Patents by Inventor Gerald D. Cagle

Gerald D. Cagle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10350309
    Abstract: The present invention relates to a process for preparing an ointment comprising subjecting a mixture of a fluorescent molecular rotor compound, mineral oil, and grinding media to ball milling agitation and combining this mixture with a hydrophobic vehicle for an ointment. The invention also relates to an ophthalmic formulation comprising a pharmaceutically acceptable carrier and a compound of the following structural Formula (I), or a pharmaceutically acceptable salt thereof: Values and preferred values of the variables in structural Formula (I) are described herein.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: July 16, 2019
    Assignee: Cognoptix, Inc.
    Inventors: Haresh Bhagat, Gerald D. Cagle, Francis X. Smith, Paul D. Hartung
  • Publication number: 20180126008
    Abstract: The present invention relates to a process for preparing an ointment comprising subjecting a mixture of a fluorescent molecular rotor compound, mineral oil, and grinding media to ball milling agitation and combining this mixture with a hydrophobic vehicle for an ointment. The invention also relates to an ophthalmic formulation comprising a pharmaceutically acceptable carrier and a compound of the following structural Formula (I), or a pharmaceutically acceptable salt thereof: Values and preferred values of the variables in structural Formula (I) are described herein.
    Type: Application
    Filed: January 8, 2018
    Publication date: May 10, 2018
    Inventors: Haresh Bhagat, Gerald D. Cagle, Francis X. Smith, Paul D. Hartung
  • Publication number: 20180092882
    Abstract: The present invention is directed to topical ophthalmic compositions of a lipophilic compound and an oligomeric or polymeric carrier wherein the compositions are useful in the treatment and prevention of macular degeneration. The invention also includes methods of treating macular degeneration by using a topical ophthalmic composition of a lipophilic compound and an oligomeric or polymeric carrier.
    Type: Application
    Filed: October 12, 2017
    Publication date: April 5, 2018
    Inventors: Thomas A. Jordan, John Clifford Chabala, Gerald D. Cagle
  • Patent number: 9814701
    Abstract: The present invention is directed to topical ophthalmic compositions of a lipophilic compound and an oligomeric or polymeric carrier wherein the compositions are useful in the treatment and prevention of macular degeneration. The invention also includes methods of treating macular degeneration by using a topical ophthalmic composition of a lipophilic compound and an oligomeric or polymeric carrier.
    Type: Grant
    Filed: December 9, 2010
    Date of Patent: November 14, 2017
    Assignee: Aldeyra Therapeutics, Inc.
    Inventors: Thomas A. Jordan, John Clifford Chabala, Gerald D. Cagle
  • Publication number: 20170172974
    Abstract: A method of delivering a nasal spray. A sprayer having a formulation comprising olopatadine is provided. A spray of the formulation is delivered to a subject's nose. The spray may have a spray characteristic comprising a spray pattern having a longest axis of 20-45 mm, a shortest axis of 14-20 mm, and an ellipticity of 1-1.8. The spray may also have a spray characteristic comprising a droplet size distribution having a D10 of 15-30 ?m, a D50 of 30-60 ?m, a D90 of 50-150 ?m, a SPAN of not more than 3, and a % Volume of <10 ?m of less than 4%.
    Type: Application
    Filed: March 3, 2017
    Publication date: June 22, 2017
    Inventors: Gerald D. Cagle, G. Michael Wall
  • Patent number: 9451909
    Abstract: In accordance with an embodiment of the invention, there is provided a device and method for detecting an amyloid protein in an eye of a mammal. A method comprises illuminating the eye with a light source having at least one of a wavelength property, a polarization property or a combination thereof, each appropriate to produce fluorescence in at least an amyloid-binding compound when the amyloid-binding compound is bound to the amyloid protein, the amyloid-binding compound having been introduced to the eye and specifically binding to the amyloid protein indicative of the amyloidogenic disorder; and determining a time decay rate of fluorescence for at least the fluorescence produced by the amyloid-binding compound bound to the amyloid protein, the determining permitting distinguishing of the presence of the amyloid-binding compound bound to the amyloid protein in the eye based on at least the time decay rate.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: September 27, 2016
    Assignee: Cognoptix, Inc.
