Abstract: Described herein are methods useful for the treatment of cancers in a canine subject with a pharmaceutical compositions comprising HDAC inhibitors, Rapamycin, Dasatinib, Lapatinib, Trametinib, Vorinostat, Imatinib, Crizotinib, Sorafenib, and combinations thereof. Also described herein are methods for identification of subjects with cancers that will benefit from administration of the pharmaceutical compositions comprising HIDAC inhibitors, Rapamycin, Dasatinib, Lapatinib, Trametinib, Vorinostat, Imatinib, Crizotinib, Sorafenib, and combinations thereof. In certain aspects, the methods described herein further comprise administering a therapeutically effective amount of at least one additional anti-cancer agent.

Abstract: Described herein are methods useful for the treatment of cancers in a canine subject with a pharmaceutical compositions comprising HD AC inhibitors, Rapamycin, Dasatinib, Lapatinib, Trametinib, Vorinostat, Imatinib, Crizotinib, Sorafenib, and combinations thereof. Also described herein are methods for identification of subjects with cancers that will benefit from administration of the pharmaceutical compositions comprising HD AC inhibitors, Rapamycin, Dasatinib, Lapatinib, Trametinib, Vorinostat, Imatinib, Crizotinib, Sorafenib, and combinations thereof. In certain aspects, the methods described herein further comprise administering a therapeutically effective amount of at least one additional anti-cancer agent.

Abstract: Described herein are methods useful for the treatment of cancers in a canine subject with a pharmaceutical compositions comprising HDAC inhibitors, Rapamycin, Dasatinib, Lapatinib, Trametinib, Vorinostat, Imatinib, Crizotinib, Sorafenib, and combinations thereof. Also described herein are methods for identification of subjects with cancers that will benefit from administration of the pharmaceutical compositions comprising HDAC inhibitors, Rapamycin, Dasatinib, Lapatinib, Trametinib, Vorinostat, Imatinib, Crizotinib, Sorafenib, and combinations thereof. In certain aspects, the methods described herein further comprise administering a therapeutically effective amount of at least one additional anti-cancer agent.

Abstract: Described herein are methods useful for the treatment of cancers in a canine subject with a pharmaceutical compositions comprising HDAC inhibitors, Rapamycin, Dasatinib, Lapatinib, Trametinib, Vorinostat, Imatinib, Crizotinib, Sorafenib, and combinations thereof. Also described herein are methods for identification of subjects with cancers that will benefit from administration of the pharmaceutical compositions comprising HDAC inhibitors, Rapamycin, Dasatinib, Lapatinib, Trametinib, Vorinostat, Imatinib, Crizotinib, Sorafenib, and combinations thereof. In certain aspects, the methods described herein further comprise administering a therapeutically effective amount of at least one additional anti-cancer agent.

Abstract: Described herein are methods useful for the treatment of cancers in a canine subject with a pharmaceutical compositions comprising HD AC inhibitors, Rapamycin, Dasatinib, Lapatinib, Trametinib, Vorinostat, Imatinib, Crizotinib, Sorafenib, and combinations thereof. Also described herein are methods for identification of subjects with cancers that will benefit from administration of the pharmaceutical compositions comprising HD AC inhibitors, Rapamycin, Dasatinib, Lapatinib, Trametinib, Vorinostat, Imatinib, Crizotinib, Sorafenib, and combinations thereof. In certain aspects, the methods described herein further comprise administering a therapeutically effective amount of at least one additional anti-cancer agent.

Abstract: A method for heating an interior of a motor vehicle having a fuel cell, a climate measuring device by which a climate parameter of the interior of the motor vehicle is measured, and a heat transfer device for transferring heat that is generated by the fuel cell to the interior of the motor vehicle. At least one operating parameter of the fuel cell is set also as a function of the climate parameter of the interior of the motor vehicle so that the rate of the heat that is generated by the fuel cell depends on the operating parameter.

Abstract: A method for shutting down a fuel cell system having at least one fuel cell, especially a fuel cell provided with a proton exchanging membrane, anode and cathode inlets, anode and cathode outlets, an anode recirculation circuit, a device which is operated according to the Venturi principle and is used to convey the gas in the anode recirculation circuit, and a hydrogen and air supply is disclosed. A method characterized by low emission values and high efficiency is provided. The hydrogen supply to the anode is interrupted during shutdown of the fuel cell system and the current generated from the residual hydrogen is supplied to an electric consumer.

Abstract: In a method and apparatus for wetting a fuel cell unit on the basis of a predetermined dew point nominal value as a function of the operating state of the fuel cell unit, a corrected dew point nominal value is determined using a predetermined dew point nominal value, a component-specific correction value, and a process correction value. The corrected dew point nominal value is used to set the required amount of water for optimum wetting of the fuel cell unit.

Abstract: A fuel cell system is provided having at least one switching means (16, 17, 18) for reversing the direction of a flow of at least one working medium in a fuel cell unit (10), with the fuel cell unit (10) having a cathode (11), an anode (12) and a cooling water device (13) in a housing (26). Advantageously more reliable operation with less component complexity is made possible by the switching means (16, 17, 18) being arranged outside the housing (26).

Abstract: A method sculpturing from sheet material a vacuum formed glass mold. The sheet material is cut into a plurality of sections that are combined into laminated structure is that is welded together and mounted on a mold base. The top surfaces of the individual sections are machined to form a glass forming surface that can be used to vacuum form glass that conforms to the shape of the forming surface.

Abstract: An apparatus sculpturing from sheet material a vacuum formed glass mold. The sheet material is cut into a plurality of sections that are combined into laminated structure is that is welded together and mounted on a mold base. The top surfaces of the individual sections are machined to form a glass forming surface that can be used to vacuum form glass that conforms to the shape of the forming surface.