Abstract: Provided herein is a photonic integrated circuit and methods for controlling a photonic integrated circuit that can utilize the resonant frequency of one or more components of the photonic integrated circuit to enhance the response of the circuit. At least one component of the photonic integrated circuit can be driven by an electrical signal whose frequency is substantially equal to the mechanical resonance frequency of the component such that the response of the optical component is increased. The component of the photonic integrated circuit can include a phase shifter that can impart a phase shift on a received optical signal. By driving the phase shifter with an electrical signal that is equal to the mechanical resonance frequency of the optical phase shifter, less power can be required to impart a desired phase shift on a received optical signal. The optical components can be implemented using piezoelectric cantilevers.

Abstract: A system includes a first separator that separates water from a fluid material. The water settles on the bottom of the water knock-out tank. The system includes multiple compressors to boost the pressure of the fluid material. The system includes a second separator that separates condensate from the fluid material. The system includes a mixing pipe that mixes glycol with the fluid material and a first heat exchanger that cools the mixed fluid material and glycol. The system includes a third separator that separates gaseous components and liquid components of the mixed fluid material and glycol and a fourth separator that separates the liquid components of the mixed fluid material and glycol. The system includes a fractional distillation column that heats a first liquid from the fourth separator, gasifying a first portion of the first liquid. A second portion of the first liquid remains liquid and is natural gas liquids.

Abstract: A system for suspending an automobile using an air rear suspension is provided. The system may include an automobile having a body, a front axle, and a rear axle; a linkage bar connected to said body and to said rear axle, wherein said connections allow for relative movement between said body and said rear axle; a cantilever bar having a first cantilever end and a second cantilever end; a damper; and an air spring, wherein said cantilever bar is connected to each of said rear axle and said body at said first cantilever end, wherein said cantilever bar is connected to each of said damper and said air spring at said second cantilever end, wherein said damper and said air spring are each connected to said body, and wherein said linkage bar and said cantilever bar are each configured to move in response to movement of said rear axle relative to said body.

Abstract: A system for suspending an automobile using an air rear suspension is provided. The system may include an automobile having a body, a front axle, and a rear axle; a linkage bar connected to said body and to said rear axle, wherein said connections allow for relative movement between said body and said rear axle; a cantilever bar having a first cantilever end and a second cantilever end; a damper; and an air spring, wherein said cantilever bar is connected to each of said rear axle and said body at said first cantilever end, wherein said cantilever bar is connected to each of said damper and said air spring at said second cantilever end, wherein said damper and said air spring are each connected to said body, and wherein said linkage bar and said cantilever bar are each configured to move in response to movement of said rear axle relative to said body.

Abstract: A system includes a first separator that separates water from a fluid material. The water settles on the bottom of the water knock-out tank. The system includes multiple compressors to boost the pressure of the fluid material. The system includes a second separator that separates condensate from the fluid material. The system includes a mixing pipe that mixes glycol with the fluid material and a first heat exchanger that cools the mixed fluid material and glycol. The system includes a third separator that separates gaseous components and liquid components of the mixed fluid material and glycol and a fourth separator that separates the liquid components of the mixed fluid material and glycol. The system includes a fractional distillation column that heats a first liquid from the fourth separator, gasifying a first portion of the first liquid. A second portion of the first liquid remains liquid and is natural gas liquids.

Abstract: Described herein are methods of treating inflammatory bowel disease (IBD) in a patient having IBD using SMAD7 antisense oligonucleotides.

Abstract: A flexible support including a body configured to provide anatomical support to a user's appendage, and an insert extending along at least a portion of an edge of the flexible support to reduce irritation and fitment discomfort to the user's appendage from the edge.

Abstract: Honey infused with pollen is a method of infusing pure raw minimally processed honey with minimally processed plant and bee pollen.

Abstract: Provided herein are methods for evaluating the effect of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide or a pharmaceutically acceptable stereoisomer, tautomer, solid form, polymorph, salt, hydrate, clathrate, or solvate thereof in a patient with an assay based on UVB-irradiation and phosphorylated c-Jun expression. The analyses allow for evaluation of dose-response and identification of patient populations who are sensitive to 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide or a pharmaceutically acceptable stereoisomer, tautomer, solid form, polymorph, salt, hydrate, clathrate, or solvate thereof.

Abstract: Described herein are combinations comprising a SMAD7 oligonucleotide and a Toll-like receptor (TLR) modulator. Methods for using such combinations to treat disease conditions, including inflammatory disorders, such as inflammatory bowel disease (IBD), are also provided herein.

