Patents by Inventor Gerard Hugh Thomas

Gerard Hugh Thomas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterocyclic derivatives as GPCR receptor agonists
    Patent number: 8207147
    Abstract: Compounds of Formula (I), R1-A-V—B—R2; or pharmaceutically acceptable salts thereof, are agonists of GPR116 and are useful as regulators of satiety, e.g. for the treatment of obesity, and for the treatment of diabetes.
    Type: Grant
    Filed: December 23, 2004
    Date of Patent: June 26, 2012
    Assignee: Prosidion Limited
    Inventors: Matthew Colin Thor Fyfe, Lisa Sarah Gardner, John King-Underwood, Martin James Procter, Chrystelle Marie Rasamison, Karen Lesley Schofield, Gerard Hugh Thomas
  • G-protein coupled receptor agonists
    Patent number: 8193359
    Abstract: Compounds of Formula (I) or pharmaceutically acceptable salts or N-oxides thereof, are agonists of GPR116 and are useful for the treatment of obesity, and for the treatment of diabetes.
    Type: Grant
    Filed: December 23, 2005
    Date of Patent: June 5, 2012
    Assignee: Prosidion Limited
    Inventors: Matthew Colin Thor Fyfe, Gerard Hugh Thomas, Lisa Sarah Bertram, Stuart Edward Bradley, William Gattrell, Chrystelle Marie Rasamison, Vilasben Kanji Shah
  • Pyridine, pyrimidine and pyrazine derivatives as GPCR agonists
    Patent number: 8173807
    Abstract: Compounds of formula (I): R1-A-V—B—R2, wherein V is phenyl or a 6-membered heteroaryl ring containing up to three N-atoms, or pharmaceutically acceptable salts thereof, are agonists of GPR116 and are useful for the treatment of obesity, and for the treatment of diabetes.
    Type: Grant
    Filed: December 30, 2005
    Date of Patent: May 8, 2012
    Assignee: Prosidion Limited
    Inventors: Stuart Edward Bradley, Matthew Colin Thor Fyfe, Gerard Hugh Thomas
  • Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase
    Patent number: 8158622
    Abstract: Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.
    Type: Grant
    Filed: July 2, 2008
    Date of Patent: April 17, 2012
    Assignee: Prosidion Limited
    Inventors: Stuart Edward Bradley, Thomas Martin Krulle, Peter John Murray, Martin James Procter, Robert John Rowley, Colin Peter Sambrook Smith, Gerard Hugh Thomas, Karen Lesley Schofield
  • Indole-2-carboxylic acid amides
    Publication number: 20110086885
    Abstract: Compounds represented by Formula (I) or pharmaceutically acceptable salts thereof, are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.
    Type: Application
    Filed: November 25, 2005
    Publication date: April 14, 2011
    Inventors: Stuart Edward Bradley, Thomas Martin Krulle, Gerard Hugh Thomas
  • Pyrrolopyridine-2-carboxylic acid hydrazides
    Patent number: 7884112
    Abstract: Compounds of Formula (I) or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, or as cardioprotectants or inhibitors of abnormal cell growth.
    Type: Grant
    Filed: November 5, 2007
    Date of Patent: February 8, 2011
    Inventors: Stuart Edward Bradley, Revathy Perpetua Jeevaratnam, Thomas Martin Krulle, Martin James Procter, Robert John Rowley, Gerard Hugh Thomas, Ana Valdesabril
  • Pyridine, pyrimidine and pyrazine derivatives as gpcr agonists
    Publication number: 20100035897
    Abstract: Compounds of formula (I): R1-A-V—B—R2, wherein V is phenyl or a 6-membered heteroaryl ring containing up to three N-atoms, or pharmaceutically acceptable salts thereof, are agonists of GPR116 and are useful for the treatment of obesity, and for the treatment of diabetes.
    Type: Application
    Filed: December 30, 2005
    Publication date: February 11, 2010
    Inventors: Stuart Edward Bradley, Matthew Colin Thor Fyfe, Gerard Hugh Thomas
  • Treatment of Diabetes with Glycogen Phosphorylase Inhibitors
    Publication number: 20090298745
    Abstract: The invention provides a method of treatment of diabetes, particularly type II diabetes, or a diabetes related condition, comprising night time dosing of an inhibitor of glycogen phosphorylase, optionally in combination another anti-diabetic therapy.
    Type: Application
    Filed: December 2, 2005
    Publication date: December 3, 2009
    Inventors: Gerard Hugh Thomas, Mikael Thomsen
  • HETEROCYCLIC DERIVATIVES AS GPCR RECEPTOR AGONISTS
    Publication number: 20090281060
    Abstract: Compounds of Formula (I), R1-A-V—B—R2; or pharmaceutically acceptable salts thereof, are agonists of GPR116 and are useful as regulators of satiety, e.g. for the treatment of obesity, and for the treatment of diabetes.
