Abstract: The disclosure provides synthetic (e.g. recombinant) pneumococcal saccharide comprising one or more repeat unit(s) ?4)-?-D-Glcp-(1?3)-[[?-L-Rhap-(1?2)]-[Gro-(2?P?3)]-?-D-Galp-(1?4)]-?-L-Rhap-(1?. Also provided are conjugates comprising a ?4)-?-D-Glcp-(1?3)-[[?-L-Rhap-(1?2)]-[Gro-(2?P?3)]-?-D-Galp-(1?4)]-?-L-Rhap-(1?, immunogenic compositions, vaccines and their use in preventing or treating infection by Streptococcus pneumoniae.

Abstract: The present disclosure relates to the treatment of a skin condition in a subject, including but not limited to one or more of luminosity, brightness, skin pore size, skin pore count, sebum production, sebum composition, overall skin quality, eyelid laxity, fine lines under the eye, fine lines on the face, laxity on the face, perioral rhytids, moderate to severe facial folds and wrinkles such as nasolabial folds, moderate to severe facial wrinkles such as smile lines or marionette lines, age-related midface contour deficiencies, dorsal hand to correct volume deficit, glabellar lines, correction of facila depressions, either due to injury or age-related, perioral wrinkles, lip commissures, crow's feet, facial rhytides, and forehead wrinkles, comprising applying to the skin of the subject a first composition derived from one or more sponges, and a second composition comprising one or more botulinum toxins.

Abstract: An oral insert includes a plurality of manifolds and a plurality of fluid nozzles. A manifold switch is coupled to the plurality of manifolds. The manifold switch is configured to select which of the plurality manifolds is to receive fluid from a fluid source.

Abstract: Described herein are systems and methods for providing personalized oral irrigation. One variation of a system for personalized oral irrigation comprises a fluid reservoir and a customized oral insert in fluid communication with the fluid reservoir. The oral insert comprises an arrangement of fluid openings positioned based on the individual oral or dental structures of a user's teeth to provide a customized fluid flow over the user's teeth. Also described herein are methods for generating an arrangement of fluid openings in a customized oral insert.

Abstract: The system and methods described herein aids in the defense of unmanned vehicles, such as aerial vehicles, from wifi cyber attacks. Such attacks usually do not last long and in the case of many point-to-point command and control systems, the attacks originate from close proximity to the unmanned vehicle. The system and methods described herein allow a team to rapidly identify and physically respond to an adversary trying to take control of the unmanned vehicle. Another aspect of the embodiment taught herein is to allow for the location of a wifi signal in a hands-free manner by able to visualize the source of the signal using an augmented reality display coupled to an antenna array.

Abstract: The present disclosure relates to the treatment of diseases or conditions in a subject, including skin conditions or diseases, comprising applying to the skin of the subject a first composition comprising Spongilla, and a second composition comprising an effective amount of one or more dermal fillers, wherein said dermal fillers are selected from a chemical compound, a mixture of chemical compounds, a biological macromolecule, or an extract made from biological materials. Further provided are such methods wherein the one or more dermal fillers is selected from a group comprising of commercially available dermal fillers.

Abstract: Described herein are systems and methods for providing personalized oral irrigation. One variation of a system for personalized oral irrigation comprises a fluid reservoir and a customized oral insert in fluid communication with the fluid reservoir. The oral insert comprises an arrangement of fluid openings positioned based on the individual oral or dental structures of a user's teeth to provide a customized fluid flow over the user's teeth. Also described herein are methods for generating an arrangement of fluid openings in a customized oral insert.

Abstract: The present disclosure relates to the treatment of a skin condition in a subject, including but not limited to one or more of luminosity, brightness, skin pore size, skin pore count, sebum production, sebum composition, overall skin quality, eyelid laxity, fine lines under the eye, fine lines on the face, laxity on the face, perioral rhytids, moderate to severe facial folds and wrinkles such as nasolabial folds, moderate to severe facial wrinkles such as smile lines or marionette lines, age-related midface contour deficiencies, dorsal hand to correct volume deficit, glabellar lines, correction of facila depressions, either due to injury or age-related, perioral wrinkles, lip commissures, crow's feet, facial rhytides, and forehead wrinkles, comprising applying to the skin of the subject a first composition derived from one or more sponges, and a second composition comprising one or more botulinum toxins.

Abstract: The present disclosure relates to the treatment of skin condition in a subject, including acne vulgaris, comprising applying to the skin of the subject a first composition comprising Spongilla, and a second composition comprising one or more fluidizing agents, such as water, saline or a hydrogen peroxide solution. The disclosure also relates to a products or kits for the treatment of skin conditions in a subject, including acne vulgaris, comprising Spongilla, and a second composition comprising one or more fluidizing agents, such as water, saline or a hydrogen peroxide solution, such as a 3% by weight solution of hydrogen peroxide.

Abstract: A Tamper Switch Assembly to protect cryptographic modules and electronic components within a closeable unit. The Tamper Switch Assembly includes a Lid Switch Actuator affixable to an underside of a lid of the closeable unit, and a Lid Switch Guard Bracket affixable within a chassis of the closeable unit. The Tamper Switch Assembly includes an Electronic Switch Assembly insertable within the Lid Switch Guard Bracket to provide electrical monitoring of a switch state. A microprocessor is coupled to the Electronic Switch Assembly by communication means to monitor the switch for electrical continuity to determine its state, and in response, determine whether a tampering of the securely closed unit has occurred. Other embodiments are disclosed.

