Patents by Inventor Gerald C. Smaldone
Gerald C. Smaldone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11452823Abstract: A breath-enhanced jet nebulizer is configured with a low liquid retention reservoir and a narrow liquid delivery passage to efficiently and efficiently aerosolize small drug volumes with minimal waste. Aerosol particles are directed through aerosol passage for delivery, although larger liquid particles are directed away from the aerosol outlet and recycled to the liquid reservoir.Type: GrantFiled: September 1, 2017Date of Patent: September 27, 2022Assignees: INSPIRX, INC., THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORKInventors: Rohinton D. Toddywala, Vijay Shukla, Gerald C. Smaldone
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Publication number: 20190192790Abstract: A breath-enhanced jet nebulizer is configured with a low liquid retention reservoir and a narrow liquid delivery passage to efficiently and efficiently aerosolize small drug volumes with minimal waste. Aerosol particles are directed through aerosol passage for delivery, although larger liquid particles are directed away from the aerosol outlet and recycled to the liquid reservoir.Type: ApplicationFiled: September 1, 2017Publication date: June 27, 2019Applicants: INSPIRX, INC., THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY O F NEW YORKInventors: Rohinton D. TODDYWALA, Vijay SHUKLA, Gerald C. SMALDONE
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Patent number: 10004858Abstract: The present invention provides an improved means of treating tracheobronchitis, bronchiectasis and pneumonia in the nosocomial patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one aspect, the invention assures this result when aerosol is delivered into the ventilator circuit. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In another aspect, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The treatment means eliminates the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit.Type: GrantFiled: July 1, 2013Date of Patent: June 26, 2018Assignee: The Research Foundation for the State University of New YorkInventors: Gerald C. Smaldone, Lucy B. Palmer
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Publication number: 20140053830Abstract: The present invention provides an improved means of treating tracheobronchitis, bronchiectasis and pneumonia in the nosocomial patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one aspect, the invention assures this result when aerosol is delivered into the ventilator circuit. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In another aspect, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The treatment means eliminates the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit.Type: ApplicationFiled: August 15, 2013Publication date: February 27, 2014Applicant: The Research Foundation of State University of New YorkInventors: Gerald C. Smaldone, Lucy B. Palmer
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Publication number: 20140014103Abstract: The present invention provides a method and novel devices for treating tracheobronchitis and pneumonia in the intubated patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In a preferred embodiment, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The devices eliminate the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit. The treatment also concentrates the therapeutic agent specifically at affected sites in the lung such that therapeutic levels of administrated drug are achieved without significant systemic exposure of the patient to the drug.Type: ApplicationFiled: July 12, 2012Publication date: January 16, 2014Inventors: Gerald C. Smaldone, Lucy B. Palmer
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Patent number: 8602023Abstract: The invention provides improved devices for treating tracheobronchitis, bronchiectasis and pneumonia in intubated patients, with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim. In one aspect, the invention assures this result when aerosol is delivered into the ventilator circuit. In one embodiment, the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In another aspect, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The devices eliminate the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit. The treatment also concentrates the therapeutic agent at affected sites in the lung such that therapeutic levels of administrated drug are achieved without systemic exposure of the patient to the drug. The invention further provides a dose control device to govern this regimen.Type: GrantFiled: February 22, 2005Date of Patent: December 10, 2013Assignee: The Research Foundation for the State University of New YorkInventors: Gerald C. Smaldone, Lucy B. Palmer
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Publication number: 20130298904Abstract: The present invention provides an improved means of treating tracheobronchitis, bronchiectasis and pneumonia in the nosocomial patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one aspect, the invention assures this result when aerosol is delivered into the ventilator circuit. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In another aspect, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The treatment means eliminates the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit.Type: ApplicationFiled: July 1, 2013Publication date: November 14, 2013Applicant: The Research Foundation of State University of New YorkInventors: Gerald C. Smaldone, Lucy B. Palmer
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Patent number: 8261747Abstract: The present invention provides an improved means of treating tracheobronchitis, bronchiectasis and pneumonia in the nosocomial patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one aspect, the invention assures this result when aerosol is delivered into the ventilator circuit. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In another aspect, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The treatment means eliminates the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit.Type: GrantFiled: April 25, 2005Date of Patent: September 11, 2012Assignee: The Research Foundation of State University of New YorkInventors: Gerald C. Smaldone, Lucy B. Palmer
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Patent number: 8245708Abstract: The present invention provides an improved method and novel devices for treating tracheobronchitis, bronchiectasis and pneumonia in the intubated patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one aspect, the invention assures this result when aerosol is delivered into the ventilator circuit. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In another aspect, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The devices eliminate the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit.Type: GrantFiled: May 6, 2003Date of Patent: August 21, 2012Assignee: The Research Foundation of State University of New YorkInventors: Gerald C. Smaldone, Lucy B. Palmer
