Patents by Inventor Geraldine GILLESPIE

Geraldine GILLESPIE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MHC: PEPTIDE COMPLEXES
    Publication number: 20240076350
    Abstract: The invention relates to a mutant HLA-E heavy chain comprising one or more mutation which permits the formation of a HLA-E:peptide complex with increased stability when compared to the complex without the mutant HLA-E heavy chain. The invention also relates to a peptide which is capable of being crosslinked to the mutant HLA-E heavy chain, and a protein complex comprising or consisting of the mutant HLA-E heavy chain and peptide.
    Type: Application
    Filed: December 31, 2021
    Publication date: March 7, 2024
    Inventors: Andrew MCMICHAEL, Geraldine GILLESPIE, Max QUASTEL
  • T CELL RECEPTORS AND USES THEREOF
    Publication number: 20240024477
    Abstract: The invention relates to a T cell receptor (TCR) which is HIV-1 specific and HLA-E restricted. Particularly, the TCR is capable of binding to a peptide of RMYSPTSIL or a peptide of RMYSPTSIL in complex with HLA-E, or a peptide of ILVESPAVL or a peptide of ILVESPAVL in complex with HLA-E. The invention also relates to a nucleic acids and vector encoding the TCR.
    Type: Application
    Filed: December 2, 2021
    Publication date: January 25, 2024
    Inventors: Honbing YANG, Geraldine GILLESPIE, Margarida REI, Simon BRACKENRIDGE, Andrew MCMICHAEL, Hong SUN