Patents by Inventor Gerald W. Shipps

Gerald W. Shipps has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrazolopyrimidines as protein kinase inhibitors
    Patent number: 7449488
    Abstract: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of protein and/or checkpoint kinases, methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of preparing pharmaceutical formulations including one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the protein or checkpoint kinases using such compounds or pharmaceutical compositions. The invention also relates to the inhibition of hepatitis C virus (HCV) replication. In particular, embodiments of the invention provide compounds and methods for inhibiting HCV RNA-dependent RNA polymerase enzymatic activity. The invention also provides compositions and methods for the prophylaxis and treatment of HCV infection.
    Type: Grant
    Filed: October 6, 2005
    Date of Patent: November 11, 2008
    Assignee: Schering Corporation
    Inventors: Kamil Paruch, Timothy J. Guzi, Michael P. Dwyer, Gerald W. Shipps, Jr.
  • High affinity thiophene-based and furan-based kinase ligands
    Patent number: 7446195
    Abstract: Inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provides for methods of making CDK-2 inhibitor compounds, methods of inhibiting CDK-2, and methods for treating disease or disease symptoms.
    Type: Grant
    Filed: August 16, 2006
    Date of Patent: November 4, 2008
    Assignee: Schering Corporation
    Inventors: Yongqi Deng, Lianyun Zhao, Gerald W. Shipps, Jr., Patrick J. Curran, M. Arshad Siddiqui, Rumin Zhang, Charles W. McNemar, Todd W. Mayhood, William T. Windsor, Emma M. Lees, David A. Parry
  • Substituted 5-carboxyamide pyrazoles and [1,2,4]triazoles as antiviral agents
    Patent number: 7425640
    Abstract: The present invention provides compounds of formula I wherein X, Y, R1-R7 are as defined herein. Compositions containing these compounds, and methods for inhibiting HCV RNA-dependent RNA polymerase and treating hepatitis C and related disorders using these compounds and compositions are also provided.
    Type: Grant
    Filed: October 26, 2005
    Date of Patent: September 16, 2008
    Assignee: Schering Corporation
    Inventors: Alan B. Cooper, Hugh Y. Zhu, James J-S Wang, Jagdish A. Desai, Gerald W. Shipps, Jr., Patrick J. Curran, D. Allen Annis, Huw M. Nash, Viyyoor M. Girijavallabhan
  • Novel high affinity quinoline-based kinase ligands
    Publication number: 20080045568
    Abstract: Quinoline-based inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provides for methods of making CDK-2 inhibitor compounds, methods of inhibiting CDK-2, and methods for treating disease or disease symptoms.
    Type: Application
    Filed: August 16, 2006
    Publication date: February 21, 2008
    Inventors: Yongqi Deng, Patrick J. Curran, Gerald W. Shipps, Lianyun Zhao, M. Arshad Siddiqui, Janeta Popovici-Muller, Jose S. Duca, Alan W. Hruza, Thierry O. Fischmann, Vincent S. Madison, Rumin Zhang, Charles W. McNemar, Todd W. Mayhood, William T. Windsor, Emma M. Lees, David A. Parry
  • Method of Using Substituted Piperidines that Increase P53 Activity
    Publication number: 20080004286
    Abstract: The present invention discloses a method of using compounds, which have HDM2 protein antagonist activity, to treat or prevent cancer, other diseases caused by abnormal cell proliferation, diseases associated with HDM2, or diseases caused by inadequate P53 activity.
    Type: Application
    Filed: June 27, 2007
    Publication date: January 3, 2008
    Inventors: Yaolin Wang, Rumin Zhang, Yao Ma, Brian Robert Lahue, Gerald W. Shipps
  • Pyrazolo[1,5a]pyrimidine compounds as antiviral agents
    Patent number: 7196111
    Abstract: The invention relates to the inhibition of hepatitis C virus (HCV) replication. In particular, embodiments of the invention provide compounds and methods for inhibiting HCV RNA-dependent RNA polymerase enzymatic activity. The invention also provides compositions and methods for the prophylaxis and treatment of HCV infection.
