Abstract: A method of predicting a composition of a meal includes obtaining data relating to concentration of a biomarker of an individual that consumed the meal, analyzing the data to determine the composition of the meal, wherein the analyzing comprises using a computational model. The computational model relies upon statistical learning techniques to breakdown meal composition into macronutrient levels.

Abstract: In an embodiment, the present disclosure pertains to an analyte detection system. In some embodiments, the system includes a biosensor operable to be implanted into a media and a transmitter having a light source. In some embodiments, the transmitter is operable to be external to the media and operable to receive photoluminescence outputs back from the biosensor to determine properties of an analyte. In an additional embodiment, the present disclosure pertains to an analyte detection system. In some embodiments, the system includes a biosensor operable to be implanted into a media and a transmitter having a light source. In some embodiments, the transmitter is operable to be external to the media and operable to receive photoluminescence outputs back from the biosensor to determine properties of analytes. In a further embodiment, the present disclosure pertains to a biosensor having a plurality of discrete compartments in a barcode configuration.

Abstract: Embodiments of the present disclosure pertain to a sensor that includes a transduction agent, a plurality of analyte binding agents immobilized on the transduction agent, and a coating agent that forms a coating around at least some of the analyte binding agents. Further embodiments of the present disclosure pertain to methods of detecting one or more analytes in a sample by associating the sample with a sensor of the present disclosure; detecting a signal from the sensor; and correlating the signal to the presence or absence of the one or more analytes in the sample. Additional embodiments of the present disclosure pertain to methods of making the sensors of the present disclosure by immobilizing a plurality of analyte binding agents on a transduction agent; and coating at least some of the analyte binding agents with a coating agent to form a sensor.

Abstract: In an embodiment, the present disclosure pertains to a microfluidic device composed of a substrate having an inlet region and a first storage region, a fluid transporting channel in fluid communication with the inlet region, an expandable component in fluid communication with the fluid transporting channel and coupled to a movable arm, and a fluid transporting region coupled to the movable arm and operable to be moved in a horizontal direction to the fluid transporting channel to thereby form fluidic contact between the inlet region and the first storage region upon expansion of the expandable component. In an additional embodiment, the present disclosure pertains to a method of fluid flow utilizing a microfluidic device of the present disclosure.

Abstract: A method of predicting a composition of a meal includes obtaining data relating to concentration of a biomarker of an individual that consumed the meal, analyzing the data to determine the composition of the meal, wherein the analyzing comprises using a computational model. The computational model relies upon statistical learning techniques to breakdown meal composition into macronutrient levels.

Abstract: There is a need in the point-of-care diagnostic community for an efficient and portable method for testing blood and other biological fluids that can be easily translated across multiple applications. An aspect of the invention described involves monitoring the optical properties of molecularly-mediated nanoparticle assemblies though an optically transparent and magnetically active microfluidic chip, which has recently emerged as an attractive method for biomarker detection as it is an efficient tool for monitoring the binding events that take place in a sensing assay. In one embodiment, this device is directed towards two-nanoparticle assays that rely on the assembly or disassembly of plasmonic and magnetic nanoparticles in response to a certain analyte. A further embodiment is directed to a spiral microfluidic using inertial forces to filter fluid components by size, connected to a magnetically active channel comprised of a nickel micropad array, optically transparent microchannel, and permanent magnets.

Abstract: Embodiments of the invention are directed to biosensors comprising one or more encapsulated functionalized domains, where the encapsulating matrix acts as the primary interface between the biosensor and the environment. Embodiments of the invention are directed to the fabrication of the biosensor.

Abstract: There is a need in the point-of-care diagnostic community for an efficient and portable method for testing blood and other biological fluids that can be easily translated across multiple applications. An aspect of the invention described involves monitoring the optical properties of molecularly-mediated nanoparticle assemblies though an optically transparent and magnetically active microfluidic chip, which has recently emerged as an attractive method for biomarker detection as it is an efficient tool for monitoring the binding events that take place in a sensing assay. In one embodiment, this device is directed towards two-nanoparticle assays that rely on the assembly or disassembly of plasmonic and magnetic nanoparticles in response to a certain analyte. A further embodiment is directed to a spiral microfluidic using inertial forces to filter fluid components by size, connected to a magnetically active channel comprised of a nickel micropad array, optically transparent microchannel, and permanent magnets.

