Patents by Inventor Gerald E. Gutowski

Gerald E. Gutowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms
    Patent number: 4357334
    Abstract: VLB 3-(2-chloroethyl)carboxamide, the corresponding 4-desacetyl derivative and salts thereof, useful in treatment of neoplasms in pharmaceutical dosage forms.
    Type: Grant
    Filed: March 20, 1980
    Date of Patent: November 2, 1982
    Assignee: Eli Lilly and Company
    Inventors: Jean C. Miller, Gerald E. Gutowski
  • Vinca alkaloid intermediates
    Patent number: 4160767
    Abstract: 3-Spiro-5"-oxazolidine-2",4"-dione derivatives of Vinca alkaloids, useful as anti-tumor agents and as intermediates.
    Type: Grant
    Filed: August 21, 1978
    Date of Patent: July 10, 1979
    Assignee: Eli Lilly and Company
    Inventors: Jean C. Miller, Gerald E. Gutowski
  • Oxazolidinedione derivatives of Vinca alkaloids
    Patent number: 4096148
    Abstract: 3-Spiro-5"-oxazolidine-2",4"-dione derivatives of Vinca alkaloids, useful as anti-tumor agents and as intermediates.
    Type: Grant
    Filed: December 6, 1976
    Date of Patent: June 20, 1978
    Assignee: Eli Lilly and Company
    Inventors: Jean C. Miller, Gerald E. Gutowski
  • 5' Acetoxy vinblastine 4' bis-sulfite
    Patent number: 4087429
    Abstract: Vincaleukoblastine (VLB, vinblastine) is reacted with thionyl chloride to form a bis-sulfite ester which is converted to various 5'-oxygenated derivatives.
    Type: Grant
    Filed: October 20, 1976
    Date of Patent: May 2, 1978
    Assignee: Eli Lilly and Company
    Inventors: Allen S. Katner, Gerald E. Gutowski, Jean C. Miller
  • Preparation of leurosidine and novel leurosidine 4'-ethers and esters
    Patent number: 4075214
    Abstract: Vincaleukoblastine (VLB, vinblastine) is converted to leurosidine, its 4' epimer, by reaction with thionyl chloride to form a bis-sulfite ester followed by treatment of the bis-sulfite ester with silver perchlorate. The bis-sulfite ester is covertible to novel 4' ethers by treatment with a lower alkanol or 4' esters of leurosidine perchlorate with acetic anhydride.
    Type: Grant
    Filed: May 17, 1976
    Date of Patent: February 21, 1978
    Assignee: Eli Lilly and Company
    Inventors: Allen S. Katner, Gerald E. Gutowski, Jean C. Miller
  • Acylation of pyrazofurin
    Patent number: 4053698
    Abstract: A process for preparing new compounds which are N- and O-acylates of pyrazofurin comprises first selective mono-N-acylation under non-basic conditions in an organic solvent. The mono-N-acylate so formed is further acylated under mild basic conditions to provide a tetra-acylated or penta-acylated pyrazofurin derivative, depending upon the duration of reaction. Mild solvolysis of either a tetra-acylate or a penta-acylate provides a tri-acylated pyrazofurin derivative. In the presence of a strong base, the mono-N-acylate is further acylated to provide different tetra-acylates or penta-acylates of pyrazofurin, again depending upon the duration of reaction. Pyrazofurin acylates are useful as antiviral, antipsoriatic, and antifungal agents, as well as intermediates for new C-nucleosides.
    Type: Grant
    Filed: February 23, 1976
    Date of Patent: October 11, 1977
    Assignee: Eli Lilly and Company
    Inventor: Gerald E. Gutowski
  • Dimeric anhydro-vinca derivatives
    Patent number: 4029663
    Abstract: Dimeric Vinca alkaloids are converted to three separable anhydro derivatives, useful as mitotic inhibitors or as intermediates for the preparation of other oncogenetically active alkaloids.
    Type: Grant
    Filed: July 10, 1975
    Date of Patent: June 14, 1977
    Assignee: Eli Lilly and Company
    Inventors: Gerald E. Gutowski, Jean C. Miller
  • Acylated derivatives of pyrazofurin and process for their preparation
    Patent number: 3960836
    Abstract: A process for preparing new compounds which are N- and O-acylates of pyrazofurin comprises first selective mono-N-acylation under non-basic conditions in an organic solvent. The mono-N-acylate so formed is further acylated under mild basic conditions to provide a tetra-acylated or penta-acylated pyrazofurin derivative, depending upon the duration of reaction. Mild solvolysis of either a tetra-acylate or a penta-acylate provides a tri-acylated pyrazofurin derivative. In the presence of a strong base, the mono-N-acylate is further acylated to provide different tetra-acylates or penta-acylates of pyrazofurin, again depending upon the duration of reaction. Pyrazofurin acylates are useful as antiviral, antipsoriatic, and antifungal agents, as well as intermediates for new C-nucleosides.
    Type: Grant
    Filed: July 22, 1974
    Date of Patent: June 1, 1976
    Assignee: Eli Lilly and Company
    Inventor: Gerald E. Gutowski
  • Oxazolidinedione derivatives of Vinca alkaloids
    Patent number: RE30560
    Abstract: 3-Spiro-5"-oxazolidine-2",4"-dione derivatives of Vinca alkaloids, useful as anti-tumor agents and as intermediates.
    Type: Grant
    Filed: November 2, 1979
    Date of Patent: March 31, 1981
    Assignee: Eli Lilly and Company
    Inventors: Jean C. Miller, Gerald E. Gutowski
  • Vinca alkaloid intermediates
    Patent number: RE30561
    Abstract: 3-Spiro-5"-oxazolidine-2",4"-dione derivatives of Vinca alkaloids, useful as anti-tumor agents and as intermediates.
    Type: Grant
    Filed: November 2, 1979
    Date of Patent: March 31, 1981
    Assignee: Eli Lilly and Company
    Inventors: Jean C. Miller, Gerald E. Gutowski