Patents by Inventor Gerald L. Klein
Gerald L. Klein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7226562Abstract: The present invention provides an apparatus and method for storing a particle-containing liquid. The storage apparatus comprises a microfluidic convoluted flow channel having a plurality of particle capture regions. The storage channel is preferably an isotropic spatially periodic channel. Sedimented particles can be resuspended following storage. This invention further provides a microfluidic analysis cartridge having a convoluted storage channel therein. The sample analysis can use optical, electrical, pressure sensitive, or flow sensitive detection. A plurality of analysis channels can be included in a single cartridge. The analysis channels can be joined to reagent inlets for diluents, indicators or lysing agents. A mixing channel can be positioned between the reagent inlet and the analysis region to allow mixing and reaction of the reagent. The cartridge can include additional valves and pumps for flow management.Type: GrantFiled: August 2, 2005Date of Patent: June 5, 2007Assignee: University of WashingtonInventors: Mark R Holl, Floyd Edwards, Robert J Morff, Gerald L Klein
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Patent number: 6852284Abstract: The present invention provides an apparatus and method for storing a particle-containing liquid. The storage apparatus comprises a microfluidic convoluted flow channel having a plurality of article capture regions. The storage channel is preferably an isotropic spatially periodic channel. Sedimented particles can be resuspended following storage. This invention further provides a microfluidic analysis cartridge having a convoluted storage channel therein. The sample analysis can use optical, electrical, pressure sensitive, or flow sensitive detection. A plurality of analysis channels can be included in a single cartridge. The analysis channels can be joined to reagent inlets for diluents, indicators or lysing agents. A mixing channel can be positioned between the reagent inlet and the analysis region to allow mixing and reaction of the reagent. The cartridge can include additional valves and pumps for flow management.Type: GrantFiled: October 13, 2000Date of Patent: February 8, 2005Assignee: University of WashingtonInventors: Mark R. Holl, Floyd Edwards, Robert J. Morff, Gerald L. Klein
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Patent number: 6830729Abstract: The present invention provides an apparatus and method for storing a particle-containing liquid. The storage apparatus comprises a microfluidic convoluted flow channel having a plurality of particle capture regions. The storage channel is preferably an isotropic spatially periodic channel. Sedimented particles can be resuspended following storage. This invention further provides a microfluidic analysis cartridge having a convoluted storage channel therein. The sample analysis can use optical, electrical, pressure sensitive, or flow sensitive detection. A plurality of analysis channels can be included in a single cartridge. The analysis channels can be joined to reagent inlets for diluents, indicators or lysing agents. A mixing channel can be positioned between the reagent inlet and the analysis region to allow mixing and reaction of the reagent. The cartridge can include additional valves and pumps for flow management.Type: GrantFiled: November 28, 2000Date of Patent: December 14, 2004Assignee: University of WashingtonInventors: Mark R. Holl, Floyd Edwards, Robert Morff, Gerald L. Klein
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Patent number: 6712925Abstract: The present invention provides an apparatus and method for storing a particle-containing liquid. The storage apparatus comprises a microfluidic convoluted flow channel having a plurality of particle capture regions. The storage channel is preferably an isotropic spatially periodic channel. Sedimented particles can be resuspended following storage. This invention further provides a microfluidic analysis cartridge having a convoluted storage channel therein. The sample analysis can use optical, electrical, pressure sensitive, or flow sensitive detection. A plurality of analysis channels can be included in a single cartridge. The analysis channels can be joined to reagent inlets for diluents, indicators or lysing agents. A mixing channel can be positioned between the reagent inlet and the analysis region to allow mixing and reaction of the reagent. The cartridge can include additional valves and pumps for flow management.Type: GrantFiled: October 28, 1999Date of Patent: March 30, 2004Assignee: University of WashingtonInventors: Mark R. Holl, Floyd Edwards, Robert Morff, Gerald L. Klein
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Patent number: 6656431Abstract: The present invention provides an apparatus and method for storing a particle-containing liquid. The storage apparatus comprises a microfluidic convoluted flow channel having a plurality of particle capture regions. The storage channel is preferably an isotropic spatially periodic channel. Sedimented particles can be resuspended following storage. This invention further provides a microfluidic analysis cartridge having a convoluted storage channel therein. The sample analysis can use optical, electrical, pressure sensitive, or flow sensitive detection. A plurality of analysis channels can be included in a single cartridge. The analysis channels can be joined to reagent inlets for diluents, indicators or lysing agents. A mixing channel can be positioned between the reagent inlet and the analysis region to allow mixing and reaction of the reagent. The cartridge can include additional valves and pumps for flow management.Type: GrantFiled: October 28, 1999Date of Patent: December 2, 2003Assignee: University of WashingtonInventors: Mark R. Holl, Floyd Edwards, Robert Morff, Gerald L. Klein
