Patents by Inventor Gerald Wayne Both

Gerald Wayne Both has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • VACCINATION REGIMEN
    Publication number: 20110177115
    Abstract: The present invention provides a method of raising an immune response in a subject against an antigen. The method involves the steps of a) administering to the subject a non-atadenoviral vector comprising a nucleic acid encoding the antigen, and b) administering an engineered atadenovirus to the subject, wherein the genome of the engineered atadenovirus encodes the antigen. Step b) is performed after step a).
    Type: Application
    Filed: October 4, 2010
    Publication date: July 21, 2011
    Inventors: Tomas Hanke, Gerald Wayne Both
  • Modified gene-silencing nucleic acid molecules and uses thereof
    Publication number: 20110076681
    Abstract: Methods and means for efficiently downregulating the expression of a target gene of interest in cell from an organism that is an animal, fungus, and protest. The invention provides chimeric nucleic acid molecules for downregulating target genes. The invention also provides modified cells and organisms comprising the chimeric nucleic acid molecules and compositions comprising the chimeric molecules.
    Type: Application
    Filed: March 31, 2010
    Publication date: March 31, 2011
    Inventors: Peter Michael Waterhouse, Linda Jane Lockett, Ming-Bo Wang, Timothy James Doran, Robert John Moore, Gerald Wayne Both
  • Modified Gene-Silencing Nucleic Acid Molecules and Uses Thereof
    Publication number: 20080044906
    Abstract: Methods and means for efficiently downregulating the expression of a target gene of interest in cell from an organism that is an animal, fungus and protist. The invention provides chimeric nucleic acid molecules for downregulating target genes. The invention also provides modified cells and organisms comprising the chimeric nucleic acid molecules and compositions comprising the chimeric molecules.
    Type: Application
    Filed: September 10, 2004
    Publication date: February 21, 2008
    Inventors: Peter Michael Waterhouse, Linda Jane Lockett, Ming-Bo Wang, Timothy James Doran, Robert John Moore, Gerald Wayne Both
  • DNA encoding ovine adenovirus (OAV287) and its use as a viral vector
    Patent number: 7037712
    Abstract: A genome of an ovine adenovirus designated OAV287 is isolated from sheep and sequenced. Portions of the genome not essential for maintenance or viability of the virus can be deleted or altered. A nucleotide sequence encoding a non-adenoviral polypeptide can be incorporated into the genome. The a full-length clone of the genome can be provided as part of a plasmid or viral vector. Cells can be transformed with a vector of the invention such that they express an exogenous protein.
    Type: Grant
    Filed: December 16, 1999
    Date of Patent: May 2, 2006
    Assignee: Commonwealth Scientific and Industrial Research Organisation
    Inventors: Gerald Wayne Both, David Bernard Boyle, Sadhanshu Vrati
  • DNA ENCODING OVINE ADENOVIRUS (OAV287) AND ITS USE AS A VIRAL VECTOR
    Publication number: 20020045249
    Abstract: A genome of an ovine adenovirus designated OAV287 is isolated from sheep and sequenced. Portions of the genome not essential for maintenance or viability of the virus can be deleted or altered. A nucleotide sequence encoding a non-adenoviral polypeptide can be incorporated into the genome. The a full-length clone of the genome can be provided as part of a plasmid or viral vector. Cells can be transformed with a vector of the invention such that they express an exogenous protein.
    Type: Application
    Filed: December 16, 1999
    Publication date: April 18, 2002
    Inventors: GERALD WAYNE BOTH, DAVID BERNARD BOYLE, SUDHANSHU VRATI
  • Nucleic acid delivery with ovine adenoviral vectors
    Patent number: 6020172
    Abstract: A method of delivering a nucleic acid molecule to a human cell which involves exposing to the cell a viral vector containing a DNA molecule including a nucleic acid sequence encoding the genome of an ovine adenovirus capable of infecting human cells or functionally equivalent nucleic acid sequence or portion thereof and at least one nucleic acid sequence encoding a gene to be expressed in the cell, such that the vector infects the cell and the infected cell expresses the gene.
    Type: Grant
    Filed: April 20, 1998
    Date of Patent: February 1, 2000
    Assignee: Commonwealth Scientific and Industrial Research Organisation
    Inventor: Gerald Wayne Both