    Type: Application
    Filed: December 23, 2004
    Publication date: November 12, 2009
    Applicant: PROSIDION LIMITED
    Inventors: Matthew Fyfe, John King-Underwood, Lisa Sarah Bertram (Gardner), Gerard Hugh Thomas, Martin Procter, Chrystelle Rasamison, Karen Schofield
  • Gpcr Agonists
    Publication number: 20090221644
    Abstract: Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.
    Type: Application
    Filed: June 29, 2006
    Publication date: September 3, 2009
    Inventors: Stuart Edward Bradley, Matthew Colin Thor Fyfe, Lisa Sarah Bertram, William Gattrell, Martin James Procter, Chrystelle Marie Rasamison, Colin Peter Sambrook-Smith, Vilasben Kanji Shah, David French Stonehouse, Simon Andrew Swain, Gerard Hugh Thomas
  • Dihydroimidazothiazole Derivatives
    Publication number: 20090221645
    Abstract: Compounds of formula (I) or pharmaceutically acceptable salts thereof, exhibit 5-HT1A agonism in addition to noradrenaline reuptake inhibition and optionally also 5-HT reuptake inhibition are useful for the treatment of obesity.
    Type: Application
    Filed: February 8, 2006
    Publication date: September 3, 2009
    Inventors: Oscar Barba, Graham John Dawson, Thomas Martin Krulle, Robert John Rowley, Donald Smyth, Gerard Hugh Thomas
  • G-Protein Coupled Receptor Agonists
    Publication number: 20090099227
    Abstract: Compounds of Formula (I) or pharmaceutically acceptable salts or N-oxides thereof, are agonists of GPR116 and are useful for the treatment of obesity, and for the treatment of diabetes.
    Type: Application
    Filed: December 23, 2005
    Publication date: April 16, 2009
    Inventors: Matthew Colin Thor Fyfe, Gerard Hugh Thomas, Lisa Sarah Bertram, Stuart Edward Bradley, William Gattrell, Chrystelle Marie Rasamison, Vilasben Kanji Shah
  • PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDES
    Publication number: 20090099176
    Abstract: Compounds represented by Formula (I) or pharmaceutically acceptable salts thereof, are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.
    Type: Application
    Filed: December 2, 2005
    Publication date: April 16, 2009
    Inventors: Thomas Martin Krulle, Robert John Rowley, Gerard Hugh Thomas
  • Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase
    Publication number: 20090023703
    Abstract: Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.
    Type: Application
    Filed: July 2, 2008
    Publication date: January 22, 2009
    Inventors: Stuart Edward Bradley, Thomas Martin Krulle, Peter John Murray, Martin James Procter, Robert John Rowley, Colin Peter Sambrook Smith, Gerard Hugh Thomas
  • G-Protein Coupled Receptor (Gpr116) Agonists and Use Thereof for Treating Obesity and Diabetes
    Publication number: 20080312281
    Abstract: Compounds of formula (I), or pharmaceutically acceptable salts thereof, are agonists of GPR116 and are useful for the treatment of obesity, and for the treatment of diabetes.
    Type: Application
    Filed: December 23, 2005
    Publication date: December 18, 2008
    Inventors: Matthew Colin Thor Fyfe, Lisa Sarah Bertram, Gerard Hugh Thomas, Geoffrey Martyn Williams
  • Pyrrolopyridine-2-Carboxylic Acid Hydrazides
    Publication number: 20080269277
    Abstract: Compounds of Formula (I) or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, or as cardioprotectants or inhibitors of abnormal cell growth.
    Type: Application
    Filed: March 8, 2005
    Publication date: October 30, 2008
    Inventors: Stuart Edward Bradley, Revathy Perpetua Jeevaratnam, Thomas Martin Krulle, Martin James Procter, Robert John Rowley, Gerard Hugh Thomas, Ana Valdes
  • Indole-2-Carboxylic Acid Hydrazides
    Publication number: 20080188472
    Abstract: Compounds of formula (I) or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia, e.g. myocardial ischemia, or as cardioprotectants or inhibitors of abnormal cell growth.
    Type: Application
    Filed: March 8, 2005
    Publication date: August 7, 2008
    Applicant: PROSIDION LIMITED
    Inventors: Stuart Edward Bradley, Revathy Perpetua Jeevaratnam, Thomas Martin Krulle, Martin James Procter, Robert John Rowley, Gerard Hugh Thomas, Ana Valdes
  • Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase
    Patent number: 7405210
    Abstract: Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.
    Type: Grant
    Filed: May 20, 2004
    Date of Patent: July 29, 2008
    Assignee: OSI Pharmaceuticals, Inc.
    Inventors: Stuart Edward Bradley, Thomas Martin Krulle, Peter John Murray, Martin James Procter, Robert John Rowley, Colin Peter Sambrook Smith, Gerard Hugh Thomas