Patents by Inventor Gerald E. Koelsch

Gerald E. Koelsch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF
    Publication number: 20100267609
    Abstract: Compounds inhibit memapsin 2 ?-secretase activity and selectively inhibit memapsin 2 ?-secretase activity relative to memapsin 1 ?-secretase activity. The compounds are employed in methods to inhibit memapsin 2 ?-secretase activity, in the treatment of Alzheimer's disease, in the inhibition of hydrolysis of a ?-secretase site of a ?-amyloid precursor protein and to decrease ?-amyloid protein in in vitro samples and in mammals. Proteins of memapsin 2 associated with compounds of the invention are crystallized.
    Type: Application
    Filed: June 9, 2009
    Publication date: October 21, 2010
    Inventors: Arun K. GHOSH, Jordan J. N. Tang, Geoffrey Bilcer, Wanpin Chang, Lin Hong, Gerald E. Koelsch, Jeffrey A. Loy, Robert T. Turner, III, Thippeswamy Devasumadram
  • Compounds which inhibit beta-secretase activity and methods of use thereof
    Publication number: 20040121947
    Abstract: Compounds inhibit memapsin 2 &bgr;-secretase activity and selectively inhibit memapsin 2 &bgr;-secretase activity relative to memapsin 1 &bgr;-secretase activity. The compounds are employed in methods to inhibit memapsin 2 &bgr;-secretase activity, in the treatment of Alzheimer's disease, in the inhibition of hydrolysis of a &bgr;-secretase site of a &bgr;amyloid precursor protein and to decrease &bgr;-amyloid protein in in vitro samples and in mammals. Proteins of memapsin 2 associated with compounds of the invention are crystallized.
    Type: Application
    Filed: October 23, 2002
    Publication date: June 24, 2004
    Applicants: Oklahoma Medical Research Foundation, The Board of Trustees of the University of Illinois
    Inventors: Arun K. Ghosh, Jordan J. N. Tang, Geoffrey Bilcer, Wanpin Chang, Lin Hong, Gerald E. Koelsch, Jeffrey A. Loy, Robert T. Turner, Thippeswamy Devasumadram