Abstract: Among the various aspects of the present disclosure is the provision of methods of diagnosing and treating inflammatory bowel disease (IBD) including ulcerative colitis (UC) or Crohn's disease (CD). In particular, the present disclosure provides in part a panel of IBD biomarkers useful in diagnosing and making treatment decisions. In addition, the present disclosure provides methods of treating IBD with a plasminogen activator inhibitor-1 (PAI-1) inhibitor or tissue plasminogen activator (tPA).

Abstract: A safety system (105) for an elevator system (100) which includes a hoistway (104), an elevator car (102) and a plurality of landing doors (112a-f). The safety system (105) includes a first safety chain (120), a second safety chain (125) and a controller (110). The first safety chain (120) is configured to produce an even landing signal and the second safety chain (125) is configured to produce an odd landing signal. The controller (110) is configured to automatically instruct the elevator system (100) to enter a special operating mode when the production of the even landing signal and the odd landing signal indicates that the elevator car (102) is located at an even landing and an odd landing door is open, or that the elevator car (102) is located at an odd landing and an even landing door is open.

Abstract: The disclosure relates to a fiber-reinforced thermoplastic composite, in particular to a fiber-reinforced polyamide tape. Furthermore, the disclosure further relates to a method of preparing said fiber-reinforced thermoplastic composite and to articles, in particular laminates, made of the thermoplastic polymer fiber-reinforced thermoplastic composite of the disclosure.

Abstract: A cushion assembly for a patient interface including an elastomeric seal-forming structure that is shaped to be bisected by a sagittal plane having a line that is tangent to the elastomeric seal-forming structure at a superior tangent point and at an inferior tangent point. A saddle-shaped superior region of the elastomeric seal-forming structure straddles the sagittal plane and includes the superior tangent point. The elastomeric seal-forming structure transitions in a cylinder-shaped superior region from the saddle-shaped region to a dome-shaped superior region offset from the sagittal plane. In addition, an elastomeric wall thickness of the elastomeric seal-forming structure is greater in the cylinder-shaped superior region than in the saddle-shaped superior region and the dome-shaped superior region.

Abstract: A safety system (105) for an elevator system (100). The safety system (105) includes a plurality of sensors (120) and a controller (110). Each of the plurality of sensors (120) is configured to produce an override signal when a landing door (112a) to which the sensor is connected is opened by manual override. The controller (110) is configured to instruct the elevator system (100) to automatically enter a special operating mode when the override signal is received from one of the plurality of sensors (120).

Abstract: The invention relates to novel crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-(.beta.-L-ribofuranosyl)-1H-benzimidazo-le (Maribavir), pharmaceutical compositions thereof and their use in medical therapy.

Abstract: A machine vision system includes a vision components portion and an inspection portion. The inspection portion includes a variable focal length (VFL) lens, a VFL lens controller, an inspection portion light source, an inspection portion objective lens, and an inspection portion camera. The vision components portion performs an autofocus process which indicates z-heights of a plurality of sampling points on a surface of a workpiece for determining coarse surface profile data. The inspection portion thereafter performs an inspection process, which comprises acquiring an extended depth of field (EDOF) image for each inspection point of a plurality of inspection points on the surface of the workpiece, and for which an inspection scan path is followed which includes adjustments in relation to the distance between the inspection portion and the surface of the workpiece and is determined based at least in part on the coarse surface profile data from the autofocus process.

Abstract: Methods and compositions for treating multiple sclerosis using dendritic cell anti-ASGPR antibodies fused to myelin basic protein or myelin oligodendrocyte glycoprotein are provided.

Abstract: Methods and systems for determining random variation in one or more structures on a specimen are provided. One method includes determining characteristic(s) of output generated by an output acquisition subsystem for structure(s) formed on a specimen and simulating the characteristic(s) of the output with initial parameter values for the structure(s). The method also includes determining parameter values of the structure(s) formed on the specimen as the initial parameter values that resulted in the simulated characteristic(s) that best match the determined characteristic(s). The determined parameter values are responsive to random variation in parameter(s) of the structure(s) on the specimen.

Abstract: A cushion assembly for a patient interface includes a foam cushion and an elastomeric support portion configured to support the foam cushion. The foam cushion is more compliant in a nasal bridge region than other regions of the cushion assembly, the nasal bridge region being a region configured to engage the patient's nasal bridge when the cushion assembly is mounted on the patient's face.

