Patents by Inventor Gerard C. Grosveld

Gerard C. Grosveld has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR DETECTING AND MODULATING A NOVEL MTOR COMPLEX
    Publication number: 20140157443
    Abstract: Provided herein is a novel mTOR-comprising complex, mT-ORC3, which comprises mTOR and the Ets transcription factor TEL2. Specific mTORC3 binding agents and modulating agents are provided, along with kits and methods for the detection of mTORC3. Methods of modulating the activity of mTORC3 or modulating cell growth and/or survival are also provided. Further provided are methods for screening for mTORC3 binding agents and for mTORC3 modulating agents. Various methods of diagnosis and treatment are further provided.
    Type: Application
    Filed: April 12, 2012
    Publication date: June 5, 2014
    Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
    Inventors: Gerard C. Grosveld, Frank C. Harwood, Ramon I. Klein-Geltink
  • Stable virus packaging cell lines
    Patent number: 5750396
    Abstract: The field of the invention is recombinant packaging and producer cell lines for producing infectious retroviral vectors. The invention more specifically relates to the generation of pseudotyped retroviral vectors with a broad host range which can be produced at high titers in specially constructed packaging cell lines. Most specifically, the invention relates to the generation of pseudotyped retroviral vectors having vesicular stomatitis virus-G protein (VSV-G) as the membrane-associated viral envelope protein.
    Type: Grant
    Filed: May 8, 1995
    Date of Patent: May 12, 1998
    Assignees: St. Judes Children's Research Hospital, Genetic Therapy, Inc.
    Inventors: Yanping Yang, Elio F. Vanin, Gerard C. Grosveld, Arthur W. Nienhuis