Patents by Inventor Gerald H. Wagman

Gerald H. Wagman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antimicrobial compound isolated from Actinomadura fulva subsp indica
    Patent number: 4904644
    Abstract: A macrolactam disaccharide isolated from an antimicrobial complex 530 produced in fermentation under controlled conditions using a biologically pure culture of the microorganism Actinomadura fulva subsp. indica ATCC 53714.
    Type: Grant
    Filed: August 3, 1988
    Date of Patent: February 27, 1990
    Assignee: Schering Corporation
    Inventors: Vinod R. Hedge, Ann C. Horan, Arthur H. King, Frank A. Gentile, Mahesh G. Patel, Gerald H. Wagman
  • Antibiotic 67-121, a new polyene antifungal antibiotic produced by Actinoplanes caeruleus
    Patent number: 4359462
    Abstract: A microorganism of the genus Acetinoplanes produces a novel complex of polyene antibiotics herein designated collectively Antibiotic 67-121 (and sometimes referred to as the Antibiotic 67-121 complex). The individual components are designated Antibiotic 67-121A, Antibiotic 67-121B, Antibiotic 67-121C and Antibiotic 67-121D. The individual components have ultraviolet spectra characteristic of heptaenes. Further, they are orally active against a variety of strains of Candida albicans including many clinical isolates thereof.
    Type: Grant
    Filed: May 14, 1980
    Date of Patent: November 16, 1982
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Joseph A. Marquez, Mahesh G. Patel
  • Microbiological methylation of aminoglycosyl-aminoglycosides
    Patent number: 4348516
    Abstract: The microorganisms Micromonospora inyoensis 1550F-1G and M. purpurea strain 1124 each microbiologically convert tobramycin, kanamycin A, kanamycin B and dibekacin to their respective 3"-N-methyl and 3"-N-methyl-4"-C-methyl derivatives. The derivatives exhibit significant activity against representative gram positive and gram negative bacteria and may also be converted to other derivatives which have significant antibacterial activity.
    Type: Grant
    Filed: June 12, 1980
    Date of Patent: September 7, 1982
    Assignee: Schering Corporation
    Inventors: Bong K. Lee, Gerald H. Wagman, Dinanath F. Rane, Joseph A. Marquez, Peter J. L. Daniels
  • Method for producing rosaramicin (rosamicin)
    Patent number: 4234690
    Abstract: Rosaramicin, (also known as rosaramicin) a new broad spectrum antibiotic is described together with methods for its production via the cultivation under controlled conditions of Micromonospora rosaria, a new species of Micromonospora, and to methods for purifying and using the same. Its 2'-monoesters and its 3,2'-diesters and their acid addition salts also possess antibiotic activity.
    Type: Grant
    Filed: July 16, 1979
    Date of Patent: November 18, 1980
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Joseph A. Marquez
  • Microbiological methylation of aminoglycosyl-aminoglycosides
    Patent number: 4234685
    Abstract: The microorganisms Micromonospora inyoensis 1550F-1G and M. purpurea strain 1124 each microbiologically convert tobramycin, kanamycin A, kanamycin B and dibekacin to their respective 3"-N-methyl and 3"-N-methyl-4"-C-methyl derivatives. The derivatives exhibit significant activity against representative gram positive and gram negative bacteria and may also be converted to other derivatives which have significant antibacterial activity.
    Type: Grant
    Filed: June 25, 1979
    Date of Patent: November 18, 1980
    Assignee: Schering Corporation
    Inventors: Bong K. Lee, Gerald H. Wagman, Dinanath F. Rane, Joseph A. Marquez, Peter J. L. Daniels
  • Antibiotic 67-121, a polyene antifungal antibiotic produced by Actinoplanes caeruleus
    Patent number: 4223130
    Abstract: A microorganism of the genus Actinoplanes produces a novel complex of polyene antibiotics herein designated collectively Antibiotic 67-121 (and sometimes referred to as the Antibiotic 67-121 complex). The individual components are designated Antibiotic 67-121A, Antibiotic 67-121B, Antibiotic 67-121C and Antibiotic 67-121D. The individual components have ultraviolet spectra characteristic of heptaenes. Further, they are orally active against a variety of strains of Candida albicans including many clinical isolates thereof.
    Type: Grant
    Filed: September 28, 1978
    Date of Patent: September 16, 1980
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Joseph A. Marquez, Mahesh G. Patel
  • Rosamicin esters, acid addition salts and methods for production thereof
    Patent number: 4161523
    Abstract: Antibiotic 67-694, (also known as rosamicin) a new broad spectrum antibiotic is described together with methods for its production via the cultivation under controlled conditions of Micromonospora rosaria, a new species of Micromonospora, and to methods for purifying and using the same. Its 2'-monoesters and its 3,2'-diesters and their acid addition salts also possess antibiotic activity.
    Type: Grant
    Filed: October 21, 1974
    Date of Patent: July 17, 1979
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Joseph A. Marquez
  • Antibiotic complex from micromonospora arborensis
    Patent number: 4078056
    Abstract: Micromonospora arborensis produces a plurality of antibiotics named herein antibiotic 68-1147 complex, when cultivated under controlled aerobic conditions. Two of the antibiotics, antibiotic 68-1147 I and antibiotic 68-1147 II are described and shown to be effective antibacterial agents, especially against gram positive bacteria.
