Patents by Inventor Gerard F. Costello

Gerard F. Costello has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chemical process for the preparation of 3-alkylated indole
    Patent number: 5280125
    Abstract: A process for the preparation of a 3-alkylated indole, which comprises:a) reacting a N-(2-nitrostyryl) enamine with an alkylating agent to afford an imine salt,b) optionally reacting the imine salt with water to afford a (2-nitrophenyl)acetaldehyde, andc) reacting the imine salt or the (2-nitrophenyl)acetaldehyde with a reducing agent capable of selectively reducing the nitro group, to afford the desired 3-alkylated indole.
    Type: Grant
    Filed: December 4, 1991
    Date of Patent: January 18, 1994
    Assignee: Imperial Chemical Industries PLC
    Inventors: Robert T. Jacobs, Gerard F. Costello, Stephen A. Brook, Peter J. Harrison