Abstract: There is a need in the point-of-care diagnostic community for an efficient and portable method for testing blood and other biological fluids that can be easily translated across multiple applications. An aspect of the invention described involves monitoring the optical properties of molecularly-mediated nanoparticle assemblies though an optically transparent and magnetically active microfluidic chip, which has recently emerged as an attractive method for biomarker detection as it is an efficient tool for monitoring the binding events that take place in a sensing assay. In one embodiment, this device is directed towards two-nanoparticle assays that rely on the assembly or disassembly of plasmonic and magnetic nanoparticles in response to a certain analyte. A further embodiment is directed to a spiral microfluidic using inertial forces to filter fluid components by size, connected to a magnetically active channel comprised of a nickel micropad array, optically transparent microchannel, and permanent magnets.

Abstract: There is a need in the point-of-care diagnostic community for an efficient and portable method for testing blood and other biological fluids that can be easily translated across multiple applications. An aspect of the invention described involves monitoring the optical properties of molecularly-mediated nanoparticle assemblies though an optically transparent and magnetically active microfluidic chip, which has recently emerged as an attractive method for biomarker detection as it is an efficient tool for monitoring the binding events that take place in a sensing assay. In one embodiment, this device is directed towards two-nanoparticle assays that rely on the assembly or disassembly of plasmonic and magnetic nanoparticles in response to a certain analyte. A further embodiment is directed to a spiral microfluidic using inertial forces to filter fluid components by size, connected to a magnetically active channel comprised of a nickel micropad array, optically transparent microchannel, and permanent magnets.

Abstract: Methods and apparatuses for an oxygen consumption monitoring system are disclosed herein. In one embodiment, an oxygen consumption monitoring system is disclosed. The oxygen consumption monitoring system may comprise a probe, wherein the probe comprises a light source and a photodetector; and a main unit, wherein the main unit comprises a microcontroller and wireless transmitter. The probe may be hermetically sealed and may be capable of being implanted onto tissue. The photodetector may be capable of collecting reflectance data from the light emitted by the light source. The reflectance data may be capable of being sorted into arterial and venous blood oxygen consumption data for the tissue onto which the probe was placed or implanted. The data from the probe may be further sorted and processed to produce perfusion, heart rate, energy expenditure, caloric burn, blood pressure, hemoglobin concentration changes, and tissue oxidative stress.

Abstract: Methods and apparatuses for a tissue mechanical property monitoring system are disclosed herein. In one embodiment, a tissue mechanical property monitoring system is disclosed. The tissue mechanical property monitoring system may comprise a probe, wherein the probe comprises a light source and a photodetector; and a main unit, wherein the main unit comprises a microcontroller and wireless transmitter. The probe may be hermetically sealed and may be capable of being implanted onto tissue. The photodetector may be capable of collecting reflectance data from the light emitted by the light source. The reflectance data may be capable of being sorted and processed into tissue mechanical property data such as tissue compliance, vascular resistance, and the like for the tissue illuminated with the probe.

Abstract: The disclosure provides a ligand that competes with glucose for binding the protein Concanavalin A (ConA) and competitive binding assays incorporating the ligand. The competing ligand binds to the primary and part or all of the extended binding sites of Concanavalin A. These and other aspects of the disclosure are useful for glucose monitoring (e.g., continuous glucose monitoring (CGM)).

Abstract: There are many inventions described and illustrated herein. In one aspect, the present invention is a system and technique for non-invasively measuring, monitoring, inspecting, characterizing, determining and/or evaluating the blood glucose level in the aqueous humor of the eye of a patient (for example, a diabetic). In one embodiment, the present invention employs a plurality of wavelengths of light (for example, more than three) to measure, monitor, characterize, determine and/or evaluate the blood glucose level or concentration of a patient. The plurality of wavelengths of light may be directed into the aqueous humor of the eye and the reflected light (i.e., the light reflected by the eye) is detected and analyzed to provide information which is representative of the blood glucose level or concentration of the patient.

Abstract: Provided are a variety of chemically sensitive, stable (insoluble over a specified period of time), nontoxic, and non-antigenic hydrogel particles which undergo a measurable change in at least one electrochemical or optical property as a function of interaction with one or more substance(s) to be detected. Also provided are methods of using these hydrogel particles to detect one or more selected analytes, and in certain aspects detect one or more analytes in vivo. Further provided are devices used to detect and measure the optical or electrochemical changes.