    Type: Grant
    Filed: February 2, 1976
    Date of Patent: March 7, 1978
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Joseph A. Marquez, Raymond T. Testa
  • Antibiotic 67-121, a polyene antifungal antibiotic produced by actinoplanes caeruleus
    Patent number: 4027015
    Abstract: A microorganism of the genus Actinoplanes produces a novel complex of polyene antibiotics herein designated collectively Antibiotic 67-121 (and sometimes referred to as the Antibiotic 67-121 complex). The individual components are designated Antibiotic 67-121A, Antibiotic 67-121B, Antibiotic 67-121C and Antibiotic 67-121D. The individual components have ultraviolet spectra characteristic of heptaenes. Further, they are orally active against a variety of strains of Candida albicans including many clinical isolates thereof.
    Type: Grant
    Filed: June 9, 1975
    Date of Patent: May 31, 1977
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Joseph A. Marquez, Mahesh G. Patel
  • Semi-synthetic aminocyclitol aminoglycoside antibiotics and methods for the preparation thereof
    Patent number: 4011390
    Abstract: Micromonospora inyoensis strain 1550F-1G NRRL 5742 is incapable of producing antibiotics unless an aminocyclitol is added to the fermentation medium. When such a compound is added, mutamicins are produced, said mutamicins being analogs of known aminoglycoside antibiotics differing therefrom with respect to the aminocyclitol subunit.
    Type: Grant
    Filed: June 5, 1974
    Date of Patent: March 8, 1977
    Assignee: Schering-Plough Corporation
    Inventors: Marvin J. Weinstein, Peter J. L. Daniels, Gerald H. Wagman, Raymond Testa
  • Antibiotic G-52 and method for the production thereof
    Patent number: 4001209
    Abstract: A novel actinomycete herein designated Micromonospora zionensis elaborates a product having substantial antibacterial activity, said activity being due to sisomicin and the novel antibiotic substance coproduced therewith. The disclosure sets forth methods for producing, isolating and using the antibiotics.
    Type: Grant
    Filed: February 28, 1975
    Date of Patent: January 4, 1977
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Joseph A. Marquez
  • Antibiotic G-418 and the production thereof
    Patent number: 3997403
    Abstract: A novel actinomycete herein designated Micromonospora rhodorangea elaborates a product having substantial antibacterial activity, said activity being due primarily to a novel antibiotic herein designated Antibiotic G-418. The disclosure sets forth methods for producing, isolating and using said antibiotic.
    Type: Grant
    Filed: October 10, 1975
    Date of Patent: December 14, 1976
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Raymond T. Testa, Joseph A. Marquez
  • Antibiotics sisomicin and verdamicin I and complex containing same
    Patent number: 3988316
    Abstract: A novel composition having antibiotic activity is produced by fermentation of the new species of microorganism, Micromonospora grisea. The antibiotic complex is composed of four components, Verdamicin I, sisomicin, Antibiotic G-418, and gentamicin A, of which Verdamicin I is a novel basic antibiotic possessing a broad antibacterial spectrum. The other components have been produced previously.
    Type: Grant
    Filed: February 18, 1975
    Date of Patent: October 26, 1976
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Joseph A. Marquez
  • Antibiotic G-418 and the production thereof
    Patent number: 3959254
    Abstract: A novel actinomycete herein designated Micromonospora rhodorangea elaborates a product having substantial antibacterial activity, said activity being due primarily to a novel antibiotic herein designated Antibiotic G-418. The disclosure sets forth methods for producing, isolating and using said antibiotic.
    Type: Grant
    Filed: November 8, 1973
    Date of Patent: May 25, 1976
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Raymond T. Testa, Joseph A. Marquez
  • Antibiotic G-52 and method for the production thereof
    Patent number: 3956068
    Abstract: A novel actinomycete herein designated Micromonospora zionensis elaborates a product having substantial antibacterial activity, said activity being due to sisomicin and the novel antibiotic substance coproduced therewith. The disclosure sets forth methods for producing, isolating and using the antibiotics.
    Type: Grant
    Filed: February 28, 1975
    Date of Patent: May 11, 1976
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Joseph A. Marquez
  • Actinomycin complex from micromonospora
    Patent number: 3954970
    Abstract: An antibiotic complex consisting of about 25 components herein designated antibiotic 70591 complex is produced by Micromonospora floridensis, a novel microorganism. The antibiotic complex has been classified as an actinomycin and has been found to exhibit a broad spectrum of antibacterial activity.
    Type: Grant
    Filed: May 24, 1974
    Date of Patent: May 4, 1976
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Joseph A. Marquez, Paul D. Watkins
  • Antibiotics and process for their manufacture
    Patent number: 3951746
    Abstract: A novel composition having antibiotic activity is produced by fermentation of the new species of microorganism, Micromonospora grisea. The antibiotic complex is composed of four components, Verdamicin I, sisomicin, Antibiotic G-418, and gentamicin A, of which Verdamicin I is a novel basic antibiotic possessing a broad antibacterial spectrum. The other components have been produced previously.
    Type: Grant
    Filed: February 18, 1975
    Date of Patent: April 20, 1976
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Joseph A. Marquez