Patents by Inventor Gerard M. Koether

Gerard M. Koether has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alkyl sulfoxide quinolines as NK-3 receptor ligands
    Patent number: 7964733
    Abstract: Compounds of Formula I wherein R1, A, R2, R3, R4, R5, n, m and q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
    Type: Grant
    Filed: September 19, 2006
    Date of Patent: June 21, 2011
    Assignee: AstraZeneca AB
    Inventors: Jeffrey S. Albert, Gerard M. Koether, Cristobal Alhambra, James Kang, Thomas R. Simpson, James Woods, Yan Li
  • Substituted Amino-Compounds and Uses Thereof
    Publication number: 20090221579
    Abstract: This invention relates to novel compounds having the structural formula Ia or formula Ib: Ia Ib and their pharmaceutically acceptable salts, tautomers or in vivo hydrolysable precursors, compositions and methods of use thereof. These novel compounds provide a treatment or prophylaxis of A? related pathologies such as cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.
    Type: Application
    Filed: October 14, 2005
    Publication date: September 3, 2009
    Inventors: Jeffrey Scott Albert, Don Andisik, James Arnold, Dean Brown, Owen Callaghan, James Campbell, Robin Arthur Ellis Carr, Gianni Chessari, Miles Stuart Congreve, Phil Edwards, James R. Empfield, Martyn Frederickson, Gerard M. Koether, Jennifer Krumrine, Russ Mauger, Christopher William Murray, Sahil Patel, Mark Sylvester, Scott Throner
  • Substituted Amino-Pyrimidones and Uses Thereof
    Publication number: 20090062282
    Abstract: This invention relates to novel compounds having the structural formula Ia or formula Ib below: (Ia, Ib), and their pharmaceutically acceptable salts, tautomers or in vivo hydrolysable precursors, compositions and methods of use thereof. These novel compounds provide a treatment or prophylaxis of A? related pathologies such as cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.
    Type: Application
    Filed: October 14, 2005
    Publication date: March 5, 2009
    Applicant: AstraZeneca AB
    Inventors: Jeffrey Scott Albert, Don Andisik, James Arnold, Dean Brown, Owen Callaghan, James Campbell, Robin Arthur Ellis Carr, Gianni Chessari, Miles Stuart Congreve, Phil Edwards, James R. Empfield, Martyn Frederickson, Gerard M. Koether, Jennifer Krumrine, Russ Mauger, Christopher William Murray, Sahil Patel, Mark Sylvester, Scott Throner
  • Alkylnitrile Quinolines as Nk-3 Receptor Ligands
    Publication number: 20080306110
    Abstract: Compounds of Formula I wherein R1, A, R2, R3, R4, R5, n, m and q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
    Type: Application
    Filed: September 19, 2006
    Publication date: December 11, 2008
    Applicant: ASTRAZENECA AB
    Inventors: Jeffrey S. Albert, Cristobal Alhambra, James Kang, Gerard M. Koether, Thomas R. Simpson, James Woods, Yan Li
  • Alkylpyridyl Quinolines as Nk3 Receptor Modulators
    Publication number: 20080287492
    Abstract: Compounds of Formula I wherein R1, A, R2, R3, R4, R5, n, m and p are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
    Type: Application
    Filed: August 9, 2006
    Publication date: November 20, 2008
    Applicant: AstraZeneca AB
    Inventors: Jeffrey S. Albert, Cristobal Alhambra, James Kang, Gerard M. Koether, Thomas R. Simpson, James Woods, Yan Li
  • Oxopyridyl Quinoline Amides as Nk3 Receptor Modulators
    Publication number: 20080280949
    Abstract: Compounds of Formula I wherein R1, A, R2, R3, R4, R5, n, m and q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
    Type: Application
    Filed: August 10, 2006
    Publication date: November 13, 2008
    Applicant: AstraZeneca AB
    Inventors: Jeffrey S. Albert, Cristobal Alhambra, James Kang, Gerard M. Koether, Thomas R. Simpson, James Woods, Yan Li
  • N-Oxo-Heterocycle and N-Oxo-Alkyl Quinoline-4-Carboxamides as Nk-3 Receptor Ligands
    Publication number: 20080234269
    Abstract: Compounds of Formula I wherein R1, A, R2, R3, R4, R5, n, m and q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
    Type: Application
    Filed: September 19, 2006
    Publication date: September 25, 2008
    Applicant: ASTRAZENECA AB
    Inventors: James B. Campbell, Jeffrey S. Albert, Cristobal Alhambra, James Kang, Gerard M. Koether, Thomas R. Simpson, James Woods, Yan Li
  • Alkyl Sulfoxide Quinolines as Nk-3 Receptor Ligands
    Publication number: 20080214605
    Abstract: Compounds of Formula I wherein R1, A, R2, R3, R4, R5, n, m and q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
    Type: Application
    Filed: September 19, 2006
    Publication date: September 4, 2008
    Applicant: AstraZeneca AB
    Inventors: Jeffrey S. Albert, Gerard M. Koether, Cristobal Alhambra, James Kang, Thomas R. Simpson, James Woods, Yan Li
  • Amide Alkyl Pyridiyl Quinolines as Nk3 Receptor Modulators
    Publication number: 20080200504
    Abstract: Compounds of Formula (I) wherein R1, A, R2, R3, R4, R5,n, m and q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
    Type: Application
    Filed: August 9, 2006
    Publication date: August 21, 2008
    Applicant: AstraZeneca AB
    Inventors: Jeffrey S. Albert, Cristobal Alhambra, James Kang, Gerard M. Koether, Thomas R. Simpson, James Woods, Yan Li
  • Quinoline 3-Sulfonate Esters as Nk3 Receptor Modulators
    Publication number: 20080194622
    Abstract: Compounds of Formula I wherein R1, A, R2, R3, R4, R5 n, m and q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
    Type: Application
    Filed: June 21, 2006
    Publication date: August 14, 2008
    Applicant: AstraZeneca AB
    Inventors: Thomas R. Simpson, James Kang, Jeffrey S. Albert, Cristobal Alhambra, Gerard M. Koether, James Woods, Yan Li