Patents by Inventor Gerald E. Stokker

Gerald E. Stokker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted 2,2-dioxo-1,2,3-benzoxathiazines
    Patent number: 4166177
    Abstract: The invention relates to novel 2,2-dioxo-1,2,3-benzoxathiazines substituted in the benzene nucleus, as well as the 3,4-dihydro analogs thereof, useful as anti-inflammatory, antipyretic, analgesic agents.
    Type: Grant
    Filed: December 27, 1977
    Date of Patent: August 28, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., Robert L. Smith, Gerald E. Stokker
  • Nuclear substituted 2-hydroxyphenylmethanesulfamic acids
    Patent number: 4159279
    Abstract: Nuclear substituted 2-hydroxyphenylmethanesulfamic acids and their pharmaceutically acceptable salts wherein the phenyl nucleus is substituted with 2 to 4 nuclear substituents and which are useful saluretic-diuretics and anti-inflammatories are disclosed. The products may be prepared by reacting nuclear substituted salicylaldehydes with ammonium sulfamate to generate intermediate imines which are reduced to afford the compounds of this invention.
    Type: Grant
    Filed: November 23, 1977
    Date of Patent: June 26, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Robert L. Smith, Gerald E. Stokker, Edward J. Cragoe, Jr.
  • Derivatives of 1,2-benzisoxazoles
    Patent number: 4156005
    Abstract: Substituted 1,2-benzisoxazoles of the formula ##STR1## where: R.sup.1 and R.sup.3 =H or lower alkoxy;R.sup.2 =halo or .alpha.-branched lower alkyl;R.sup.4 =halo, halo lower alkyl, or lower alkylthio; provided, where R.sup.1 and R.sup.3 =H,R.sup.2 and R.sup.4 are other than simultaneously Cl or Br, which are active as antiinflammatory, antipyretic and analgesic agents, are derived from cyclodehydrating the corresponding salicylaldoximes with an isocyanate under extremely mild conditions.
    Type: Grant
    Filed: June 21, 1978
    Date of Patent: May 22, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Gerald E. Stokker, Edward J. Cragoe, Jr.
  • 2-Halo-4-aminomethyl-6-alkyl-3-pyridinols useful as diuretics in treating hypertension and edema
    Patent number: 4123537
    Abstract: Certain substituted 4-aminomethyl-3-pyridinols and their pharmaceutically acceptacle acid addition salts wherein the pyridinol nucleus may be further substituted with 1 to 2 nuclear substituents are useful as antihypertensive, diuretic and saluretic agents. These products may be prepared by halogenating an appropriately substituted pyridine salt.
    Type: Grant
    Filed: May 26, 1977
    Date of Patent: October 31, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Robert L. Smith, Gerald E. Stokker, Edward J. Gragoe, Jr.
  • Substituted 2-aminomethylphenyl sulfamates
    Patent number: 4113877
    Abstract: Substituted 2-aminomethylphenyl sulfamates and pharmaceutically acceptable acid addition salts wherein the sulfamate group is N-substituted with up to 2 groups and the phenyl nucleus is further substituted by from 2 to 4 nuclear substituents which are useful as diuretics and saluretics are disclosed. The products may be prepared by reacting a N-protected substituted 2-aminomethylphenol with a substituted sulfamoyl chloride to generate an intermediate which is N-deblocked to give the compounds of this invention.
    Type: Grant
    Filed: September 16, 1977
    Date of Patent: September 12, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Robert L. Smith, Gerald E. Stokker, Edward J. Cragoe, Jr.
  • 3,4-Dihydrospiro-2H-1,3-benzoxazines and their use in treating edema, abnormal electrolyte retention, and inflammation
    Patent number: 4092414
    Abstract: 3,4-Dihydrospiro-2H-1,3-benzoxazines are prepared by condensing aminomethylphenols with cyclic ketones. The products are diuretic and anti-inflammatory agents, and are useful in the treatment of autoimmune diseases, such as multiple sclerosis.
    Type: Grant
    Filed: February 19, 1976
    Date of Patent: May 30, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., Everett M. Schultz, Gerald E. Stokker
  • Spirobenzoxazinium salts, method of use and compositions thereof as antihypertensive agents
    Patent number: 4067980
    Abstract: Quaternary salts of 3,4-dihydrospiro-2H-1,3-benzoxazines are prepared by treating 3,4-dihydrospiro-2H-1,3-benzoxazines with an alkylating agent. The products are antihypertensive agents.
    Type: Grant
    Filed: August 16, 1976
    Date of Patent: January 10, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., Gerald E. Stokker, Everett M. Schultz
  • (1-Oxo-7,8-disubstituted-1,2,3,4-tetrahydro-6-naphthyloxy)- and (3,4-disubstituted-5-oxo-6,7,8,9-tetrahydro-5H-benzocycloheptene-2-yloxy ) acetic acids and derivatives
    Patent number: 4003927
    Abstract: (1-Oxo-7,8-disubstituted-1,2,3,4-tetrahydro-6-naphthyloxy)- and (3,4-disubstituted-5-oxo-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yloxy)ac etic acids, their carboxylate salts, and the amide and 5-tetrazole derivatives thereof are active as diuretic and saluretic agents, which also have uricosuric activity.
    Type: Grant
    Filed: October 12, 1973
    Date of Patent: January 18, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Otto W. Woltersdorf, Jr., Edward J. Cragoe, Jr., Everett M. Schultz, Gerald E. Stokker