Patents by Inventor Geraldine O'Neill

Geraldine O'Neill has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for identifying agents which affect cellular morphology, locomotion and death
    Patent number: 6653074
    Abstract: An isolated nucleic acid molecule is provided which encodes a mammalian signal mediator protein, HEF-1, involved in regulation of cellular morphological alterations. The encoded protein comprises an amino-terminal SH3 domain, an internal domain containing several SH2 binding motifs, and a carboxy-terminal effector domain that can induce pseudohyphal budding in yeast. The invention also provides the novel signal mediator protein, and antibodies thereto. These biological molecules are useful as research tools and as diagnostic and therapeutic agents in methods for the identification, detection and regulation of complex signaling events leading to morphological, potentially neoplastic, cellular changes.
    Type: Grant
    Filed: September 25, 2000
    Date of Patent: November 25, 2003
    Assignee: Fox Chase Cancer Center
    Inventors: Erica A. Golemis, Geraldine O'Neill, Sarah Fashena