Abstract: The present disclosure relates to the treatment of diseases or conditions in a subject, including skin conditions or diseases, comprising applying to the skin of the subject a first composition comprising Spongilla, and a second composition comprising a therapeutically effective amount of one or more drugs, wherein said drugs are selected from a chemical compound, a mixture of chemical compounds, a biological macromolecule, or an extract made from biological materials. Further provided are such methods wherein the one or more biological macromolecules is selected from a recombinant protein, a fusion protein, an antibody, a monoclonal antibody, a humanized monoclonal antibody, a bivalent antibody, an antibody fragment, an antibody-drug conjugate, a Fc fragment, a Fab fragment, a Fab? fragment, a (Fab?)2 fragment, a Fv fragment, and a scFv fragment.

Abstract: A tamper sensor assembly includes a lid having a surface and a sensor substrate on the surface of the lid. The sensor substrate has conductive lines that extend across at least a major portion of the surface of the lid and conform to three dimensional characteristics of the surface of the lid. The security processor is electrically connected to the conductive lines of the sensor substrate and is configured to identify occurrence of tampering with the lid based on an electrical characteristic of signals conducted through the conductive lines, and to perform an anti-tampering operation responsive to identifying occurrence of tampering.

Abstract: Described herein are systems and methods for providing personalized oral irrigation. One variation of a system for personalized oral irrigation comprises a fluid reservoir and a customized oral insert in fluid communication with the fluid reservoir. The oral insert comprises an arrangement of fluid openings positioned based on the individual oral or dental structures of a user's teeth to provide a customized fluid flow over the user's teeth. Also described herein are methods for generating an arrangement of fluid openings in a customized oral insert.

Abstract: The present disclosure relates to the treatment of a skin condition in a subject, including but not limited to hyperhidrosis, comprising applying to the skin of the subject a first composition derived from one or more sponges, and a second composition comprising one or more botulinum toxins. Also provided are compositions for use in the treatment of a skin condition in a subject, including but not limited to hyperhidrosis, comprising a first composition and a second composition, wherein (a) the first composition comprises Spongilla; and (b) the second composition comprises one or more botulinum toxins. Also provided are kits, including kits for the treatment of a skin condition in a subject including but not limited to hyperhidrosis, comprising a first composition and a second composition, wherein the first composition comprises Spongilla, and the second composition comprises one or more botulinum toxins.

Abstract: Interleaved data acquisition in optical spectroscopy is used to provide interference correction for time-varying interference. Measurements at a reference frequency are used to provide an estimate of the interference. These reference measurements are interleaved with the remaining measurements in order to provide estimates of the interference vs. time at relevant times. The interference being corrected can be spectrally structured or unstructured.

Abstract: The system and methods described herein aids in the defense of unmanned vehicles, such as aerial vehicles, from wifi cyber attacks. Such attacks usually do not last long and in the case of many point-to-point command and control systems, the attacks originate from close proximity to the unmanned vehicle. The system and methods described herein allow a team to rapidly identify and physically respond to an adversary trying to take control of the unmanned vehicle. Another aspect of the embodiment taught herein is to allow for the location of a wifi signal in a hands-free manner by able to visualize the source of the signal using an augmented reality display coupled to an antenna array.

Abstract: Described herein are systems and methods for providing personalized oral irrigation. One variation of a system for personalized oral irrigation comprises a fluid reservoir and a customized oral insert in fluid communication with the fluid reservoir. The oral insert comprises an arrangement of fluid openings positioned based on the individual oral or dental structures of a user's teeth to provide a customized fluid flow over the user's teeth. Also described herein are methods for generating an arrangement of fluid openings in a customized oral insert.

Abstract: A point-of-sale system for concurrently processing multiple point of sale transactions, each point of sale transaction including an item input portion and a payment portion of the transaction, each portion performed in series. The point-of-sale system comprises a customer facing terminal and a merchant facing terminal. The system can comprise a plurality of customer facing terminals and can be portable. The customer facing terminal is configured to receive an input of payment information for a first point of sale transaction during a payment portion of the first point of sale transaction. The merchant facing terminal is configured to receive an input of an item selection for a second point of sale transaction during an item input portion of the second point of sale transaction and during the payment portion of the first point of sale transaction.

Abstract: A point-of-sale system for concurrently processing multiple point of sale transactions, each point of sale transaction including an item input portion and a payment portion of the transaction, each portion performed in series. The point-of-sale system comprises a customer facing terminal and a merchant facing terminal. The system can comprise a plurality of customer facing terminals and can be portable. The customer facing terminal is configured to receive an input of payment information for a first point of sale transaction during a payment portion of the first point of sale transaction. The merchant facing terminal is configured to receive an input of an item selection for a second point of sale transaction during an item input portion of the second point of sale transaction and during the payment portion of the first point of sale transaction.

Abstract: The present disclosure relates to methods for treating intestinal diseases presenting at least one inflammatory component such as inflammatory bowel disease or diverticular disease and/or maintaining remission of intestinal diseases presenting at least one inflammatory component such as inflammatory bowel disease (IBD) or diverticular disease using budesonide MMX compositions.