Patents by Inventor Gerald D. Artman, III

Gerald D. Artman, III has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SOLID FORMS COMPRISING (S)-4-(4-(4-(((2-(2,6-DIOXOPIPERIDIN-3-YL)-1-OXOISOINDOLIN-4-YL)OXY)METHYL)BENZYL)PIPERAZIN-1-YL)-3-FLUOROBENZONITRILE AND SALTS THEREOF, AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME
    Publication number: 20220289713
    Abstract: Provided herein are formulations, processes, solid forms and methods of use relating to salts of and solid forms comprising free base or salts of (S)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile.
    Type: Application
    Filed: May 27, 2022
    Publication date: September 15, 2022
    Inventors: Gerald D. Artman, III, Antonio C. Ferretti, Lianfeng Huang, Udaykumar Jain, Hon-Wah Man, Paula A. Tavares-Greco, Wenju Wu, Nancy Nienhua Tsou, Zhiwei Yin
  • ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20220280505
    Abstract: Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.
    Type: Application
    Filed: November 8, 2021
    Publication date: September 8, 2022
    Inventors: Matthew D. Alexander, Gerald D. Artman, III, Gordon L. Bray, James Carmichael, Soraya Carrancio, Brian E. Cathers, Matthew D. Correa, Joshua Hansen, Courtney G. Havens, Timothy S. Kercher, Antonia Lopez-Girona, Xiaoling Lu, Hon-Wah Man, Mark A. Nagy, Rama K. Narla, Joseph R. Piccotti, Daniel W. Pierce, Paula A. Tavares-Greco, Brandon W. Whitefield, Lilly L. Wong, Nanfei Zou
  • Solid forms comprising (s)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile and salts thereof, and compositions comprising and methods of using the same
    Patent number: 11370777
    Abstract: Provided herein are formulations, processes, solid forms and methods of use relating to salts of and solid forms comprising free base or salts of (S)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile.
    Type: Grant
    Filed: January 8, 2020
    Date of Patent: June 28, 2022
    Assignee: Celgene Corporation
    Inventors: Gerald D. Artman, III, Antonio C. Ferretti, Lianfeng Huang, Udaykumar Jain, Hon-Wah Man, Paula A. Tavares-Greco, Wenju Wu, Nancy Nienhua Tsou, Zhiwei Yin
  • Antiproliferative compounds and methods of use thereof
    Patent number: 11185543
    Abstract: Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.
    Type: Grant
    Filed: April 27, 2020
    Date of Patent: November 30, 2021
    Assignee: Celgene Corporation
    Inventors: Matthew D. Alexander, Gerald D. Artman, III, James Carmichael, Brian E. Cathers, Matthew D. Correa, Joshua Hansen, Courtney G. Havens, Timothy S. Kercher, Antonia Lopez-Girona, Xiaoling Lu, Hon-Wah Man, Mark A. Nagy, Joseph R. Piccotti, Daniel W. Pierce, Paula A. Tavares-Greco, Brandon W. Whitefield, Lilly L. Wong, Nanfei Zou
  • ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20200253964
    Abstract: Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.
    Type: Application
    Filed: April 27, 2020
    Publication date: August 13, 2020
    Inventors: Matthew D. Alexander, Gerald D. Artman, III, Gordon L. Bray, James Carmichael, Soraya Carrancio, Brian E. Cathers, Matthew D. Correa, Joshua Hansen, Courtney G. Havens, Timothy S. Kercher, Antonia Lopez-Girona, Xiaoling Lu, Hon-Wah Man, Mark A. Nagy, Rama K. Narla, Joseph R. Piccotti, Daniel W. Pierce, Paula A. Tavares-Greco, Brandon W. Whitefield, Lilly L. Wong, Nanfei Zou
  • SOLID FORMS COMPRISING (S)-4-(4-(4-(((2-(2,6-DIOXOPIPERIDIN-3-YL)-1-OXOISOINDOLIN-4-YL)OXY)METHYL)BENZYL)PIPERAZIN-1-YL)-3-FLUOROBENZONITRILE AND SALTS THEREOF, AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME
    Publication number: 20200216418
    Abstract: Provided herein are formulations, processes, solid forms and methods of use relating to salts of and solid forms comprising free base or salts of (S)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile.
