Patents by Inventor Gerard Francis Hoyne

Gerard Francis Hoyne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for enhancing T cell reactivity toward tumour antigens
    Patent number: 7678758
    Abstract: Provided is a method of vaccinating a patient against a tumor by administering an agent to reduce or prevent interaction between Notch and a Notch ligand, or expression or processing of Notch or a Notch ligand. In one embodiment, this is accomplished by administering to the patient a tumor antigen expressed by the tumor and exposing an antigen presenting cell in the patient to an agent that reduces or prevents interaction, expression or processing of Notch or a Notch ligand in a T cell.
    Type: Grant
    Filed: May 16, 2002
    Date of Patent: March 16, 2010
    Assignee: Celldex Therapeutics Ltd.
    Inventors: Jonathan Robert Lamb, Gerard Francis Hoyne
  • Notch
    Patent number: 7399741
    Abstract: The present invention relates to the use of therapeutic compounds in the modification of T-cell, T-cell-antigen presenting cell (APC) interactions and the interactions between pathogenic organisms and immunocompetent cells of a host. In particular it relates to the use of these compounds in the modulation of the interaction between Notch proteins and their ligands and to the use of such compounds in the therapy of conditions such as graft rejection, autoimmunity, allergy, and asthma and infectious diseases.
    Type: Grant
    Filed: June 25, 2004
    Date of Patent: July 15, 2008
    Assignee: Celldex Therapeutics Limited
    Inventors: Jonathan Robert Lamb, Margaret Jane Dallman, Gerard Francis Hoyne
  • Notch
    Patent number: 6887475
    Abstract: The present invention relates to the use of therapeutic compounds in the modification of T-cells, T-cell-antigen presenting cell (APC) interactions and the interaction between pathogenic organism and immunocompetent cells of a host. In particular, it relates to the use of these compounds in the modulation of the interaction between Notch proteins and their ligands and to the use of such compounds in the therapy of conditions such as graft rejection, autoimmunity, allergy, asthma and infectious diseases.
    Type: Grant
    Filed: May 4, 1999
    Date of Patent: May 3, 2005
    Assignee: Lorantis Limited
    Inventors: Jonathan Robert Lamb, Margaret Jane Dallman, Gerard Francis Hoyne
  • Notch
    Publication number: 20040241180
    Abstract: The present invention relates to the use of therapeutic compounds in the modification of T-cell, T-cell-antigen presenting cell (APC) interactions and the interactions between pathogenic organisms and immunocompetent cells of a host. In particular it relates to the use of these compounds in the modulation of the interaction between Notch proteins and their ligands and to the use of such compounds in the therapy of conditions such as graft rejection, autoimmunity, allergy, and asthma and infectious diseases.
    Type: Application
    Filed: June 25, 2004
    Publication date: December 2, 2004
    Inventors: Jonathan Robert Lamb, Margaret Jane Dallman, Gerard Francis Hoyne
  • Hedgehog
    Publication number: 20040126359
    Abstract: Provided is a method of modulating T-cell activation, proliferation or apoptosis by contacting T-cells with a modulator of a Hedgehog signalling pathway or a modulator of a pathway which is a target of the Hedgehog signaling pathway.
    Type: Application
    Filed: October 9, 2003
    Publication date: July 1, 2004
    Inventors: Jonathan Robert Lamb, Gerard Francis Hoyne, Margaret Jane Dallman, Brian Robert Champion
  • Assay
    Publication number: 20040005631
    Abstract: A method for monitoring the immune system comprising monitoring the Notch signalling pathway.
    Type: Application
    Filed: February 3, 2003
    Publication date: January 8, 2004
    Inventors: Jonathan Robert Lamb, Gerard Francis Hoyne, Margaret Jane Dallman, Brian Robert Champion
  • Immunotherapy
    Publication number: 20030194804
    Abstract: A method is provided for enhancing the reactivity of a T cell toward a tumour cell which method comprises:
    Type: Application
    Filed: May 16, 2002
    Publication date: October 16, 2003
    Inventors: Jonathan Robert Lamb, Gerard Francis Hoyne
  • Therapeutic use
    Publication number: 20020192216
    Abstract: Use of an inhibitor of a Hedgehog signalling pathway, or an inhibitor of a pathway which is a target of the Hedgehog signalling pathway in the preparation of a medicament for treatment of epithelial cell hyperplasia, fibrosis of tissue, inflammation, cancer or an immune disorder.
    Type: Application
    Filed: December 7, 2001
    Publication date: December 19, 2002
    Inventors: Jonathan Robert Lamb, Gerard Francis Hoyne, Margaret Jane Dallman
  • Methods of immunosuppression
    Publication number: 20010048930
    Abstract: A method for producing a T cell having tolerance to an allergen or antigen which method comprises incubating the T cell with an antigen presenting cell (APC) in the presence of (i) a composition capable of upregulating expression of an endogenous Notch ligand in the APC and (ii) the allergen or antigen is provided.
    Type: Application
    Filed: May 31, 2001
    Publication date: December 6, 2001
    Inventors: Jonathan Robert Lamb, Margaret Jane Dallman, Gerard Francis Hoyne