Abstract: Integrated circuits and methods to provide an operative coupling comprising an input stage and an output stage between an analog input and an analog output; synchronously operate a plurality of high voltage domain switches of the input stage and a plurality of low voltage domain switches of the output stage at a frequency to galvanically isolate the input stage from the output stage across a plurality of capacitors having a plurality of input plates respectively connected to the switches of the input and output stages; supply an analog input signal to the input stage; transfer a differential voltage signal component within a range of a common mode voltage supply from the high voltage domain of the input stage to the low voltage domain of the output stage; differentially amplify the low voltage domain differential voltage signal component; and output an analog output signal.

Abstract: An integrated circuit (IC) package includes a partial leadframe including (a) a shunt resistor leadframe element including a pair of shunt resistor contacts and a shunt resistor conductively connected between the pair of shunt resistor contacts and (b) at least one external contact leadframe element separate from the shunt resistor leadframe element, the at least one external contact leadframe element allowing external contact to the IC package. The IC package also a mold encapsulation formed over the shunt resistor leadframe element, wherein the pair of shunt resistor contacts are externally contactable through the mold encapsulation.

Abstract: The invention relates to crystalline polymorphic manifestations of a compound of formula (I) and related aspects.

Abstract: The invention provides anhydrous and hydrated forms of sodium salt of N-[[4-(3,4-dichlorophenoxy)[1,4?-bipiperidin]-1?-yl]carbonyl]-4-methyl-benzenesulfonamide and crystalline forms of N-[[4-(3,4-dichlorophenoxy)[1,4?-bipiperidin]-1?-yl]carbonyl]-4-methyl-benzenesulfonamide; and such compounds are modulators of chemokine (especially CCR3) activity and are especially useful for treating asthma and/or rhinitis.

Abstract: A fire suppression device characterized by a plunger that is extendible from a housing for delivery of a fire suppressant foam. The plunger may be equipped at its outer end with a puncture tip that can penetrate through the wall of a container or cargo cover for delivery of the fire suppressant foam directly to the cargo, preferably after full or almost full extension of the plunger. The plunger may be driven outwardly under high force by a pressurized gas that may also be used as a propellant for mixing with a liquid foaming agent, preferably within a foaming chamber carried by the piston. Provision may also be made for connection to a source of pressurized fluid to effect retraction of the plunger.

Abstract: Pressurized aerosol composition comprising a liquefied hydrofluorocarbon propellant of formula CxHyFz where x is an integer from 1 to 3, y+z=2x+2, and y and z are both at least 1; from 0.01 to 15% w/w of a particulate medicament dispersed in the liquefied hydrofluorocarbon propellant; and from 0.01 to 10% w/w of a fluorinated surfactant which is soluble in the liquefied hydrofluorocarbon propellant. The pressurized aerosol composition comprises no solvent, other than the liquefied hydrofluorocarbon propellant.

Abstract: A pharmaceutical composition comprising a nucleotide analogue, mannitol and a modifying additive which is sodium chloride or a polyol which is suitable for freeze drying.