Abstract: Provided herein are various methods for identifying candidate substrates for the E3 ligase machinery.

Abstract: Systems and methods for creating multi-spot laser light beams, multiplexing an illumination light and the multi-spot laser light beams, delivering the multiplexed light to a surgical handpiece via a multi-core optical fiber cable, and delivering the multiplexed light onto patient anatomy.

Abstract: Systems and methods for creating multi-spot laser light beams, multiplexing an illumination light and the multi-spot laser light beams, delivering the multiplexed light to a surgical handpiece via a multi-core optical fiber cable, and delivering the multiplexed light onto patient anatomy.

Abstract: A modular pallet for a textile printing machine, to hold textile products of different shapes and sizes to allow for effective printing on the products, the modular pallet having two parts, a first part which is fixed to the printing machine and is designed for removably fitting a second, modular part. The second part is made up of a range of exchangeable parts which are shaped and configured for different textile products. Each exchangeable part is able to fit into the first part, so that the pallet can be modified for printing different textile products.

Abstract: A catheter system (100) includes an inflatable balloon (104), an optical fiber (122), and a laser (124). The optical fiber (122) has a distal end positioned within the inflatable balloon (104). The optical fiber (122) receives an energy pulse (431) to emit light energy in a direction away from the optical fiber (122) to generate a plasma pulse (134) within the inflatable balloon (104). The laser (124) includes a seed source (126) that emits a seed pulse (342) and an amplifier (128) that increases energy of the seed pulse (342) so that the laser (124) generates the energy pulse (431) that is received by the optical fiber (122), the energy pulse (431) having a waveform with a duration T, a minimum power PO, a peak power PP, and a time from PO to PP equal to TP.

Abstract: A catheter system (100) includes a light guide (122A) and a light source (124). The light guide (122A) is configured to selectively receive light energy. The light source (124) generates the light energy. The light source (124) is in optical communication with the light guide (122A). The light source can include (i) a seed source (260) that outputs the light energy, (ii) a pre-amplifier (262) that receives the light energy from the seed source (260), the pre-amplifier (262) being in optical communication with the seed source (260), and (iii) an amplifier (264) that receives the light energy from the pre-amplifier (262), the amplifier (264) being in optical communication with the pre-amplifier (262) and the light guide (122A).

Abstract: Certain embodiments describe an endoilluminator comprising a probe housing an optical fiber. The probe comprises a distal end with an opening through which a first light from a distal end of the optical fiber is configured to be propagated. The probe comprises one or more side openings through which a second light from one or more sides of the optical fiber is configured to be propagated. The endoilluminator also comprises a handpiece coupled to a light source and the proximal end of the probe, wherein the light source is configured to drive light into the optical fiber.

Abstract: In certain embodiments, a system for sensing occlusions in an optical system includes a first laser source configured to generate optical signals and a set of optical elements arranged to receive the optical signals from the first laser source and to direct the optical signals along a beam path. The system also includes a detector arranged to receive reflections of the optical signals traveling along at least a portion of the beam path and a control system communicably coupled to the detector. The control system is configured to detect, based on signals generated by the detector, reflection signals associated with the reflections of the optical signals, and disable a second laser source based on detection of the reflection signals.

Abstract: A pallet for holding garments during printing comprises a base and a frame pivotally attached to the base, to hold a garment in a space between the base and the frame, the frame being locked onto the base over the garment to define the space. The pallet comprises a primary locking mechanism to lock the frame into a first position defining a relatively small space for a thin garment and a secondary locking mechanism for locking the frame into a second position defining a relatively large space for thicker garments, thereby providing a single pallet that can accommodate garments of a larger range of thicknesses, for example t-shirts and sweaters or hoodies.

Abstract: A pallet for holding garments during printing comprises a base and a frame pivotally attached to the base, to hold a garment in a space between the base and the frame, the frame being locked onto the base over the garment to define the space. The pallet comprises a primary locking mechanism to lock the frame into a first position defining a relatively small space for a thin garment and a secondary locking mechanism for locking the frame into a second position defining a relatively large space for thicker garments, thereby providing a single pallet that can accommodate garments of a larger range of thicknesses, for example t-shirts and sweaters or hoodies.

Abstract: A catheter system includes an inflatable balloon, an optical fiber and a laser. The optical fiber has a distal end positioned within the inflatable balloon. The optical fiber receives an energy pulse to emit light energy in a direction away from the optical fiber to generate a plasma pulse within the inflatable balloon. The laser includes a seed source that emits a seed pulse, and an amplifier that increases energy of the seed pulse. The energy pulse can have a somewhat square or triangular waveform with a duration T, a minimum power P0, a peak power PP, and a time from P0 to PP equal to TP, wherein TP is not greater than 40% of T. T can be within the range of greater than 50 ns and less than 3 ?s. TP can be within the range of greater than 2.5 ns and less than 1 ?s. PP can be within the range of greater than 50 kW and less than 1000 kW. A ratio in kW to ns of PP to TP can be greater than 1:5. The seed pulse can at least partially increase in amplitude over time.

Abstract: According to one general aspect, an apparatus may include a branch prediction circuit configured to predict if a branch instruction will be taken or not. The apparatus may include a branch target buffer circuit configured to store a memory segment empty flag that indicates whether or not the memory segment after a target address includes at least one other branch instruction, wherein the memory segment empty flag was created during a commit stage of a prior occurrence of the branch instruction. The branch prediction circuit may be configured to skip over the memory segment if the memory segment empty flag indicates a lack of other branch instruction(s).

Abstract: A ramp kerb, for supporting a transverse edge of a ramp surface and a ramp lip extension having an attachment portion, comprises a first longitudinally extending channel open at an inner transverse edge of the ramp kerb for receiving a transverse edge of the ramp surface and a second longitudinally extending channel open at the inner transverse edge of the ramp kerb for receiving an attachment portion of the ramp lip extension. The first and second longitudinally extending channels are vertically spaced.

Abstract: Certain embodiments describe an endoilluminator comprising a probe housing an optical fiber. The probe comprises a distal end with an opening through which a first light from a distal end of the optical fiber is configured to be propagated. The probe comprises one or more side openings through which a second light from one or more sides of the optical fiber is configured to be propagated. The endoilluminator also comprises a handpiece coupled to a light source and the proximal end of the probe, wherein the light source is configured to drive light into the optical fiber.

Abstract: Mechanical optics for mode mixing may be used to homogenize different modes in an optical fiber used for surgical illumination. A mechanical optical element, such as a rotating prism or a mirror membrane, may impart motion to an incident beam entering the optical fiber to generate a homogeneous illumination field from a coherent light source.

Abstract: Pixelated array optics for mode mixing may be used to homogenize different modes in an optical fiber used for surgical illumination. A pixelated phase array, such as a digital micromirror device or an LCD phase plate, may impart motion to an incident beam entering the optical fiber to generate a homogeneous illumination field from a coherent light source.

Abstract: Systems and methods are disclosed for measuring pulsed laser output. An example system comprises a laser configured to emit output in pulses; at least one sensor positioned to sense laser output and configured to convert that output into electrical signals; an edge detector configured to detect at least leading edges of a plurality of laser pulses; an analog to digital converter configured to convert electrical signals from a sensor into digital signals indicative of laser power output; and a controller; wherein, based on the detection of at least the leading edges of the laser pulses, the controller is configured to obtain samples of laser power output during the laser pulses. The system may refrain from sampling laser power output between laser pulses or may sample laser power output between laser pulses at a reduced sample rate. The system may use the samples of laser power output in a feedback loop to automatically adjust laser power.