Abstract: Chlamydiae are intracellular bacterial pathogens responsible for a variety of infections. The inventors produced an antibody that is directed against a surface antigen (i.e., CD40) of an antigen presenting cell (i.e., dendritic cell) wherein the heavy chain and/or light chain is conjugated to the MOMP VS4 domain of Chlamydia trachomatis for its use as vaccine.

Abstract: Chlamydiae are intracellular bacterial pathogens responsible for a variety of infections. The inventors have set up candidate vaccines against Chlamydia trachomatis. In particular, the inventors have identified specific epitopes to be included in vaccine candidates thanks to in silico analysis of the amino-acid sequence of these proteins to map predicted MHC-I and -II epitopes by online software (NetMHC-4.0 and NetMHCII-2.3) and peptide binding prediction software. B cell epitopes were also mapped using online software (BepiPred-2.0 and Discotope). Finally, the inventors have generated some specific CD40 or Langerin antibodies comprising one or more identified epitope(s) of the present invention and that are suitable for vaccine purposes. Therefore, the present invention relates to Chlamydia trachomatis (Ct) antigenic polypeptides and uses thereof for vaccine purposes.

Abstract: A bearing arrangement for a turbomachine includes first and second roller element bearings. The first bearing and the second bearing are disposed on opposite axial ends of an intermediate sleeve of the rotating group. The first bearing has a first inner race with a first inner radial surface and a first outer radial surface. The first inner radial surface has a first interference fit with a shaft of the rotating group. The first outer radial surface has a second interference fit with the intermediate sleeve. The second bearing has a second inner race with a second inner radial surface and a second outer radial surface. The second inner race receives the shaft with a clearance fit. The second outer radial surface has a third interference fit with the intermediate sleeve. The second inner race is coaxially aligned with the first inner race and the shaft via coaxial alignment of the intermediate sleeve and the first inner race.

Abstract: A bearing arrangement for a turbomachine includes first and second roller element bearings. The first bearing and the second bearing are disposed on opposite axial ends of an intermediate sleeve of the rotating group. The first bearing has a first inner race with a first inner radial surface and a first outer radial surface. The first inner radial surface has a first interference fit with a shaft of the rotating group. The first outer radial surface has a second interference fit with the intermediate sleeve. The second bearing has a second inner race with a second inner radial surface and a second outer radial surface. The second inner race receives the shaft with a clearance fit. The second outer radial surface has a third interference fit with the intermediate sleeve. The second inner race is coaxially aligned with the first inner race and the shaft via coaxial alignment of the intermediate sleeve and the first inner race.

Abstract: An assembly can include a shaft that includes threads and a free end that includes a shaft drive feature; a compressor wheel that includes a compressor wheel drive feature and a through bore that receives the shaft; and a nut that includes threads that mate the threads of the shaft.

Abstract: A method of loading a rotating assembly of a turbocharger can include positioning a swage collar on an end portion of a turbocharger shaft that extends through a through bore of a compressor wheel; applying a pulling force to the end portion of the turbocharger shaft to achieve a desired amount of loading; deforming the swage collar to form a swaged collar fixed to the end portion of the turbocharger shaft; and releasing the pulling force wherein the swaged collar maintains the desired amount of loading.

Abstract: A turbocharger assembly includes a compressor wheel with a base surface, a nose surface, a z-plane disposed between the base surface and the nose surface and a bore extending from the base surface to the nose surface and a shaft that includes a first pilot surface disposed in the bore of the compressor wheel at a position between the z-plane and the nose surface, a second pilot surface disposed in the bore of the compressor wheel at a position between the z-plane and the base surface, and a recessed surface disposed between the first pilot surface and the second pilot surface. A nut adjustably disposed on the shaft adjacent to the nose surface can tension the shaft to apply a compressive load between the base surface and the nose surface of the compressor wheel. Various other examples of devices, assemblies, systems, methods, etc., are also disclosed.

Abstract: An assembly can include a shaft that includes threads and a free end that includes a shaft drive feature; a compressor wheel that includes a compressor wheel drive feature and a through bore that receives the shaft; and a nut that includes threads that mate the threads of the shaft.

Abstract: A method of loading a rotating assembly of a turbocharger can include positioning a swage collar on an end portion of a turbocharger shaft that extends through a through bore of a compressor wheel; applying a pulling force to the end portion of the turbocharger shaft to achieve a desired amount of loading; deforming the swage collar to form a swaged collar fixed to the end portion of the turbocharger shaft; and releasing the pulling force wherein the swaged collar maintains the desired amount of loading.