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Publication number: 20120148532Abstract: A method of treating a pulmonary disease such as, for instance idiophathic pulmonary fibrosis (IPF) and asthma, comprising administering an aerosolized interferon such as interferon ?, interferon ? or interferon ? in a therapeutically effective amount is provided herein. Also, pharmaceutical compositions of one or more aerosolized interferon(s) are provided.Type: ApplicationFiled: February 3, 2009Publication date: June 14, 2012Inventors: Rany Condos, Gerald C. Smaldone
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Publication number: 20110059044Abstract: A method of treating a pulmonary disease such as, for instance idiophathic pulmonary fibrosis (IPF) and asthma, comprising administering an aerosolized interferon such as interferon ?, interferon ? or interferon ? in a therapeutically effective amount is provided herein. Also, pharmaceutical compositions of one or more aerosolized interferon(s) are provided.Type: ApplicationFiled: January 6, 2010Publication date: March 10, 2011Inventors: Rany Condos, Gerald C. Smaldone
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Publication number: 20100041766Abstract: The present invention provides an improved means of treating tracheobronchitis, bronchiectasis and pneumonia in the nosocomial patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one aspect, the invention assures this result when aerosol is delivered into the ventilator circuit. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In another aspect, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The treatment means eliminates the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit.Type: ApplicationFiled: August 24, 2009Publication date: February 18, 2010Inventors: Gerald C. Smaldone, Lucy B. Palmer
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Patent number: 7607436Abstract: The present invention provides an improved means of treating tracheobronchitis, bronchiectasis and pneumonia in the nosocomial patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one aspect, the invention assures this result when aerosol is delivered into the ventilator circuit. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In another aspect, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The treatment means eliminates the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit.Type: GrantFiled: November 30, 2004Date of Patent: October 27, 2009Assignee: The Research Foundation of State University of New YorkInventors: Gerald C. Smaldone, Lucy B. Palmer
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Patent number: 7334580Abstract: The present invention provides an improved method and novel devices for treating tracheobronchitis, bronchiectasis and pneumonia in the intubated patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one aspect, the invention assures this result when aerosol is delivered into the ventilator circuit. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In another aspect, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The devices eliminate the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit.Type: GrantFiled: May 6, 2003Date of Patent: February 26, 2008Inventors: Gerald C. Smaldone, Lucy B. Palmer
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Patent number: 7082947Abstract: Face masks for use in pressurized drug delivery applications, such as aerosol drug delivery systems, and a method of reducing aerosol deposition in the region of the eyes are presented. The face masks according to the various embodiments disclosed herein contain features that reduce the inertia of the aerosolized drug in perinasal areas. This results in a reduction in the amount of aerosolized drug that is deposited in the region of the eyes by inertial impaction, while at the same time, the features are constructed to maintain the flow of the aerosolized drug into the face mask so that the aerosolized drug is effectively delivered to the respiratory system of the patient.Type: GrantFiled: October 28, 2004Date of Patent: August 1, 2006Inventor: Gerald C. Smaldone
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Patent number: 6748949Abstract: Face masks for use in pressurized drug delivery applications, such as aerosol drug delivery systems, and a method of reducing aerosol deposition in the region of the eyes are presented. The face masks according to the various embodiments disclosed herein contain features that reduce the inertia of the aerosolized drug in perinasal areas. This results in a reduction in the amount of aerosolized drug that is deposited in the region of the eyes by inertial impaction, while at the same time, the features are constructed to maintain the flow of the aerosolized drug into the face mask so that the aerosolized drug is effectively delivered to the respiratory system of the patient.Type: GrantFiled: May 17, 2002Date of Patent: June 15, 2004Inventor: Gerald C. Smaldone
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Publication number: 20040035413Abstract: The present invention provides an improved means of treating tracheobronchitis, bronchiectasis and pneumonia in the nosocomial patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one aspect, the invention assures this result when aerosol is delivered into the ventilator circuit. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In another aspect, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The treatment means eliminates the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit.Type: ApplicationFiled: May 6, 2003Publication date: February 26, 2004Applicants: The Research Foundation, The State Univertsity of New YorkInventors: Gerald C. Smaldone, Lucy B. Palmer
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Publication number: 20040011358Abstract: The present invention provides an improved means of treating tracheobronchitis, bronchiectasis and pneumonia in the nosocomial patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one aspect, the invention assures this result when aerosol is delivered into the ventilator circuit. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In another aspect, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The treatment means eliminates the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit.Type: ApplicationFiled: May 6, 2003Publication date: January 22, 2004Applicant: The State University of New York at Stony BrookInventors: Gerald C. Smaldone, Lucy B. Palmer
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Publication number: 20020195107Abstract: Face masks for use in pressurized drug delivery applications, such as aerosol drug delivery systems, and a method of reducing aerosol deposition in the region of the eyes are presented. The face masks according to the various embodiments disclosed herein contain features that reduce the inertia of the aerosolized drug in perinasal areas. This results in a reduction in the amount of aerosolized drug that is deposited in the region of the eyes by inertial impaction, while at the same time, the features are constructed to maintain the flow of the aerosolized drug into the face mask so that the aerosolized drug is effectively delivered to the respiratory system of the patient.Type: ApplicationFiled: May 17, 2002Publication date: December 26, 2002Inventor: Gerald C. Smaldone