Abstract: The present application relates to various uses of thiazolidine derivatives of compounds of Formula II in the treatment of diseases, disorders or conditions that are treatable by inhibiting interactions between Cav3.2 T-type calcium channels (Cav3.2) and ubiquitin specific peptidase 5 (USPS). For example, the one or more compounds of Formula II are useful as an analgesic in the treatment of pain. The present application also relates to compounds of Formula I or pharmaceutically acceptable salts, solvates and/or prodrugs thereof.

Abstract: The present invention provides T-type calcium channel modulators and methods for producing and using the same. In some embodiments, compounds of the invention are of the formula: where R1 is selected from the group consisting of alkyl, alkenyl, polyether, alkoxy and cycloalkyl; X is selected from the group consisting of methylene, —C(?O)—[NR4]a—, —C(?S)—, and —S(?O)b; R2 is selected from the group consisting of heterocycloalkyl and heteroaryl; R3 is selected from the group consisting of alkyl, alkenyl, polyether, alkoxy, cycloalkyl, —NR5R6, —C(?O)NR5R6, —C(?O)ORa (where Ra is alkyl, typically C1-C8 alkyl, often C2-C6 alkyl, and in one particular embodiment Ra is tert-butyl), and —SO2NR5R6; R4 is hydrogen, alkyl, or a nitrogen protecting group; each of R5 and R6 are independently selected from the group consisting of hydrogen and alkyl; a is 0 or 1; b is 1 or 2; n=1 to 3; and m=0 to 1.

Abstract: The present invention provides T-type calcium channel modulators and methods for producing and using the same. In some embodiments, compounds of the invention are of the formula: where R1 is selected from the group consisting of alkyl, alkenyl, polyether, alkoxy and cycloalkyl; X is selected from the group consisting of methylene, —C(?O)—[NR4]a, —C(?S)—, and —S(?O)b; R2 is selected from the group consisting of heterocycloalkyl and heteroaryl; R3 is selected from the group consisting of alkyl, alkenyl, polyether, alkoxy, cycloalkyl, —NR5R6, —C(?O)NR5R6, —C(?O)ORa (where Ra is alkyl, typically C1-C8 alkyl, often C2-C6 alkyl, and in one particular embodiment Ra is tert-butyl), and —SO2NR5R6; R4 is hydrogen, alkyl, or a nitrogen protecting group; each of R5 and R6 are independently selected from the group consisting of hydrogen and alkyl; a is 0 or 1; b is 1 or 2; n=1 to 3; and m=0 to 1.

Abstract: The invention relates to a cooling system for an internal combustion engine on a vehicle, preferably for an agricultural or industrial commercial vehicle. The cooling system includes a high temperature circuit and a low-temperature circuit. The high temperature circuit cools the internal combustion engine and includes at least a first cooler. The low temperature circuit cools a charge air cooler and, optionally, an oil cooler and includes at least one second cooler. The charge air cooler has at least two parts or stages. In the direction of flow of coolant in the low temperature circuit, the second cooler is connected downstream of a first part of the charge air cooler, the oil cooler and a second part of the charge air cooler. Alternatively or additionally, a further cooling circuit cools the charge air cooler and includes at least one cooler.

Abstract: A fan assembly for an agricultural tractor includes a rotatable fan mechanically driven by a drive shaft coupled to an internal combustion engine. A fan shroud encloses the outer periphery of the fan and is mechanically connected to the engine. A bearing is mounted on the drive shaft and supports the fan shroud so that the drive shaft is rotatable with respect to the fan shroud. The bearing prevents radial and axial movement of the fan shroud relative to the drive shaft. A fan housing is connected to a radiator which is connected to the engine. The fan housing is coupled to an end of the fan shroud by a friction coupler which prevents rotation of the fan shroud.

Abstract: A method is described to legally purchase digitally encoded music, audiobooks, and video for direct electronic transmission to a designated recipient to ensure that the designated recipient receives full rights to use the content. The rights conveyed to the recipient are similar or identical to the rights that would have been available to the recipient had he or she purchased the work directly from the owner of those rights.