Abstract: An exemplary semi-floating bearing for a turbocharger has a central axis defining a cylindrical coordinate system with an axial direction, a radial direction and an angular direction; a turbine end; a compressor end; journal surfaces between the turbine end and the compressor end, the surfaces configured to support a turbocharger shaft; and an opening disposed between the turbine end and the compressor end, the opening having a radial dimension that exceeds an axial dimension to, upon receipt of a locating pin, provide for movement of the bearing in the angular direction about its central axis and to provide for lesser movement of the bearing in the axial direction. Other exemplary bearings, arrangements and methods are also disclosed.

Abstract: A turbocharger assembly includes: a housing with a through-bore and a cross-bore that intersects the through-bore to define an upper portion of the cross-bore with a first diameter and a lower portion of the cross-bore with a second diameter where the first diameter exceeds the second diameter; a bearing disposed in the through-bore of the housing where the bearing includes a through-bore configured to support a shaft and a cross-bore that intersects the through-bore; and a locating pin with a diameter that exceeds the second diameter of the lower portion of the cross-bore of the housing, the locating pin press-fit at least partially into the lower portion of the cross-bore of the housing and disposed at least partially in the lower portion of the cross-bore of the bearing to locate the bearing in the through-bore of the housing. Various other examples of devices, assemblies, systems, methods, etc., are also disclosed.

Abstract: An exemplary assembly includes a component of a turbocharger that includes a bore that extends between an inner, exhaust gas side of the component and an outer, ambient side of the component; a shaft that includes a pin portion and a head portion; a sleeve positioned on the pin portion of the shaft; and a bushing positioned over at least part of the sleeve and over at least part of the head portion of the shaft where the bushing seats the shaft and the sleeve in the bore. During operation of a turbocharger that includes such an assembly, the shaft, the sleeve and the bushing restrict flow of exhaust gas from the inner, exhaust gas side of the component to the outer, ambient side of the component. Various other exemplary devices, assemblies, methods, etc., are also disclosed.

Abstract: A turbocharger assembly includes a compressor wheel with a base surface, a nose surface, a z-plane disposed between the base surface and the nose surface and a bore extending from the base surface to the nose surface and a shaft that includes a first pilot surface disposed in the bore of the compressor wheel at a position between the z-plane and the nose surface, a second pilot surface disposed in the bore of the compressor wheel at a position between the z-plane and the base surface, and a recessed surface disposed between the first pilot surface and the second pilot surface. A nut adjustably disposed on the shaft adjacent to the nose surface can tension the shaft to apply a compressive load between the base surface and the nose surface of the compressor wheel. Various other examples of devices, assemblies, systems, methods, etc., are also disclosed.

Abstract: A turbocharger assembly includes: a housing with a through-bore and a cross-bore that intersects the through-bore to define an upper portion of the cross-bore with a first diameter and a lower portion of the cross-bore with a second diameter where the first diameter exceeds the second diameter; a bearing disposed in the through-bore of the housing where the bearing includes a through-bore configured to support a shaft and a cross-bore that intersects the through-bore; and a locating pin with a diameter that exceeds the second diameter of the lower portion of the cross-bore of the housing, the locating pin press-fit at least partially into the lower portion of the cross-bore of the housing and disposed at least partially in the lower portion of the cross-bore of the bearing to locate the bearing in the through-bore of the housing. Various other examples of devices, assemblies, systems, methods, etc., are also disclosed.

Abstract: An exemplary semi-floating bearing for a turbocharger has a central axis defining a cylindrical coordinate system with an axial direction, a radial direction and an angular direction; a turbine end; a compressor end; journal surfaces between the turbine end and the compressor end, the surfaces configured to support a turbocharger shaft; and an opening disposed between the turbine end and the compressor end, the opening having a radial dimension that exceeds an axial dimension to, upon receipt of a locating pin, provide for movement of the bearing in the angular direction about its central axis and to provide for lesser movement of the bearing in the axial direction. Other exemplary bearings, arrangements and methods are also disclosed.

Abstract: An exemplary assembly includes a component of a turbocharger that includes a bore that extends between an inner, exhaust gas side of the component and an outer, ambient side of the component; a shaft that includes a pin portion and a head portion; a sleeve positioned on the pin portion of the shaft; and a bushing positioned over at least part of the sleeve and over at least part of the head portion of the shaft where the bushing seats the shaft and the sleeve in the bore. During operation of a turbocharger that includes such an assembly, the shaft, the sleeve and the bushing restrict flow of exhaust gas from the inner, exhaust gas side of the component to the outer, ambient side of the component. Various other exemplary devices, assemblies, methods, etc., are also disclosed.