Abstract: An oral care implement includes a head and a plurality of cleaning elements for enhanced cleaning of the teeth and soft tissue of the oral cavity. One tooth cleaning element has a plurality of bristles adapted to clean teeth. Another cleaning element is connected to the head and has structure defining a channel. The channel is configured to direct fluid in contact with the head toward an edge of the head when the implement is moved. The head also defines a reservoir that is configured to receive a dentifrice therein.

Abstract: An oral care implement includes a head and a plurality of cleaning elements for enhanced cleaning of the teeth and soft tissue of the oral cavity. One tooth cleaning element has a plurality of bristles adapted to clean teeth. Another cleaning element is connected to the head and has structure defining a channel. The channel is configured to direct fluid in contact with the head toward an edge of the head when the implement is moved. The head also defines a reservoir that is configured to receive a dentifrice therein.

Abstract: An orally deliverable pharmaceutical composition comprises a therapeutically effective amount of pramipexole or a pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable excipient, said composition exhibiting at least one of (a) an in vitro release profile wherein on average no more than about 20% of the pramipexole is dissolved within 2 hours after placement of the composition in a standard dissolution test; and (b) an in vivo pramipexole absorption profile following single dose administration to healthy adult humans wherein the time to reach a mean of 20% absorption is greater than about 2 hours and/or the time to reach a mean of 40% absorption is greater than about 4 hours. The composition is useful for oral administration, not more than once daily, to a subject having a condition or disorder for which a dopamine receptor agonist is indicated.