Patents by Inventor Gerald J. Allen

Gerald J. Allen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of assay normalized with non-antigen calibrator
    Patent number: 5312729
    Abstract: The present invention relates to assay techniques for detection of ligands in solution and to means for putting such techniques into effect. In particular it relates to an improved assay technique which provides a liquid calibrator for use in standard assays in circumstances where the ligand itself is rare, expensive, or difficult to prepare in a sufficiently pure or quantifiable form.
    Type: Grant
    Filed: March 6, 1990
    Date of Patent: May 17, 1994
    Assignee: Ares-Serono Research & Development Limited Partnership
    Inventors: Gerald J. Allen, Madlyn D. Denyer, Grenville A. Robinson
  • Simultaneous immunoassay of two analytes using dual enzyme labelled antibodies
    Patent number: 5108896
    Abstract: The present invention relates to dual analyte enzyme immunoassays for assaying two antigens in a single liquid sample wherein the two immunoreactions are carried out simultaneously and wherein subsequently the two enzyme reactions occur simultaneously. Suitable enzyme/substrate pairs are beta-galactosidase/nitrophenyl-beta-D-galactoside (p- an/or o-) and alkaline phosphatase/phenolphthalein monophosphate.
    Type: Grant
    Filed: March 2, 1987
    Date of Patent: April 28, 1992
    Assignee: Applied Research Systems ARS Holding N.V.
    Inventors: Roger D. Philo, Gerald J. Allen
  • Double-labeled enzymeimmunoassay methods
    Patent number: 4808521
    Abstract: The present invention provides a method of performing an immunoassay of a ligand in a liquid sample wherein two independently measureable enzyme labels are separately conjugated to two or more components or populations of components of the assay system and, after completion of the complexing reaction, substantially all of the first enzyme label and a proportion of the second enzyme label are removed from the assay mixture, the proportion of the second label removed being related to the amount of the said ligand and the assay determined from a measurement of said proportion of the second label being normalised by comparison with a measurement of the total first label removed.In this way, manual pipetting errors and other assay procedural errors can be corrected for.
    Type: Grant
    Filed: January 22, 1986
    Date of Patent: February 28, 1989
    Assignee: Serone Diagnostics Partners
    Inventor: Gerald J. Allen
  • Immunoassay with chromatographic medium and labelled reagent
    Patent number: 4666863
    Abstract: A method of performing an assay for an analyte comprises providing a chromatographic medium, preferably in sheet form, forming a reaction mixture containing a labelled reagent present partly in a form which is mobile on the medium and partly in a form which is immobile, the proportions of the two forms being related to the analyte concentration, applying the mixture to a spot on the chromatographic medium, optionally applying a solvent to cause the mobile form of the labelled reagent to migrate from the spot, and measuring the label intensity remaining at the spot. The method provides a convenient way of performing immunoassays, 2-site immunometric assays, and agglutination assays.
    Type: Grant
    Filed: February 22, 1984
    Date of Patent: May 19, 1987
    Assignee: Amersham International plc.
    Inventors: John C. Edwards, Gerald J. Allen, John K. Martin, Malcolm R. Summers