Patents by Inventor Gerald Wertheim

Gerald Wertheim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for detecting genomic DNA methylation
    Patent number: 11473131
    Abstract: The presently disclosed subject matter provides high-throughput methods for performing genomic DNA methylation assessments. The presently disclosed subject matter further provides methods for diagnosing a subject with a disease and/or disorder, and for determining the prognosis of a subject that has a disease and/or disorder. In certain embodiments, the present disclosure provides a diagnostic method that includes obtaining a biological sample from the subject; determining the methylation status of one or more genomic DNA loci in one or more cells of the biological sample; and diagnosing a disease and/or disorder in the subject, wherein the methylation status of the one or more genomic DNA loci indicates the presence of the disease and/or disorder in the subject.
    Type: Grant
    Filed: August 21, 2015
    Date of Patent: October 18, 2022
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Martin Carroll, Stephen Master, Gerald Wertheim, Marlise Luskin
  • METHODS FOR DETECTING GENOMIC DNA METHYLATION
    Publication number: 20170275686
    Abstract: The presently disclosed subject matter provides high-throughput methods for performing genomic DNA methylation assessments. The presently disclosed subject matter further provides methods for diagnosing a subject with a disease and/or disorder, and for determining the prognosis of a subject that has a disease and/or disorder. In certain embodiments, the present disclosure provides a diagnostic method that includes obtaining a biological sample from the subject; determining the methylation status of one or more genomic DNA loci in one or more cells of the biological sample; and diagnosing a disease and/or disorder in the subject, wherein the methylation status of the one or more genomic DNA loci indicates the presence of the disease and/or disorder in the subject.
    Type: Application
    Filed: August 21, 2015
    Publication date: September 28, 2017
    Inventors: Martin Carroll, Stephen Master, Gerald Wertheim, Marlise Luskin
  • HUNK, A SNF1-RELATED KINASE ESSENTIAL FOR MAMMARY TUMOR METASTASIS
    Publication number: 20140234321
    Abstract: This invention relates generally to a novel serine/threonine protein kinase, specifically to hormonally up-regulated, neu-tumor-associated kinase (HUNK); and to the role of HUNK in tumor metastasis, primary tumor development, and the prediction of tumor behavior.
    Type: Application
    Filed: February 7, 2014
    Publication date: August 21, 2014
    Applicant: The Trustees of The University of Pennsylvania
    Inventors: Lewis A. CHODOSH, Gerald Wertheim, Thomas W. Yang
  • Hunk, a snfi-related kinase essential for mammary tumor metastasis
    Publication number: 20090170797
    Abstract: This invention relates generally to a novel serine/threonine protein kinase, specifically to hormonally up-regulated, neu-tumor-associated kinase (HUNK); and to the role of HUNK in tumor metastasis, primary tumor development, and the prediction of tumor behavior.
    Type: Application
    Filed: September 22, 2005
    Publication date: July 2, 2009
    Inventors: Lewis A. Chodosh, Gerald Wertheim, Thomas W. Yang