    Type: Application
    Filed: January 8, 2020
    Publication date: July 9, 2020
    Inventors: Gerald D. Artman, III, Antonio C. Ferretti, Lianfeng Huang, Udaykumar Jain, Hon-Wah Man, Paul A. Tavares-Greco, Wenju Wu
  • Antiproliferative compounds and methods of use thereof
    Patent number: 10675281
    Abstract: Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.
    Type: Grant
    Filed: June 3, 2019
    Date of Patent: June 9, 2020
    Assignee: Celgene Corporation
    Inventors: Matthew D. Alexander, Gerald D. Artman, III, Matthew D. Correa, Joshua Hansen, Xiaoling Lu, Hon-Wah Man, Mark A. Nagy, Paula A. Tavares-Greco, Brandon W. Whitefield, Nanfei Zou
  • ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20190282567
    Abstract: Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.
    Type: Application
    Filed: June 3, 2019
    Publication date: September 19, 2019
    Inventors: Matthew D. Alexander, Gerald D. Artman, III, Gordon L. Bray, James Carmichael, Soraya Carrancio, Brian E. Cathers, Matthew D. Correa, Joshua Hansen, Courtney G. Havens, Timothy S. Kercher, Antonia Lopez-Girona, Xiaoling Lu, Hon-Wah Man, Mark A. Nagy, Rama K. Narla, Joseph R. Piccotti, Daniel W. Pierce, Paula A. Tavares-Greco, Brandon W. Whitefield, Lilly L. Wong, Nanfei Zou
  • Antiproliferative compounds and methods of use thereof
    Patent number: 10357489
    Abstract: Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: July 23, 2019
    Assignee: Celgene Corporation
    Inventors: Matthew D. Alexander, Gerald D. Artman, III, James Carmichael, Brian E. Cathers, Matthew D. Correa, Joshua Hansen, Courtney G. Havens, Timothy S. Kercher, Antonia Lopez-Girona, Xiaoling Lu, Hon-Wah Man, Mark A. Nagy, Joseph R. Piccotti, Daniel W. Pierce, Paula A. Tavares-Greco, Brandon W. Whitefield, Lilly L. Wong, Nanfei Zou
  • ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20190008852
    Abstract: Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.
    Type: Application
    Filed: July 9, 2018
    Publication date: January 10, 2019
    Inventors: Matthew D. Alexander, Gerald D. Artman, III, Gordon L. Bray, James Carmichael, Soraya Carrancio, Brian E. Cathers, Matthew D. Correa, Joshua Hansen, Courtney G. Havens, Timothy S. Kercher, Antonia Lopez-Girona, Xiaoling Lu, Hon-Wah Man, Mark A. Nagy, Rama K. Narla, Joseph R. Piccotti, Daniel W. Pierce, Paula A. Tavares-Greco, Brandon W. Whitefield, Lilly L. Wong, Nanfei Zou
  • PPAR-sparing compounds for the treatment of metabolic diseases
    Patent number: 9562012
    Abstract: The present invention relates to hydroxamate compounds and pharmaceutical compositions that are useful for treating and/or preventing metabolic inflammation mediated diseases such as diabetes, obesity, hypertension, dyslipidemia, a neurodegenerative disorder (e.g., Alzheimer's disease, Parkinson's disease, or Huntington's disease), or any combination thereof. Moreover, the present invention also provides methods of treatment for these diseases or disorders.
    Type: Grant
    Filed: July 21, 2014
    Date of Patent: February 7, 2017
    Assignee: Metabolic Solutions Development Company, LLC
    Inventors: Steven P. Tanis, Scott D. Larsen, Gerald D. Artman, III, Timothy Parker
  • PPAR-SPARING COMPOUNDS FOR THE TREATMENT OF METABOLIC DISEASES
    Publication number: 20160152570
    Abstract: The present invention relates to hydroxamate compounds and pharmaceutical compositions that are useful for treating and/or preventing metabolic inflammation mediated diseases such as diabetes, obesity, hypertension, dyslipidemia, a neurodegenerative disorder (e.g., Alzheimer's disease, Parkinson's disease, or Huntington's disease), or any combination thereof. Moreover, the present invention also provides methods of treatment for these diseases or disorders.