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Publication number: 20030212078Abstract: A pharmacological composition includes an anti-histaminic in spray formulation that reduces symptomatic skin itching of skin without substantially eliciting weight gain or sedation in the patient when the composition is sprayed onto the area of skin at a dosage of at least 10 mg/ml over a period of at least 10 applications. Particularly contemplated anti-histaminic include hydroxyzine and ketotifen.Type: ApplicationFiled: March 26, 2003Publication date: November 13, 2003Inventor: Gerald L. Klein
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Publication number: 20030152487Abstract: The present invention provides an apparatus and method for storing a particle-containing liquid. The storage apparatus comprises a microfluidic convoluted flow channel having a plurality of particle capture regions. The storage channel is preferably an isotropic spatially periodic channel. Sedimented particles can be resuspended following storage. This invention further provides a microfluidic analysis cartridge having a convoluted storage channel therein. The sample analysis can use optical, electrical, pressure sensitive, or flow sensitive detection. A plurality of analysis channels can be included in a single cartridge. The analysis channels can be joined to reagent inlets for diluents, indicators or lysing agents. A mixing channel can be positioned between the reagent inlet and the analysis region to allow mixing and reaction of the reagent. The cartridge can include additional valves and pumps for flow management.Type: ApplicationFiled: October 28, 1999Publication date: August 14, 2003Inventors: MARK R. HOLL, FLOYD EDWARDS, ROBERT J. MORFF, GERALD L. KLEIN
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Patent number: 6576194Abstract: The present invention provides an apparatus and method for storing a particle-containing liquid. The storage apparatus comprises a microfluidic convoluted flow channel having a plurality of particle capture regions. The storage channel is preferably an isotropic spatially periodic channel. Sedimented particles can be resuspended following storage. This invention further provides a microfluidic analysis cartridge having a convoluted storage channel therein. The sample analysis can use optical, electrical, pressure sensitive, or flow sensitive detection. A plurality of analysis channels can be included in a single cartridge. The analysis channels can be joined to reagent inlets for diluents, indicators or lysing agents. A mixing channel can be positioned between the reagent inlet and the analysis region to allow mixing and reaction of the reagent. The cartridge can include additional valves and pumps for flow management.Type: GrantFiled: October 28, 1999Date of Patent: June 10, 2003Assignee: University of WashingtonInventors: Mark R. Holl, Floyd Edwards, Robert J. Morff, Gerald L. Klein
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Publication number: 20030096430Abstract: The present invention provides an apparatus and method for storing a particle-containing liquid. The storage apparatus comprises a microfluidic convoluted flow channel having a plurality of particle capture regions. The storage channel is preferably an isotropic spatially periodic channel. Sedimented particles can be resuspended following storage. This invention further provides a microfluidic analysis cartridge having a convoluted storage channel therein. The sample analysis can use optical, electrical, pressure sensitive, or flow sensitive detection. A plurality of analysis channels can be included in a single cartridge. The analysis channels can be joined to reagent inlets for diluents, indicators or lysing agents. A mixing channel can be positioned between the reagent inlet and the analysis region to allow mixing and reaction of the reagent. The cartridge can include additional valves and pumps for flow management.Type: ApplicationFiled: October 28, 1999Publication date: May 22, 2003Inventors: MARK R. HOLL, FLOYD EDWARDS, ROBERT J. MORFF, GERALD L. KLEIN
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Patent number: 6557427Abstract: A capillary for introduction of whole blood into an analysis device. The capillary has a variable volume along its length, which allows the liquid sample to be drawn into the interior of the cartridge, away from the inlet, reducing the risk of contamination of the sample from the outside.Type: GrantFiled: May 23, 2001Date of Patent: May 6, 2003Assignee: Micronics, Inc.Inventors: Bernhard H. Weigl, Gerald L. Klein, Ronald L. Bardell, C. Frederick Battrell
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Patent number: 6537501Abstract: The present invention provides an apparatus and method for storing a particle-containing liquid. The storage apparatus comprises a microfluidic convoluted flow channel having a plurality of particle capture regions. The storage channel is preferably an isotropic spatially periodic channel. Sedimented particles can be resuspended following storage. This invention further provides a microfluidic analysis cartridge having a convoluted storage channel therein. The sample analysis can use optical, electrical, pressure sensitive, or flow sensitive detection. A plurality of analysis channels can be included in a single cartridge. The analysis channels can be joined to reagent inlets for diluents, indicators or lysing agents. A mixing channel can be positioned between the reagent inlet and the analysis region to allow mixing and reaction of the reagent. The cartridge can include additional valves and pumps for flow management.Type: GrantFiled: October 28, 1999Date of Patent: March 25, 2003Assignee: University of WashingtonInventors: Mark R. Holl, Floyd Edwards, Robert J. Morff, Gerald L. Klein