    Inventors: Paul D. Hartung, Vincent Valvo, Charles Kerbage, Gerald D. Cagle, Dennis J. Nilan
  • Publication number: 20160183859
    Abstract: In accordance with an embodiment of the invention, there is provided a device and method for detecting an amyloid protein in an eye of a mammal. A method comprises illuminating the eye with a light source having at least one of a wavelength property, a polarization property or a combination thereof, each appropriate to produce fluorescence in at least an amyloid-binding compound when the amyloid-binding compound is bound to the amyloid protein, the amyloid-binding compound having been introduced to the eye and specifically binding to the amyloid protein indicative of the amyloidogenic disorder; and determining a time decay rate of fluorescence for at least the fluorescence produced by the amyloid-binding compound bound to the amyloid protein, the determining permitting distinguishing of the presence of the amyloid-binding compound bound to the amyloid protein in the eye based on at least the time decay rate.
    Type: Application
    Filed: December 1, 2015
    Publication date: June 30, 2016
    Inventors: Paul D. Hartung, Vincent Valvo, Charles Kerbage, Gerald D. Cagle, Dennis J. Nilan
  • Patent number: 9220403
    Abstract: In accordance with an embodiment of the invention, there is provided a device and method for detecting an amyloid protein in an eye of a mammal. A method comprises illuminating the eye with a light source having at least one of a wavelength property, a polarization property or a combination thereof, each appropriate to produce fluorescence in at least an amyloid-binding compound when the amyloid-binding compound is bound to the amyloid protein, the amyloid-binding compound having been introduced to the eye and specifically binding to the amyloid protein indicative of the amyloidogenic disorder; and determining a time decay rate of fluorescence for at least the fluorescence produced by the amyloid-binding compound bound to the amyloid protein, the determining permitting distinguishing of the presence of the amyloid-binding compound bound to the amyloid protein in the eye based on at least the time decay rate.
    Type: Grant
    Filed: August 12, 2011
    Date of Patent: December 29, 2015
    Assignee: Cognoptix, Inc.
    Inventors: Paul D. Hartung, Vincent Valvo, Charles Kerbage, Gerald D. Cagle, Dennis J. Nilan
  • Publication number: 20150118163
    Abstract: The present invention relates to a process for preparing an ointment comprising subjecting a mixture of a fluorescent molecular rotor compound, mineral oil, and grinding media to ball milling agitation and combining this mixture with a hydrophobic vehicle for an ointment. The invention also relates to an ophthalmic formulation comprising a pharmaceutically acceptable carrier and a compound of the following structural Formula (I), or a pharmaceutically acceptable salt thereof: Values and preferred values of the variables in structural Formula (I) are described herein.
    Type: Application
    Filed: October 30, 2014
    Publication date: April 30, 2015
    Inventors: Haresh Bhagat, Gerald D. Cagle, Francis X. Smith, Paul D. Hartung
  • Publication number: 20140227326
    Abstract: A method of delivering a nasal spray. A sprayer having a formulation comprising olopatadine is provided. A spray of the formulation is delivered to a subject's nose. The spray may have a spray characteristic comprising a spray pattern having a longest axis of 20-45 mm, a shortest axis of 14-20 mm, and an ellipticity of 1-1.8. The spray may also have a spray characteristic comprising a droplet size distribution having a D10 of 15-30 ?m, a D50 of 30-60 ?m, a D90 of 50-150 ?m, a SPAN of not more than 3, and a % Volume of <10 ?m of less than 4%.
    Type: Application
    Filed: November 14, 2013
    Publication date: August 14, 2014
    Applicant: Novartis AG
    Inventors: Gerald D. Cagle, G. Michael Wall
  • Publication number: 20130135580
    Abstract: In accordance with an embodiment of the invention, there is provided a device and method for detecting an amyloid protein in an eye of a mammal. A method comprises illuminating the eye with a light source having at least one of a wavelength property, a polarization property or a combination thereof, each appropriate to produce fluorescence in at least an amyloid-binding compound when the amyloid-binding compound is bound to the amyloid protein, the amyloid-binding compound having been introduced to the eye and specifically binding to the amyloid protein indicative of the amyloidogenic disorder; and determining a time decay rate of fluorescence for at least the fluorescence produced by the amyloid-binding compound bound to the amyloid protein, the determining permitting distinguishing of the presence of the amyloid-binding compound bound to the amyloid protein in the eye based on at least the time decay rate.
    Type: Application
    Filed: August 12, 2011
    Publication date: May 30, 2013
    Inventors: Paul D. Hartung, Vincent Valvo, Charles Kerbage, Gerald D. Cagle, Dennis J. Nilan
  • Publication number: 20120302601
    Abstract: The present invention is directed to topical ophthalmic compositions of a lipophilic compound and an oligomeric or polymeric carrier wherein the compositions are useful in the treatment and prevention of macular degeneration. The invention also includes methods of treating macular degeneration by using a topical ophthalmic composition of a lipophilic compound and an oligomeric or polymeric carrier.
