Abstract: The present invention is concerned with novel compositions and vaccines useful for prophylactic an/or therapeutic treatment of mucosal infections, and in particular it is concerned with oral vaccines and with methods of enhancing mucosal resistance to infection or for treating established infections, of the respiratory tract.

Abstract: There is described a method for selecting microbial isolates for use in oral killed vaccines against abnormal microbial colonization of mucosal surfaces by the microbes. The method comprises evaluating capacity of a plurality of different isolates of a microbe to activate antigen responsive cells to provide activation data for each microbial isolate, and the effectiveness of the isolates in reducing infection of a mucosal surface by the microbe to provide clearance data for each microbial isolate. An isolate, the activation data and clearance data for which correlate and is optimal for generating mucosal immunity against the microbe compared to the, or each, other of the isolates, or an isolate the activation data for which is optimal and a further isolate the clearance data for which is optimal, compared to the, or each, other of the isolates, respectively, is then selected for use in the vaccine.

Abstract: A system and method for estimating needed medical supplies based on a selected predefined operational scenario. A predefined operational scenario may be modified, a new operational scenario may be built, or a predefined operational scenario may be imported from an external source. A computer-readable program, system and method is provided for enabling a user to produce a query concerning relationships between patient conditions, tasks and medical supplies needed in specific locations. The production of a report or query is performed by referencing a database containing data pertaining to patient conditions, functional locations at which patients are to be treated (triage, operating room, etc.), equipment available in defined functional areas, tasks associated with treatment of defined patient conditions, medical supplies needed to carry out each defined task, and relationships therebetween, and determining needed medical supplies based on use data input and data contained in the database.

Abstract: The present invention relates to novel oral compositions and vaccines, and in particular to oral vaccines for the prevention or therapy of candidiasis.

Abstract: There is described a method for selecting microbial isolates for use in oral killed vaccines against abnormal microbial colonisation of mucosal surfaces by the microbes. The method comprises evaluating capacity of a plurality of different isolates of a microbe to activate antigen responsive cells to provide activation data for each microbial isolate, and the effectiveness of the isolates in reducing infection of a mucosal surface by the microbe to provide clearance data for each microbial isolate. An isolate, the activation data and clearance data for which correlate and is optimal for generating mucosal immunity against the microbe compared to the, or each, other of the isolates, or an isolate the activation data for which is optimal and a further isolate the clearance data for which is optimal, compared to the, or each, other of the isolates, respectively, is then selected for use in the vaccine.

Abstract: There is disclosed a method for determining an administration regimen for an oral killed vaccine for use in immunising individuals in a population against an infection or disease. The method comprise administering the oral killed vaccine to one or more individuals in a population and identifying an indicative dosaging level of the vaccine which induces a reduction in immune system responsiveness to the vaccine in the one or more individuals. A further dosaging level that elicits an immune response in one or more individuals of the population without inducing the reduction in immune system responsiveness to the vaccine is then determined.

Abstract: The present invention relates to methods of predicting the risk of developing cancer and in particular to a method for diagnosing, and/or predicting the risk of developing gastric cancer in a subject infected with Helicobacter.

Abstract: The present invention relates to methods of identifying potentially therapeutic compounds for the treatment of hepatic disorders, preferably alcohol-induced hepatitis. Further, use of mammals in such methods, therapeutic compounds identified using said methods and the use of a Chinese Herb, CH-100, in the treatment of hepatic disorders, particularly alcohol-induced hepatic disorders, are described.

Abstract: The present invention relates to methods of identifying potentially therapeutic compounds for the treatment of hepatic disorders, preferably alcohol-induced hepatitis. Further, use of mammals in such methods, therapeutic compounds identified using said methods and the use of a Chinese Herb, CH-100, in the treatment of hepatic disorders, particularly alcohol-induced hepatic disorders, are described.

Abstract: The present invention relates to methods for diagnosis, prevention and treatment of cardiovascular disorders or associated disorders and, in particular, to the use in such methods of regulating cytokine levels or activity. Compositions and kits suitable for use in the methods are described.

Abstract: The present invention relates to methods of predicting the risk of developing cancer and in particular to a method for diagnosing, and/or predicting the risk of developing gastric cancer in a subject infected with Helicobacter.

Abstract: There is disclosed a method of prophylactic or therapeutic treatment of a cardiovascular disorder comprising administering to a subject in need thereof an effective amount of one or more agents for upregulating a cytokine profile characteristic of a Th1 T-cell response relative to a cytosine profile of a Th2 T-cell response associated with the disorder. There is further disclosed compositions for use in the methods.

Abstract: The present invention is concerned with methods of assessing performance and performance potential in horses using measurement of immunoglobulin levels, particularly levels of IgA and/or IgG. The invention is also concerned with methods for predicting impaired performance, fatigue and/or susceptibility to infection in horses exposed to stressors, in particular physical stressors.

Abstract: The present invention is concerned with novel compositions and vaccines useful for prophylactic an/or therapeutic treatment of mucosal infections, and in particular it is concerned with oral vaccines and with methods of enhancing mucosal resistance to infection or for treating established infections, of the respiratory tract.

Abstract: The invention relates to methods of preventing and treating endotoxemia and related disorders. In particular, the invention relates to methods of preventing and treating endotoxemia and related disorders using a probiotic. The invention also relates to methods for assessing the efficacy ot a probiotic in the prevention and treatment of endotoxemia and related disorders.

Abstract: The present invention relates to novel oral compositions and vaccines, and in particular to oral vaccines for the prevention or therapy of candidiasis.

Abstract: Compositions and methods for therapeutic or prophylactic treatment of disorders associated with mucosal surfaces and in particular to treatment of infectious disorders at mucosal sites by enhancing non-specific mucosal immunity, especially with probiotics such as lactobacillus or mycobacterium vaccae.