Abstract: A composition and method for using the composition in the fabrication of an electronic device are disclosed. Compounds, compositions and methods for depositing a low dielectric constant (<4.0) and high oxygen ash resistance silicon-containing film such as, without limitation, a carbon doped silicon oxide, are disclosed.

Abstract: An inspection system includes sensors that are selectively coupled to a vehicle during an inspection and/or maintenance event for the vehicle and a controller that is operable to cause a control system of the vehicle to initiate a first operation and a different, second operation. The controller determines whether first sensor information indicative of a state of the vehicle during the first operation exists. The controller sends a command signal to the control system to direct the control system to change vehicle operations from the first operation to the second operation responsive to determining that the first sensor information is lacking. The controller obtains second sensor information from the sensors based on the second operation and determines a condition of the vehicle based on the first and/or second sensor information.

Abstract: The present invention relates to a novel analytical method for detecting one or more analytes in a source sample by continuous flow 2D LC-MS/MS using a single LC system.

Abstract: A food and/or drink container includes an enclosure forming a space configured to receive a food and/or drink, a display coupled to the enclosure, and a processor communicatively coupled to the display. The processor is configured to receive an indication of a current location of the food and/or drink container and cause the display to output imagery based on the current location.

Abstract: A mesh element having a mesh gauge selected to control flow of materials therethrough. The mesh element is implantable into an anatomical structure upstream of a body passage or within a body passage to control flow of materials through the body passage. The mesh element may be coupled to a support structure to facilitate anchoring of the mesh element in place relative to the body passage. The support structure may have a lumen defined therethrough to allow flow of materials through the body passage, with the mesh element regulating the flow of materials into the lumen. The mesh element alternatively may be directly coupled to an anatomical structure upstream of a body passage to regulate or determine flow of materials through the body passage.

Abstract: A helmet assembly including a helmet shell having a face opening, first and second chin projections, an outer surface an inner surface, and a faceguard. The face opening is at least partially defined by a forehead edge. At least a first tunnel member is disposed on the inner surface adjacent the forehead edge. First and second receiving members are disposed on the inner surface on the first and second chin projections, respectively. The faceguard includes upper and lower sections. The upper section includes at least a first prong member extending upwardly therefrom that is removably received in a secured position in the first tunnel member. The lower section includes first and second wing members extending therefrom that are removably received in a secured position in the first and second receiving members, respectively.

Abstract: Methods of treating propionic acidemia (PA), methylmalonic acidemia (MMA) and fatty acid oxidation disorders are described. The methods include administering an anaplerotic agent that can directly enter the tricarboxylic acid cycle, such as a succinate derivative or pro-drug, for example trisuccinylglycerol (TSG). Methods of restoring tricarboxylic acid (TCA) cycle function in a cell deficient for propionyl-CoA carboxylase (PCC) or methylmalonyl-CoA mutase (MUT) by contacting the cell with a succinate derivative or pro-drug, such as TSG, are also described.

Abstract: Systems, methods, and apparatus for data analytics for a sports activity are disclosed. A multiplicity of sensors tracks a multiplicity of world objects related to the sports activity, collects and communicates tracking data to a server platform in real time or near real time. The server platform integrates the tracking data from the multiplicity of sensors and scoring data for the sports activity, and correlates the tracking data and the scoring data with a corresponding UTC timecode based on rules related to the sports activity, thereby creating a multiplicity of UTC-coded data sets. The server platform synchronizes the multiplicity of UTC-coded data sets, thereby creating a time-synchronized data set. The server platform provides analytics based on the time-synchronized data set, thereby creating analyzed data. The multiplicity of user devices displays the analyzed data based on at least one application program.

Abstract: A processor can include various processing pipelines that perform different data processing operations, with different pipelines having dedicated logic and memory circuits. A power management circuit can determine when to supply power to various pipelines, including the logic and memory circuits of the various pipelines, depending on a current operating mode of the processor. When a memory circuit transitions to a lower power state such as a sleep state, data can be saved to a different memory circuit that is not transitioning to a lower power state, and when the memory circuit is powered up again, the data can be restored from the different memory circuit.