Abstract: Systems and methods for managing, analyzing, and evaluating clinical trials. Clinical trial data collection, management, review, and analysis may be performed independent of the clinical trial. A clinical trial manager may have a study review and management application and a clinical trial database. The study review and management application may have a protocol selecting engine, a data collection engine, and a data analysis engine. The data collection engine may have a communication routine and documentation routine for collecting data and documenting the data in the clinical trial database. The data analysis engine may have a categorization routine and analysis routine for categorizing and analyzing the data collected by the data collection engine. The clinical trial manager may be accessible via a user interface.