Patents by Inventor Gerald Lewis Kaplan

Gerald Lewis Kaplan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 4-dimethylaminobutyric acid derivatives
    Patent number: 8344027
    Abstract: This invention relates to novel 4-dimethylaminobutyric acid derivatives of the formula wherein A1, A2, R1, m and n are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds inhibit carnitine palmitoyl transferase (CPT) activity, in particular CPT2 activity, and can be used as medicaments in methods for the treatment of diseases modulated by CPT2 inhibitors.
    Type: Grant
    Filed: April 28, 2009
    Date of Patent: January 1, 2013
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Mirjana Andjelkovic, Simona M. Ceccarelli, Odile Chomienne, Gerald Lewis Kaplan, Patrizio Mattei, Jefferson Wright Tilley
  • 4-DIMETHYLAMINOBUTYRIC ACID DERIVATIVES
    Publication number: 20120289554
    Abstract: This invention relates to novel 4-dimethylaminobutyric acid derivatives of the formula wherein A1, A2, R1, m and n are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds inhibit carnitine palmitoyl transferase (CPT) activity, in particular CPT2 activity, and can be used as medicaments in methods for the treatment of diseases modulated by CPT2 inhibitors.
    Type: Application
    Filed: July 24, 2012
    Publication date: November 15, 2012
    Inventors: Mirjana Andjelkovic, Simona M. Ceccarelli, Odile Chomienne, Gerald Lewis Kaplan, Patrizio Mattei, Jefferson Wright Tilley
  • 4-DIMETHYLAMINOBUTYRIC ACID DERIVATIVES
    Publication number: 20090270505
    Abstract: This invention relates to novel 4-dimethylaminobutyric acid derivatives of the formula wherein A1, A2, R1, m and n are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds inhibit carnitine palmitoyl transferase (CPT) activity, in particular CPT2 activity, and can be used as medicaments in methods for the treatment of diseases modulated by CPT2 inhibitors.
    Type: Application
    Filed: April 28, 2009
    Publication date: October 29, 2009
    Inventors: Mirjana Andjelkovic, Simona M. Ceccarelli, Odile Chomienne, Gerald Lewis Kaplan, Patrizio Mattei, Jefferson Wright Tilley
  • 4-pyridinyl-n-acyl-l-phenylalanines
    Patent number: 6916933
    Abstract: Compounds of Formula I have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4 and are useful for treating disease whose symptoms and or damage are related to the binding of VCAM-1 to cells expressing VLA-4.
    Type: Grant
    Filed: September 24, 2003
    Date of Patent: July 12, 2005
    Assignee: Hoffman-La Roche Inc.
    Inventors: Gerald Lewis Kaplan, Achyutharao Sidduri, Jefferson Wright Tilley
  • 4-Pyridinyl-n-acyl-l-phenylalanines
    Publication number: 20040127706
    Abstract: Compounds of Formula I have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4 and are useful for treating disease whose symptoms and or damage are related to the binding of VCAM-1 to cells expressing VLA-4.
    Type: Application
    Filed: September 24, 2003
    Publication date: July 1, 2004
    Inventors: Gerald Lewis Kaplan, Achyutharao Sidduri, Jefferson Wright Tilley
  • 4-pyridinyl-N-acyl-L-phenylalanines
    Publication number: 20020133015
    Abstract: Compounds of Formula I have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4 and are useful for treating disease whose symptoms and or damage are related to the binding of VCAM-1 to cells expressing VLA-4.
    Type: Application
    Filed: January 29, 2002
    Publication date: September 19, 2002
    Inventors: Gerald Lewis Kaplan, Achyutharao Sidduri, Jefferson Wright Tilley
  • 4-pyridinyl-n-acyl-l-phenylalanines
    Patent number: 6388084
    Abstract: Compounds of Formula I have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4 and are useful for treating disease whose symptoms and or damage are related to the binding of VCAM-1 to cells expressing VLA-4.
    Type: Grant
    Filed: November 21, 2000
    Date of Patent: May 14, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Gerald Lewis Kaplan, Achyutharao Sidduri, Jefferson Wright Tilley