    Type: Grant
    Filed: June 2, 2003
    Date of Patent: March 27, 2007
    Assignee: Schering Corporation
    Inventors: Gerald W. Shipps, Kristin E. Rosner, Janet Popovici-Muller, Yongqi Deng, Tong Wang, Patrick J. Curran
  • CD40:CD154 binding interrupter compounds and use thereof to treat immunological complications
    Patent number: 7173046
    Abstract: The present invention relates to novel CD40:CD154 binding interrupter compounds and use of these compounds and pharmaceutical compositions comprising them, to treat conditions associated with inappropriate CD154 activation in a subject. Specifically, this invention provides compounds which are identified by screening a library of small molecules for those that are capable of specifically binding CD154 and interrupting CD40:CD154 interaction.
    Type: Grant
    Filed: February 28, 2003
    Date of Patent: February 6, 2007
    Assignee: Biogen, Inc.
    Inventors: Zhongli Zheng, Mary-Beth Carter, YuSheng Liao, Lihong Sun, Leonid Kirkovsky, Susan Mrose, Yen-Ming Hsu, David Thomas, Gerald W. Shipps, Jr., Satish Jindal, George R. Lenz, Huw M. Nash
  • Substituted 5-oxo pyrazoles and [1,2,4]triazoles as antiviral agents
    Patent number: 7115749
    Abstract: The present invention provides compounds of formula I wherein X and R1–R7 are as defined herein.
    Type: Grant
    Filed: October 26, 2005
    Date of Patent: October 3, 2006
    Assignee: Schering Corporation
    Inventors: Gerald W. Shipps, Jr., Tong Wang, Kristin E. Rosner, Patrick J. Curran, Alan B. Cooper, Viyyoor M. Girijavallabhan
  • Novel CD40 : CD154 binding interruptor compounds and use thereof to treat immunological complications
    Publication number: 20040067982
    Abstract: The present invention relates to novel CD40:CD154 binding interrupter compounds and use of these compounds and pharmaceutical compositions comprising them, to treat conditions associated with inappropriate CD154 activation in a subject. Specifically, this invention provides compounds which are identified by screening a library of small molecules for those that are capable of specifically binding CD154 and interrupting CD40:CD154 interaction.
    Type: Application
    Filed: February 28, 2003
    Publication date: April 8, 2004
    Inventors: Zhongli Zheng, Mary-Beth Carter, YuSheng Liao, Lihong Sun, Leonid Kirkovsky, Susan Mrose, Yen-Ming Hsu, David Thomas, Gerald W. Shipps, Satish Jindal, George R. Lenz, Huw M. Nash
  • Pyrazolo[1,5a]pyrimidine compounds as antiviral agents
    Publication number: 20040038993
    Abstract: The invention relates to the inhibition of hepatitis C virus (HCV) replication. In particular, embodiments of the invention provide compounds and methods for inhibiting HCV RNA-dependent RNA polymerase enzymatic activity. The invention also provides compositions and methods for the prophylaxis and treatment of HCV infection.
    Type: Application
    Filed: June 2, 2003
    Publication date: February 26, 2004
    Applicant: Neogenesis Pharmaceuticals, Inc.
    Inventors: Gerald W. Shipps, Kristin E. Rosner, Janeta Popovici-Muller, Yongqi Deng, Tong Wang, Patrick J. Curran
  • Methods for forming combinatorial libraries using reductive amination
    Publication number: 20020115106
    Abstract: The invention relates to methods for forming combinatorial libraries. The invention provides methods suitable for the rapid and convenient synthesis of very large combinatorial libraries of small organic molecules. In particular, the invention provides a method for forming combinatorial libraries combining amide, sulfonamide, or urea bond formation with reductive amination.
    Type: Application
    Filed: December 20, 2001
    Publication date: August 22, 2002
    Applicant: NeoGenesis Pharmaceuticals, Inc.
    Inventors: Gerald W. Shipps, Kollol Pal
  • Methods for forming combinatorial libraries combining amide bond formation with epoxide opening
    Publication number: 20020077491
    Abstract: The invention relates to methods for forming combinatorial libraries. The invention provides methods suitable for the rapid and convenient synthesis of very large combinatorial libraries of small organic molecules. In particular, the invention provides a method for forming combinatorial libraries combining amide bond formation with epoxide opening.
    Type: Application
    Filed: August 31, 2001
    Publication date: June 20, 2002
    Inventors: Gerald W. Shipps, Kristin E. Rosner, Gergely M. Makara, Edward A. Wintner, Huw M. Nash, Jason S. Felsch, Kollol Pal, George R. Lenz