Abstract: A flexible support including a body configured to provide anatomical support to a user's appendage, and an insert extending along at least a portion of an edge of the flexible support to reduce irritation and fitment discomfort to the user's appendage from the edge.

Abstract: The comprehensive result of the present invention contains raw honey, bee pollen, and/or manually collected pollen. The pollens are frozen to prevent spoilage. Upon collecting all of the desired pollens, the pollens are mixed together and thoroughly blended with raw honey to create a product, with extended shelf life, containing a known variety of pollens.

Abstract: A thermally regulated penile prosthetic system includes a prosthetic capsule extending longitudinally from a base to define a shaft region terminating at a tip region. The prosthetic capsule includes an inner capsule portion nested within an outer capsule portion and a fluid cushion captured therebetween. The inner capsule portion defines an inner bore extending from the base region longitudinally through the shaft region, the inner capsule portion being supported with respect to the outer capsule portion at the tip region by a stabilizing member. A heating source is coupled to transfer heat to the prosthetic capsule; and, an outer skin layer extends substantially about at least a portion of the shaft region of the prosthetic capsule. The outer skin layer is configured to emulate penile shaft skin.

Abstract: Provided herein are methods for evaluating the effect of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide or a pharmaceutically acceptable stereoisomer, tautomer, solid form, polymorph, salt, hydrate, clathrate, or solvate thereof in a patient with an assay based on UVB-irradiation and phosphorylated c-Jun expression. The analyses allow for evaluation of dose-response and identification of patient populations who are sensitive to 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide or a pharmaceutically acceptable stereoisomer, tautomer, solid form, polymorph, salt, hydrate, clathrate, or solvate thereof.

Abstract: An apparatus that accelerates curing of resin in a liner for a buried pipe includes a lining assembly connected to a pressurized fluid source. One embodiment includes an inversion cap having an inversion port, a curing port and a drainage port. The apparatus also includes a manifold having an outlet, a first inlet in valved fluid communication with a heated fluid source, a second inlet in valved fluid communication with a pressurized fluid source and a third inlet in valved fluid communication with the drainage port. While heated fluid enters the first end of the assembly via the manifold, a release fitting which allows fluids to escape through the second end thereof.

Abstract: Provided herein are methods for evaluating the effect of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide or a pharmaceutically acceptable stereoisomer, tautomer, solid form, polymorph, salt, hydrate, clathrate, or solvate thereof in a patient with an assay based on UVB-irradiation and phosphorylated c-Jun expression. The analyzes allow for evaluation of dose-response and identification of patient populations who are sensitive to 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide or a pharmaceutically acceptable stereoisomer, tautomer, solid form, polymorph, salt, hydrate, clathrate, or solvate thereof.

Abstract: A U-turn signaling device for a vehicle for signaling that the driver is going to or is currently performing a U-turn. The U-turn signaling device includes a headlight assembly and a taillight assembly, wherein each light assembly includes a U-shaped light therein. A control circuit includes an activation device, a microprocessor, and the U-shaped lights of the light assemblies. Depending upon the embodiment, the activation device may be used to selectively or automatically illuminate the U-shaped lights so as to indicate to other drivers that the driver is performing a U-turn.

Abstract: Provided herein are methods for evaluating the effect of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide or a pharmaceutically acceptable stereoisomer, tautomer, solid form, polymorph, salt, hydrate, clathrate, or solvate thereof in a patient with an assay based on UVB-irradiation and phosphorylated c-Jun expression. The analyses allow for evaluation of dose-response and identification of patient populations who are sensitive to 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide or a pharmaceutically acceptable stereoisomer, tautomer, solid form, polymorph, salt, hydrate, clathrate, or solvate thereof.

Abstract: An apparatus and method that accelerates curing of resin in a liner for a buried pipe includes an air inversion unit connected to an air compressor. The apparatus include a curing cap having an inflation port, a curing port and a drainage port. A remote source of pressurized fluid is placed in fluid communication with the inflation port. The apparatus also includes a manifold having an outlet, a first inlet in valved fluid communication with a heated fluid source, a second inlet in valved fluid communication with a pressurized fluid source and a third inlet in valved fluid communication with the drainage port. A flexible tube is slidably received by the curing port while maintaining a substantially fluid-tight seal. The flexible tube has a first end in fluid communication with the outlet of the manifold and the second end has a substantially spherical guide thereon. The second end of the flexible tube also includes a plurality of perforations to allow fluids to pass there through.