Patents by Inventor Gerald W. Fischer

Gerald W. Fischer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Opsonic and protective monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria
    Publication number: 20020082395
    Abstract: The present invention encompasses monoclonal and chimeric antibodies that bind to lipoteichoic acid of Gram positive bacteria. The antibodies also bind to whole bacteria and enhance phagocytosis and killing of the bacteria in vitro and enhance protection from lethal infection in vivo. The mouse monoclonal antibody has been humanized and the resulting chimeric antibody provides a previously unknown means to diagnose, prevent and/or treat infections caused by gram positive bacteria bearing lipoteichoic acid. This invention also encompasses a peptide mimic of the lipoteichoic acid epitope binding site defined by the monoclonal antibody. This epitope or epitope peptide mimic identifies other antibodies that may bind to the lipoteichoic acid epitope. Moreover, the epitope or epitope peptide mimic provides a valuable substrate for the generation of vaccines or other therapeutics.
    Type: Application
    Filed: June 29, 2001
    Publication date: June 27, 2002
    Applicant: Sunol Molecular Corporation
    Inventors: Gerald W. Fischer, Richard F. Schuman, Hing Wong, Jeffrey R. Stinson
  • Directed human immune globulin for the prevention and treatment of staphylococcal infections
    Patent number: 5955074
    Abstract: This invention is directed to a Directed Human Immoglobulin and compositions thereof for preventing or treating staphylococcal infections such as S. epidermidis in neonates.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: September 21, 1999
    Assignee: Henry M. Jackson Foundation for the Advancement of Military Medicine
    Inventor: Gerald W. Fischer
  • Broadly reactive opsonic antibodies that react with common staphylococcal antigens
    Patent number: 5571511
    Abstract: The invention relates to the identification, making, and isolation of immunoglobulin and antigen that is useful to prevent, diagnose, or treat Staphylococcus infections. The invention further relates to an in vivo animal model for testing the efficacy of pharmaceutical compositions, including the pharmaceutical compositions of immunoglobulin and isolated antigen described herein.
    Type: Grant
    Filed: March 28, 1994
    Date of Patent: November 5, 1996
    Assignee: The U.S. Government
    Inventor: Gerald W. Fischer
  • Human monoclonal antibody reactive with polyribosylribitol phosphate
    Patent number: 4954449
    Abstract: A human monoclonal antibody produced by a self-reproducing carrier cell, antibody being reactive with PRP capsular polysaccharide. Also disclosed is a process of preparing the antibody from the carrier cell, which is conveniently a hybridoma. Additionally, diagnostic, prophylactic and therapeutic compositions and methods employing the antibody are disclosed. Moreover, a laboratory reagent containing the antibody is described.
    Type: Grant
    Filed: February 12, 1988
    Date of Patent: September 4, 1990
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Kenneth W. Hunter, Gerald W. Fischer
  • Human monoclonal antibody reactive with polyribosylribitol phosphate
    Patent number: 4744982
    Abstract: A human monoclonal antibody produced by a self-reproducing carrier cell, the antibody being reactive with PRP capsular polysaccharide. Also disclosed is a process of preparing the antibody from the carrier cell, which is conveniently a hybridoma. Additionally, diagnostic, prophylactic and therapeutic compositions and methods employing the antibody are disclosed. Moreover, a laboratory reagent containing the antibody is described.
    Type: Grant
    Filed: August 24, 1982
    Date of Patent: May 17, 1988
    Inventors: Kenneth W. Hunter, Gerald W. Fischer