Abstract: A biopsy sampling device comprises a handle with a flexible cannula extending from the handle. The flexible cannula includes: an inner catheter, which defines an opening in a lateral wall surface thereof, and further defines a central lumen in fluid communication with the opening; an outer catheter positioned around and moveable relative to the inner catheter; and a cutting element positioned at a distal end of the outer catheter. The flexible cannula is configured such that a vacuum can be applied through the central lumen of the inner catheter to create a suction that draws a piece of tissue into the opening defined in the lateral wall surface of the inner catheter. The handle is configured to move the inner catheter relative to the outer catheter, such that the cutting element shears and severs the piece of tissue that has been drawn into the opening.

Abstract: A biopsy sampling device comprises a handle with a flexible cannula extending from the handle. The flexible cannula includes: an inner catheter, which defines an opening in a lateral wall surface thereof, and further defines a central lumen in fluid communication with the opening; an outer catheter positioned around and moveable relative to the inner catheter; and a cutting element positioned at a distal end of the outer catheter. The flexible cannula is configured such that a vacuum can be applied through the central lumen of the inner catheter to create a suction that draws a piece of tissue into the opening defined in the lateral wall surface of the inner catheter. The handle is configured to move the inner catheter relative to the outer catheter, such that the cutting element shears and severs the piece of tissue that has been drawn into the opening.

Abstract: An endoscopic overtube assembly comprises: an inflatable overtube; and a subassembly configured for insertion into an orifice of a patient, said subassembly defining a central passageway, and said subassembly including an internal cassette for receiving and securing the inflatable overtube, wherein the internal cassette of said subassembly can be manipulated from a closed position to an open position in which the inflatable overtube can be readily extended and deployed from said subassembly. The inflatable overtube travels with the endoscopic device. Once appropriately positioned, the inflatable overtube is detached from the endoscopic device and inflated to become a substantially rigid conduit defining an instrument channel that provides ready access to a particular body cavity.