Abstract: A fan assembly for an agricultural tractor includes a rotatable fan mechanically driven by a drive shaft coupled to an internal combustion engine. A fan shroud encloses the outer periphery of the fan and is mechanically connected to the engine. A bearing is mounted on the drive shaft and supports the fan shroud so that the drive shaft is rotatable with respect to the fan shroud. The bearing prevents radial and axial movement of the fan shroud relative to the drive shaft. A fan housing is connected to a radiator which is connected to the engine. The fan housing is coupled to an end of the fan shroud by a friction coupler which prevents rotation of the fan shroud.

Abstract: A cooling system is provided for a vehicle with an internal combustion engine. The cooling system includes a high temperature cooling circuit and a low temperature cooling circuit that is separated from the high temperature cooling circuit. The high temperature cooling circuit cools the engine and includes at least one cooler. The low temperature cooling circuit cools an oil cooler and, if necessary, a charge air cooler and includes a cooler. The oil cooler may be connected with the high temperature cooling circuit so the oil temperature may be controlled within a narrow temperature range.

Abstract: A cooling system is provided for a vehicle with an internal combustion engine. The cooling system includes a high temperature cooling circuit and a low temperature cooling circuit that is separated from the high temperature cooling circuit. The high temperature cooling circuit cools the engine and includes at least one cooler. The low temperature cooling circuit cools an oil cooler and, if necessary, a charge air cooler and includes a cooler. The oil cooler may be connected with the high temperature cooling circuit so the oil temperature may be controlled within a narrow temperature range.

Abstract: An oil cooler for an internal combustion engine includes an oil circuit and a cooling circuit arranged in a housing with inlet opening and outlet openings. The housing has a generally annular, C-shaped structure which forms a central, axial cylindrical bore and a radially extending slot. The housing is attached to an annular plate. The bore may receive engine components, such as shafts and the like.

Abstract: An oil cooler for an internal combustion engine includes an oil circuit and a cooling circuit arranged in a housing with inlet opening and outlet openings. The housing has a generally annular, C-shaped structure which forms a central, axial cylindrical bore and a radially extending slot. The housing is attached to an annular plate. The bore may receive engine components, such as shafts and the like.

Abstract: Compounds of the formula wherein m is 0, 1 or 2; wherein when m is O, Z is O, when m is 1, Z is N, and when m is 2, Z is C; Y is H, OH, NH2, or an organic moiety of 1-20C, optionally additionally containing 1-8 heteaoms selected from te group consisting of N, P, O, S and halo; each 11 and 2 is independently 0-5; 13is 0 or 1; each of R1, R2 and R3 is independently alkyl (1-6C), aryl (6-10C) or arylalkyl (7-16C) optionally containing 14 heteroatoms selected from the group consisting of halo, N, P, O, and S or each of R1 and R2 may independently be halo, COOR, CONR2, CF3, CN or NO2, wherein R is H or lower alkyl (1-4C) or alkyl (1-6C); n is 0 or 1; X is a linker, with the proviso that Y is not a tropolone, a coumarin, or an antioxidant containing an aromatic group and with the further proviso that if 13 is 0, neither R′ nor R2 can represent F in the para position; and are useful as calcium channel blockers.

Abstract: Compounds of the formula ##STR1## wherein m is 0, 1 or 2; wherein when m is 0, Z is O, when m is 1, Z is N, and when m is 2, Z is C;Y is H, OH, NH.sub.2, or an organic moiety of 1-20C, optionally additionally containing 1-8 heteroatoms selected from the group consisting of N, P, O, S and halo;each I.sup.1 and I.sup.2 is independently 0-5;I.sup.3 is 0 or 1;each of R.sup.1, R.sup.2 and R.sup.3 is independently alkyl (1-6C), aryl (6-10C) or arylalkyl (7-16C) optionally containing 1-4 heteroatoms selected from the group consisting of halo, N, P, O, and S or each of R.sup.1 and R.sup.2 may independently be halo, COOR, CONR.sub.2, CF.sub.3, CN or NO.sub.2, wherein R is H or lower alkyl (1-4C) or alkyl (1-6C);n is 0 or 1;X is a linker;with the proviso that Y is not a tropolone, a coumarin, or an antioxidant containing an aromatic group and with the further proviso that if I.sup.3 is 0, and either I.sup.1 and I.sup.2 is 0 or 1 and if R.sup.1 and/or R.sup.