type: Grant
    Filed: August 13, 1993
    Date of Patent: July 25, 1995
    Assignee: John Wyeth & Brother, Limited
    Inventors: Terence J. Ward, Gerald Bradley
  • Heterocyclic compounds useful as 5-HT.sub.3 antagonists
    Patent number: 4983600
    Abstract: Aroyl ureas and carbamic acid derivatives of formulaA--CO--NHCW--Y--Band pharmaceutically acceptable salts thereof whereinA is a specified aromatic radical including optionally substituted phenylW is O or SY is NH or S andB is a specified saturated azacyclic ring, eg tropan-3-yl or quinuclidin-3-yl,possess 5-HT.sub.3 -antagonistic activity and are, for example, useful in treatment of migraine, emesis, anxiety, gastro-intestinal disorders and as anti-psychotics.
    Type: Grant
    Filed: October 16, 1989
    Date of Patent: January 8, 1991
    Assignee: John Wyeth & Brother Limited
    Inventors: Terence J. Ward, Janet C. White, Gerald Bradley
  • Stable crystal form of 1,4-dihydro-2-(imidazolyl-1-ylmethyl)-6-methyl-4-(3-nitrophenyl)pyridine -3,5-dicarboxylic acid 3-ethyl 5-methyl diester, hydrochloride
    Patent number: 4983617
    Abstract: The invention concerns a new stable crystal form of anhydrous, crystalline 1,4-dihydro-2-(imidazol-1-ylmethyl)-6-methyl-4-(3-nitrophenyl)pyridine)-3, 5-dicarboxylic acid 3-ethyl 5-methyl diester hydrochloride, "having a melting point greater than about 215.degree. C., an infra red spectrum (nujolmull) having sharp peaks at 3195 cm.sup.-1, 3100 cm.sup.-1, 2735 cm.sup.-1 and 2625 cm.sup.-1 and an x-ray powder diffraction pattern with specific peaks occurring at 2.theta.=12.3.degree. and 44.5.degree..
    Type: Grant
    Filed: December 12, 1988
    Date of Patent: January 8, 1991
    Assignee: John Wyeth and Brothers Limited
    Inventors: Gerald Bradley, Geoffrey P. R. Carr, Albert Opalko, Richard J. Yarwood
  • Analgesic method
    Patent number: 4409218
    Abstract: Morpholine derivatives of the formula ##STR1## and their acid addition salts, wherein n represents 1, 2 or 3, R.sup.3 is alkyl of 1 to 10 carbon atoms, R.sup.4 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl(lower)alkyl, 2-tetrahydrofurylmethyl or cyclo (lower)alkylmethyl and OR.sup.5 is hydroxy, acyloxy or a protected hydroxy group possess analgesic and/or opiate antagonistic activity or are useful as intermediates for other compounds of formula I possessing such activity.
    Type: Grant
    Filed: March 11, 1982
    Date of Patent: October 11, 1983
    Assignee: John Wyeth and Brother Limited
    Inventors: Alan C. White, Gerald Bradley
  • Morpholines
    Patent number: 4387097
    Abstract: Morpholine derivatives of the formula ##STR1## and their acid addition salts, wherein n represents 1, 2 or 3, R.sup.4 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl(lower)alkyl, 2-tetrahydrofurylmethyl or cyclo(lower)alkylmethyl, R.sup.2 and R.sup.3 are each hydrogen or alkyl of 1 to 10 carbon atoms and OR.sup.5 is hydroxy, acyloxy or a protected hydroxy group possess analgesic and/or opiate antagonistic activity or are useful as intermediates for other compounds of formula I possessing such activity.
    Type: Grant
    Filed: March 11, 1982
    Date of Patent: June 7, 1983
    Assignee: John Wyeth and Brother Limited
    Inventors: Alan C. White, Gerald Bradley