    Type: Application
    Filed: July 21, 2014
    Publication date: June 2, 2016
    Inventors: Steven P. Tanis, Scott D. Larsen, Gerald D. Artman, III, Timothy Parker
  • Synthesis for thiazolidinedione compounds
    Patent number: 8946435
    Abstract: The present invention provides novel methods for synthesizing PPAR? sparing compounds, e.g., thiazolidinediones, that are useful for preventing and/or treating metabolic disorders such as diabetes, obesity, hypertension, and inflammatory diseases.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: February 3, 2015
    Assignee: Metabolic Solutions Development Company, LLC
    Inventors: Steven P. Tanis, Timothy Parker, Robert C. Gadwood, James R. Zeller, Gerald D. Artman, III, Scott D. Larsen
  • Synthesis for thiazolidinedione compounds
    Patent number: 8933240
    Abstract: The present invention provides novel methods for synthesizing PPAR? sparing compounds, e.g., thiazolidinediones, that are useful for preventing and/or treating metabolic disorders such as diabetes, obesity, hypertension, and inflammatory diseases.
    Type: Grant
    Filed: August 9, 2011
    Date of Patent: January 13, 2015
    Assignee: Metabolic Solutions Development Company, LLC
    Inventors: Steven P. Tanis, Timothy Parker, Robert C. Gadwood, Gerald D. Artman, III, James R. Zeller
  • Synthesis for Thiazolidinedione Compounds
    Publication number: 20140378687
    Abstract: The present invention provides novel methods for synthesizing PPAR? sparing compounds, e.g., thiazolidinediones, that are useful for preventing and/or treating metabolic disorders such as diabetes, obesity, hypertension, and inflammatory diseases.
    Type: Application
    Filed: September 5, 2014
    Publication date: December 25, 2014
    Inventors: Steven P. Tanis, Timothy Parker, Robert C. Gadwood, James R. Zeller, Gerald D. Artman, III, Scott D. Larsen
  • Synthesis for thiazolidinedione compounds
    Patent number: 8895748
    Abstract: The present invention provides novel methods for synthesizing PPAR? sparing compounds, e.g., thiazolidinediones, that are useful for preventing and/or treating metabolic disorders such as diabetes, obesity, hypertension, and inflammatory diseases.
    Type: Grant
    Filed: August 9, 2011
    Date of Patent: November 25, 2014
    Assignee: Metabolic Solutions Development Company, LLC
    Inventors: Steven P. Tanis, Timothy Parker, Robert C. Gadwood, James R. Zeller, Gerald D. Artman, III, Scott D. Larsen
  • SYNTHESIS FOR THIAZOLIDINEDIONE COMPOUNDS
    Publication number: 20130211092
    Abstract: The present invention provides novel methods for synthesizing PPAR? sparing compounds, e.g., thiazolidinediones, that are useful for preventing and/or treating metabolic disorders such as diabetes, obesity, hypertension, and inflammatory diseases.
    Type: Application
    Filed: August 9, 2011
    Publication date: August 15, 2013
    Applicant: METABOLIC SOLUTIONS DEVELOPMENT COMPANY LLC
    Inventors: Steven P. Tanis, Timothy Parker, Robert C. Gadwood, James R. Zeller, Gerald D. Artman, III, Scott D. Larsen
  • NOVEL SYNTHESIS FOR THIAZOLIDINEDIONE COMPOUNDS
    Publication number: 20130204008
    Abstract: The present invention provides novel methods for synthesizing PPAR? sparing compounds, e.g., thiazolidinediones, that are useful for preventing and/or treating metabolic disorders such as diabetes, obesity, hypertension, and inflammatory diseases.
    Type: Application
    Filed: August 9, 2011
    Publication date: August 8, 2013
    Applicant: Metabolic Solutions Development Company, LLC
    Inventors: Steven P. Tanis, Timothy Parker, Robert C. Gadwood, Gerald D. Artman, III, James R. Zeller