Patents by Inventor Gerald R. Kovacs

Gerald R. Kovacs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Packaging of positive-strand RNA virus replicon particles
    Patent number: 7034141
    Abstract: The invention generally relates to recombinant polynucleotides, positive-strand RNA virus (psRNAV) recombinant expression vectors, and packaging systems. The packaging systems are based on the expression of helper functions by coinfecting recombinant poxvirus vectors comprising recombinant polynucleotides. Methods for obtaining psRNAV replicon particles using these packaging systems are disclosed. Immunogenic compositions and pharmaceutical formulations are provided that comprise replicon particles of the invention. Methods for generating an immune response or producing a pharmaceutical effect are also provided.
    Type: Grant
    Filed: August 28, 2001
    Date of Patent: April 25, 2006
    Assignee: Wyeth Holdings Corporation
    Inventors: Gerald R. Kovacs, Nikos Vasilakis, Jacek Kowalski, Seema Gangolli, Timothy Zamb
  • Packaging of positive-strand rna virus replicon particles
    Publication number: 20040029279
    Abstract: The invention generally relates to recombinant polynucleotides, positive-strand RNA virus (psRNAV) recombinant expression vectors, and packaging systems. The packaging systems are based on the expression of helper functions by coinfecting re-combinant poxvirus vectors comprising recombinant polynucleotides. Methods for obtaining psRNAV replicon particles using these packaging systems are disclosed. Immunogenic compositions and pharmaceutical formulations are provided that comprise replicon particles of the invention. Methods for generating an immune response or producing a pharmaceutical effect are also provided.
    Type: Application
    Filed: August 27, 2003
    Publication date: February 12, 2004
    Inventors: Gerald R. Kovacs, Nikos Vasilakis, Jacek Kowalski, Seema Gangolli, Timothy Zamb
  • Methods for rescue of RNA viruses
    Patent number: 6673572
    Abstract: This invention relates to improved methods for producing nonsegmented, negative-sense, single-stranded RNA viruses of the Order designated Mononegavirales virus, including embodiments relating to methods of producing such viruses as attenuated and/or infectious viruses, such as Measles virus (MV) and respiratory syncytial virus (RSV).
    Type: Grant
    Filed: October 1, 2002
    Date of Patent: January 6, 2004
    Assignee: Wyeth Holdings Corporation
    Inventors: Christopher L. Parks, Mohinderjit S. Sidhu, Stephen A. Udem, Gerald R. Kovacs
  • Novel methods for rescue of RNA viruses
    Publication number: 20030129729
    Abstract: This invention relates to improved methods for producing nonsegmented, negative-sense, single-stranded RNA viruses of the Order designated Mononegavirales virus, including embodiments relating to methods of producing such viruses as attenuated and/or infectious viruses, such as Measles virus (MV) and respiratory syncytial virus (RSV).
    Type: Application
    Filed: October 1, 2002
    Publication date: July 10, 2003
    Applicant: Wyeth
    Inventors: Christopher L. Parks, Mohinderjit S. Sidhu, Stephen A. Udem, Gerald R. Kovacs