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Patent number: 6488896Abstract: A device for analyzing sample solutions such as whole blood based on coagulation and agglutination which requires no external power source or moving parts to perform the analysis. Single disposable cartridges for performing blood typing assays can be constructed using this technology.Type: GrantFiled: March 13, 2001Date of Patent: December 3, 2002Assignee: Micronics, Inc.Inventors: Bernhard H. Weigl, Gerald L. Klein, Ronald L. Bardell, Clinton L. Williams, Thomas H. Schulte
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Publication number: 20020160518Abstract: A device for promoting sedimentation within microfluidic channels which uses gravity to separate particles from fluid. Particles such as blood cells or beads are separated from a carrier fluid using gravity combined with various devices such as membranes and sonic energy in different embodiments.Type: ApplicationFiled: April 3, 2002Publication date: October 31, 2002Inventors: Jon W. Hayenga, C. Frederick Battrell, Bernhard H. Weigl, Christopher J. Morris, Patrick Saltsman, Gerald L. Klein
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Publication number: 20020025279Abstract: A capillary for introduction of whole blood into an analysis device. The capillary has a variable volume along its length, which allows the liquid sample to be drawn into the interior of the cartridge, away from the inlet, reducing the risk of contamination of the sample from the outside.Type: ApplicationFiled: May 23, 2001Publication date: February 28, 2002Inventors: Bernhard H. Weigl, Gerald L. Klein, Ronald L. Bardell, C. Frederick Battrell
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Publication number: 20020003001Abstract: A passive valve for use within microfluidic structures. Surface tension forces developed within microscale channels are used to control flow within the channels. Flow can be halted within a channel until fluid force reaches a predetermined pressure to allow the channel to open.Type: ApplicationFiled: May 23, 2001Publication date: January 10, 2002Inventors: Bernhard H. Weigl, Gerald L. Klein
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Publication number: 20010048900Abstract: A device for mixing separate distinct fluids within a microfluidic device to form a substantially homogeneous flow stream. The device is generally circular-shaped and contains no moving parts, and is capable of mixing both serial and laminar flow streams.Type: ApplicationFiled: May 23, 2001Publication date: December 6, 2001Inventors: Ronald L. Bardell, Gerald L. Klein
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Publication number: 20010046453Abstract: A device for analyzing sample solutions such as whole blood based on coagulation and agglutination which requires no external power source or moving parts to perform the analysis.Type: ApplicationFiled: March 13, 2001Publication date: November 29, 2001Inventors: Bernhard H. Weigl, Gerald L. Klein, Ronald L. Bardell, Clinton L. Williams, Thomas H. Schulte
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Publication number: 20010042712Abstract: A device for generating a stable concentration gradient in a microfluidic channel. A solution of a given concentration of a soluble compound and a diluting solution are co-delivered into a microfluidic channel. By varying the flow rates of the two solutions, the concentration of the soluble compound can be varied as a function of the length of the channel.Type: ApplicationFiled: May 23, 2001Publication date: November 22, 2001Inventors: C. Frederick Battrell, Ronald L. Bardell, Gerald L. Klein
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Patent number: 5963456Abstract: A method and apparatus for displaying capillary electrophoresis data wherein absorbance with respect to time is related to graphic values within a graphic range or scale of values and selected graphic values are displayed with respect to time. The selected graphic values may comprise a range hues, color saturation and/or brightness or may represent a monochromatic scale. The resulting representation may be horizontally aligned with the corresponding electrophoretogram absorbance values to provide both a quantitative value (electrophoretogram absorbance values) and qualitative (graphic stripe) display.Type: GrantFiled: November 27, 1996Date of Patent: October 5, 1999Assignee: Beckman Instruments, Inc.Inventors: Gerald L. Klein, Steven P. Katzmann
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Patent number: 5449621Abstract: An automated patient sample analysis instrument uses assay cartridges which are pre-loaded with all reactants needed to perform an assay. Photometric measurements are performed on the cartridges while spinning at variable speeds in a centrifuge. Both axial and transverse measurements can be made on the cartridges. Multiple optical channels can be read by single detector. The instrument is well suited for low volume and for use by unskilled individuals. The photometric measurements are made by dividing the width of a measurement window into n intervals, measuring an optical result in one of the n intervals in each of n rotations of the cartridge, repeating the measurement process x times, summing or averaging the x results for each of the n intervals and selecting y of the largest resultant averaged or summed measurements as representative of the maximum measurement for the window.Type: GrantFiled: January 21, 1994Date of Patent: September 12, 1995Assignee: Biotope, Inc.Inventor: Gerald L. Klein