Abstract: A PEPCK inhibitor can include identifying a molecule that has a size capable of fitting into and interacting with the PEPCK binding site and at least one of the following: (a) a first terminal substituent having co-planar atoms acting as metal ligands to the active site metal ion PEPCK; (b) at least one of an atom or substituent at positions 2 or 3 from the first terminal substituent includes a neutral carbon center or include an oxygen, sulfur, selenium, or other atom with similar physiochemical properties; (c) at least one of an atom or substituent at positions 2 or 3 from the first terminal substituent is devoid of an electropositive atom or substituents; or (d) a second terminal substituent opposite of the first terminal substituent, said second terminal substituent having an atom that is a hydrogen boding acceptor and/or is negatively charged.

Abstract: A PEPCK inhibitor can include identifying a molecule that has a size capable of fitting into and interacting with the PEPCK binding site and at least one of the following: (a) a first terminal substituent having co-planar atoms acting as metal ligands to the active site metal ion PEPCK; (b) at least one of an atom or substituent at positions 2 or 3 from the first terminal substituent includes a neutral carbon center or include an oxygen, sulfur, selenium, or other atom with similar physiochemical properties; (c) at least one of an atom or substituent at positions 2 or 3 from the first terminal substituent is devoid of an electropositive atom or substituents; or (d) a second terminal substituent opposite of the first terminal substituent, said second terminal substituent having an atom that is a hydrogen boding acceptor and/or is negatively charged.

Abstract: A variable camber sanding board includes a generally planar and flexible sanding base, which is adapted to receive abrasive sheet material. A front frame is pivotably linked to a mid handle via a front pivot connection. The front pivot connection includes a pin passing through coaxial bores formed in the mid handle and front frame. A mid handle includes a slotted attachment member which is pivotably secured to a trigger link, forming a middle pivot connection. The trigger link is pivotably secured to a rear handle which is secured to the sanding base via a rear frame. An adjustment pivot connection includes a pin passing through coaxial bores formed in the slot link and rear frame, respectively. A threaded knob assembly, which passes through a bore located in the trigger link and a slot in the slot link can be selectively tightened in a desired position along the length of the slot link.

Abstract: An apparatus for supporting an abrasive material includes a flexible base defined by a first end and a second end, and by a lower surface which supports the abrasive material and an upper surface opposite the lower surface. The flexible base is fabricated from a resilient material so as to assume an essentially flat shape when the ends of the flexible base are not acted on by external forces. A front frame is member attached to the flexible base proximate the first end, and a rear frame member is attached to the flexible base proximate the second end. An adjustable connecting link has a first end connected to the front frame member in fixed relation thereto. A second end of the adjustable connecting link is connected to the rear frame member by a variably positionable connection.

Abstract: An apparatus for supporting an abrasive material includes a flexible base defined by a first end and a second end, and by a lower surface which supports the abrasive material and an upper surface opposite the lower surface. The flexible base is fabricated from a resilient material so as to assume an essentially flat shape when the ends of the flexible base are not acted on by external forces. A front frame is member attached to the flexible base proximate the first end, and a rear frame member is attached to the flexible base proximate the second end. An adjustable connecting link has a first end connected to the front frame member in fixed relation thereto. A second end of the adjustable connecting link is connected to the rear frame member by a variably positionable connection.