Patents by Inventor Gerald Nepom

Gerald Nepom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IDENTIFICATION AND MEDICAL APPLICATIONS OF ANTI-CITRULLINATED-PROTEIN ANTIBODIES IN RHEUMATOID ARTHRITIS
    Publication number: 20250164481
    Abstract: Compositions and methods for detection of anti-citrullinated protein antibodies (ACPAs) in rheumatoid arthritis (RA) patients. Patient samples known or suspected of containing ACPAs were probed against citrullinated proteins, and antibody responses to 190 citrullinated proteins in 20 RA patients were investigated. Unique antibody reactivity patterns in both clinical anti-cyclic citrullinated peptide assay positive (CCP+) and negative (CCP?) RA patients were observed. At individual antigen levels, six novel antibody/antigen complexes were discovered and validated against specific citrullinated antigens (Myelin Basic Protein (MBP), osteopontin (SPP1), flap endonuclease (FEN1), insulin like growth factor binding protein 6 (IGFBP6), insulin like growth factor I (IGF1) and stanniocalcin-2 (STC2)) in RA patients. Identification of immune-dominant epitope(s) for citrullinated MBP was also performed. The identified biomarkers have high specificity, especially MBP.
    Type: Application
    Filed: January 17, 2025
    Publication date: May 22, 2025
    Inventors: Joshua LaBaer, Ji Qiu, Kailash Karthikeyan, Jane Buckner, Gerald Nepom
  • Identification and medical applications of anti-citrullinated-protein antibodies in rheumatoid arthritis
    Patent number: 12235268
    Abstract: Compositions and methods for detection of anti-citrullinated protein antibodies (ACPAs) in rheumatoid arthritis (RA) patients. Patient samples known or suspected of containing ACPAs were probed against citrullinated proteins, and antibody responses to 190 citrullinated proteins in 20 RA patients were investigated. Unique antibody reactivity patterns in both clinical anti-cyclic citrullinated peptide assay positive (CCP+) and negative (CCP?) RA patients were observed. At individual antigen levels, six novel antibody/antigen complexes were discovered and validated against specific citrullinated antigens (Myelin Basic Protein (MBP), osteopontin (SPP1), flap endonuclease (FENI), insulin like growth factor binding protein 6 (IGFBP6), insulin like growth factor I (IGF1) and stanniocalcin-2 (STC2)) in RA patients. Identification of immune-dominant epitope(s) for citrullinated MBP was also performed. The identified biomarkers have high specificity, especially MBP.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: February 25, 2025
    Assignees: SCOTTSDALEARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY, BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON
    Inventors: Joshua LaBaer, Ji Qiu, Kailash Karthikeyan, Jane Buckner, Gerald Nepom
  • METHODS OF MHC CLASS II EPITOPE MAPPING, DETECTION OF AUTOIMMUNE T CELLS AND ANTIGENS, AND AUTOIMMUNE TREATMENT
    Publication number: 20090226471
    Abstract: The present invention provides of using multimeric MHC class II/peptide complexes. In one aspect, methods provided for identifying MHC class II-restricted immune epitopes of a predetermined polypeptide antigen. Methods for identifying an immunostimulatory epitope for a predetermined polypeptide antigen are provided. In a related aspect, methods for screening a therapeutic polypeptide agent for an MHC class II epitope are provided. In other aspects, methods for modulating T cells and for determining or monitoring an MHC class II-restricted immune status of a patient are also provided.
    Type: Application
    Filed: February 20, 2009
    Publication date: September 10, 2009
    Applicant: BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON
    Inventors: WILLIAM W. KWOK, GERALD NEPOM, JOHN GEBE, HELENA REIJONEN, ANDREW LIU
  • Methods of MHC class II epitope mapping, detection of autoimmune T cells and antigens, and autoimmune treatment
    Publication number: 20060240482
    Abstract: The present invention provides of using multimeric MHC class II/peptide complexes. In one aspect, methods provided for identifying MHC class II-restricted immune epitopes of a predetermined polypeptide antigen. Methods for identifying an immunostimulatory epitope for a predetermined polypeptide antigen are provided. In a related aspect, methods for screening a therapeutic polypeptide agent for an MHC class II epitope are provided. In other aspects, methods for modulating T cells and for determining or monitoring an MHC class II-restricted immune status of a patient are also provided.
    Type: Application
    Filed: June 22, 2006
    Publication date: October 26, 2006
    Applicant: Benaroya Research Institute at Virginia Mason
    Inventors: William Kwok, Gerald Nepom, John Gebe, Helena Reijonen, Andrew Liu
  • Methods of MHC class II epitope mapping, detection of autoimmune T cells and antigens, and autoimmune treatment
    Patent number: 7094555
    Abstract: The present invention provides of using multimeric MHC class II/peptide complexes. In one aspect, methods provided for identifying MHC class II-restricted immune epitopes of a predetermined polypeptide antigen. Methods for identifying an immunostimulatory epitope for a predetermined polypeptide antigen are provided. In a related aspect, methods for screening a therapeutic polypeptide agent for an MHC class II epitope are provided. In other aspects, methods for modulating T cells and for determining or monitoring an MHC class II-restricted immune status of a patient are also provided.
    Type: Grant
    Filed: April 5, 2002
    Date of Patent: August 22, 2006
    Assignee: Benaroya Research Institute at Virginia Mason
    Inventors: William W. Kwok, Gerald Nepom, John Gebe, Helena Reijonen, Andrew Liu
  • Methods of MHC class II epitope mapping, detection of autoimmune T cells and antigens, and autoimmune treatment
    Publication number: 20030073102
    Abstract: The present invention provides of using multimeric MHC class II/peptide complexes. In one aspect, methods provided for identifying MHC class II-restricted immune epitopes of a predetermined polypeptide antigen. Methods for identifying an immunostimulatory epitope for a predetermined polypeptide antigen are provided. In a related aspect, methods for screening a therapeutic polypeptide agent for an MHC class II epitope are provided. In other aspects, methods for modulating T cells and for determining or monitoring an MHC class II-restricted immune status of a patient are also provided.
    Type: Application
    Filed: April 5, 2002
    Publication date: April 17, 2003
    Applicant: Virginia Mason Research Center
    Inventors: William W. Kwok, Gerald Nepom, John Gebe, Helena Reijonen, Andrew Liu