Patents by Inventor Gerard J. Nau

Gerard J. Nau has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RNA SEQUENCING TO DIAGNOSE SEPSIS AND OTHER DISEASES AND CONDITIONS
    Publication number: 20220340972
    Abstract: Deep RNA sequencing is a technology that provides an initial diagnostic for sepsis that can also monitor the indicia of treatment and recovery (bacterial counts reduce, physiology returns to steady-state). The invention can be used for many other hospital conditions, particularly those needing an intensive care unit stay with the attendant risk of bacterial infection, such as trauma, stroke, myocardial infarction, or major surgery.
    Type: Application
    Filed: April 18, 2022
    Publication date: October 27, 2022
    Inventors: Sean F. MONAGHAN, Gerard J. NAU, Alger M. FREDERICKS
  • USE OF RESAZURIN, OR ANALOGS THEREOF, FOR ANTIBACTERIAL THERAPY
    Publication number: 20150258103
    Abstract: A method for treating infection by bacteria in a subject, comprising administering to the subject a therapeutically effective amount of resazurin or a resazurin analog, or a pharmaceutically acceptable salt or ester thereof, wherein the bacteria is selected from at least one of Francisella sp. or Neisseria sp.
    Type: Application
    Filed: October 29, 2013
    Publication date: September 17, 2015
    Applicant: University of Pittsburgh - Of the Commonweath System of Higher Education
    Inventors: Joseph A. HORZEMPA, Dawn M. HENSON, Gerard J. NAU
  • Photosensitizer conjugates for targeting intracellular pathogens
    Patent number: 6977075
    Abstract: The methods of the invention can be used to treat mycobacterial infections, or any disease or disorder that is caused by (or aggravated by) an intracellular pathogen. Accordingly, the invention features methods for treating a subject who has a disorder that is associated with an intracellular pathogen by administering, to a subject, a molecular conjugate that includes a photosensitizer (a term used herein to refer to a light activatable compound) and a targeting moiety, the targeting moiety being capable of targeting the conjugate to the intracellular pathogen.
    Type: Grant
    Filed: April 14, 2003
    Date of Patent: December 20, 2005
    Assignee: The General Hospital Corporation
    Inventors: Tayyaba Hasan, Jerome Gross, Gerard J. Nau
  • Diagnostic and therapeutic applications for biomarkers of infection
    Publication number: 20040038201
    Abstract: Distinct gene expression programs activated in response to different pathogens in macrophages are disclosed. Methods of diagnosis and treatment are also disclosed.
    Type: Application
    Filed: January 22, 2003
    Publication date: February 26, 2004
    Applicant: Whitehead Institute for Biomedical Research
    Inventors: Gerard J. Nau, John F. L. Richmond
  • Photosensitizer conjugates for targeting intracellular pathogens
    Publication number: 20030224002
    Abstract: The methods of the invention can be used to treat mycobacterial infections, or any disease or disorder that is caused by (or aggravated by) an intracellular pathogen. Accordingly, the invention features methods for treating a subject who has a disorder that is associated with an intracellular pathogen by administering, to a subject, a molecular conjugate that includes a photosensitizer (a term used herein to refer to a light activatable compound) and a targeting moiety, the targeting moiety being capable of targeting the conjugate to the intracellular pathogen.
    Type: Application
    Filed: April 14, 2003
    Publication date: December 4, 2003
    Inventors: Tayyaba Hasan, Jerome Gross, Gerard J. Nau
  • Photosensitzer conjugates for targeting intracellular pathogens
    Patent number: 6610298
    Abstract: The methods of the invention can be used to treat mycobacterial infections, or any disease or disorder that is caused by (or aggravated by) an intracellular pathogen. Accordingly, the invention features methods for treating a subject who has a disorder that is associated with an intracellular pathogen by administering, to a subject, a molecular conjugate that includes a photosensitizer (a term used herein to refer to a light activatable compound) and a targeting moiety, the targeting moiety being capable of targeting the conjugate to the intracellular pathogen.
    Type: Grant
    Filed: October 15, 1999
    Date of Patent: August 26, 2003
    Assignee: The General Hospital Corporation
    Inventors: Tayyaba Hasan, Jerome Gross, Gerard J. Nau
  • PHOTOSENSITZER CONJUGATES FOR TARGETING INTRACELLULAR PATHOGENS
    Publication number: 20020122805
    Abstract: The methods of the invention can be used to treat mycobacterial infections, or any disease or disorder that is caused by (or aggravated by) an intracellular pathogen. Accordingly, the invention features methods for treating a subject who has a disorder that is associated with an intracellular pathogen by administering, to a subject, a molecular conjugate that includes a photosensitizer (a term used herein to refer to a light activatable compound) and a targeting moiety, the targeting moiety being capable of targeting the conjugate to the intracellular pathogen.
    Type: Application
    Filed: October 15, 1999
    Publication date: September 5, 2002
    Inventors: TAYYABA HASAN, JEROME GROSS, GERARD J NAU