    Type: Application
    Filed: December 9, 2010
    Publication date: November 29, 2012
    Applicant: Neuron Systems, Inc.
    Inventors: Thomas A. Jordan, John Clifford Chabala, Gerald D. Cagle
  • Patent number: 8080028
    Abstract: A surgical knife blade or other surgical device containing an anti-microbial coating. The coating may be adhered to the device by a water-soluble adhesive that allows the anti-microbial coating to be released into the wound track. The coating may be of a consistency that allows a certain amount of the coating to slough off and pool or puddle around the surgical site as the surgical device is moved into and out of the surgical site.
    Type: Grant
    Filed: December 5, 2005
    Date of Patent: December 20, 2011
    Assignee: Novartis AG
    Inventor: Gerald D. Cagle
  • Publication number: 20040126436
    Abstract: Compositions for assisting in the removal of human cerumen are disclosed. The compositions may include bicarbonate and an otologically acceptable vehicle; a cerumenolytically acceptable enzyme and an otologically acceptable vehicle; or bicarbonate, a cerumenolytically acceptable enzyme, and an otologically acceptable vehicle.
    Type: Application
    Filed: November 10, 2003
    Publication date: July 1, 2004
    Inventors: Gerald D. Cagle, Geoffrey R. Owen, Nuria Jimenez Ridruejo, G. Michael Wall
  • Publication number: 20040097474
    Abstract: Compositions and methods for treating rhinitis with certain combinations of antiallergic agents and steroids are disclosed.
    Type: Application
    Filed: November 12, 2003
    Publication date: May 20, 2004
    Applicant: Alcon, Inc.
    Inventors: Gerald D. Cagle, G. Michael Wall, John M. Yanni, Rajni Jani, Haresh G. Bhagat
  • Publication number: 20040033208
    Abstract: Antimicrobial compositions containing one or more topically active antibiotics (e.g., Natamycin) and one or more amidoamines are described. The amidoamines enhance or supplement the antimicrobial activity of natamycin or other topically active antibiotics. The compositions are particularly useful in treating or preventing fungal infections of the eye, ear, nose and throat, as well as sterilizing these tissues prior to surgery or other medical procedures.
    Type: Application
    Filed: May 22, 2003
    Publication date: February 19, 2004
    Inventors: Gerald D. Cagle, Barry A. Schlech, Joseph W. Hiddene, G. Michael Wall
  • Publication number: 20030199590
    Abstract: Methods and compositions for the promotion of hair growth in mammals, comprising PGF2&agr; analogues are disclosed.
    Type: Application
    Filed: November 6, 2002
    Publication date: October 23, 2003
    Inventors: Gerald D Cagle, Michael V.W. Bergamini
  • Patent number: 6630135
    Abstract: An improved method of sterilizing the field of surgery prior to an ophthalmic surgical procedure is described. The invention eliminates the need for painful and potentially traumatic injections of antibiotics by utilizing sustained release compositions which allow the antibiotics contained therein to penetrate deeply into the eye, thereby ensuring a sterile field of surgery during intraocular surgical procedures. The compositions may also be utilized to prevent post-surgical infections.
    Type: Grant
    Filed: November 12, 1999
    Date of Patent: October 7, 2003
    Assignee: Alcon Laboratories, Inc.
    Inventors: Gerald D. Cagle, Tai-Lee Ke, Barry A. Schlech, Ole J. Lorenzetti
  • Patent number: 6261547
    Abstract: Ophthalmic drug delivery vehicles which are administrable as a liquid and which gel upon contact with the eye are disclosed. The vehicles contain xanthan gum and an ophthalmically acceptable anesthetic agent.
    Type: Grant
    Filed: November 23, 1999
    Date of Patent: July 17, 2001
    Assignee: Alcon Manufacturing, Ltd.
    Inventors: Rajan Bawa, Rex E. Hall, Bhagwati P. Kabra, James E. Teague, Gerald D. Cagle, Kerry L. Markwardt, Mandar V. Shah
  • Patent number: 5985259
    Abstract: An improved method of sterilizing the field of surgery prior to an ophthalmic surgical procedure is described. The invention eliminates the need for painfull and potentially traumatic injections of antibiotics by utilizing sustained release compositions which allow the antibiotics contained therein to penetrate deeply into the eye, thereby ensuring a sterile field of surgery during intraocular surgical procedures. The compositions may also be utilized to prevent post-surgical infections.
    Type: Grant
    Filed: April 30, 1997
    Date of Patent: November 16, 1999
    Assignee: Alcon Laboratories, Inc.
    Inventors: Gerald D. Cagle, Tai-Lee Ke, Barry A. Schlech, Ole J. Lorenzetti