Patents by Inventor Gerard Mathis

Gerard Mathis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190202932
    Abstract: The present invention relates to anti-Epidermal Growth Factor Receptor (EGFR) conformational single domain antibodies and uses thereof in particular in the therapeutic and diagnostic field.
    Type: Application
    Filed: March 13, 2019
    Publication date: July 4, 2019
    Inventors: Daniel Baty, Patrick Chames, Damien Nevoltris, Gérard Mathis
  • Patent number: 10287360
    Abstract: The present invention relates to anti-Epidermal Growth Factor Receptor (EGFR) conformational single domain antibodies and uses thereof in particular in the therapeutic and diagnostic field.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: May 14, 2019
    Assignees: INSERM (Institut National de la Santé et de la Recherche Médicale, Université d' Aix-Marseille, Centre National de la Recherche Scientifique (CNRS), CISBIO Bioassays, Institut Jean Paoli & Irene Calmettes
    Inventors: Daniel Baty, Patrick Chames, Damien Nevoltris, Gérard Mathis
  • Patent number: 10174115
    Abstract: The present invention relates to anti-metabotropic glutamate receptor subtype 2 (mGluR2) conformational single domain antibodies and uses thereof in particular in the therapeutic and diagnostic field.
    Type: Grant
    Filed: July 3, 2015
    Date of Patent: January 8, 2019
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, UNIVERSITÉ D'AIX MARSEILLE, UNIVERSITE DE MONTPELLIER, CISBIO BIOASSAYS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT JEAN PAOLI & IRENE CALMETTES, UNIVERSITÉ PARIS-SUD
    Inventors: Daniel Baty, Jean-Philippe Pin, Patrick Chames, Damien Nevoltris, Philippe Rondard, Pauline Scholler, Gérard Mathis
  • Publication number: 20170190787
    Abstract: The present invention relates to anti-Epidermal Growth Factor Receptor (EGFR) conformational single domain antibodies and uses thereof in particular in the therapeutic and diagnostic field.
    Type: Application
    Filed: May 22, 2015
    Publication date: July 6, 2017
    Inventors: Daniel BATY, Patrick CHAMES, Damien NEVOLTRIS, Gérard MATHIS
  • Publication number: 20170145098
    Abstract: The present invention relates to anti-metabotropic glutamate receptor subtype 2 (mGluR2) conformational single do main antibodies and uses thereof in particular in the therapeutic and diagnostic field.
    Type: Application
    Filed: July 3, 2015
    Publication date: May 25, 2017
    Inventors: Daniel BATY, Jean-Philippe PIN, Patrick CHAMES, Damien NEVOLTRIS, Philippe RONDARD, Pauline SCHOLLER, Gérard MATHIS
  • Publication number: 20150198602
    Abstract: The present invention relates to an ex vivo method for determining the susceptibility of a patient suffering from cancer to respond to a therapeutic treatment based on the administration of an antibody specific for the HER2 protein, this method comprising the quantification of HER2-HER2 dimers in a tissue sample from said patient using the FRET technique. The invention also relates to a kit of reagents for implementing this method.
    Type: Application
    Filed: July 16, 2013
    Publication date: July 16, 2015
    Inventors: Fabrice Andre, Herve Bazin, Patrick Garnero, Gerard Mathis
  • Publication number: 20150185150
    Abstract: The subject matter of the invention is a method for measuring the luminescence of a long-life fluorescent compound present in a measuring medium, said medium containing a biological sample, characterized in that it comprises the following steps: a) introduction of a long-life fluorescent compound into the measuring medium, b) introduction, into the measuring medium, of a fluorescent marking agent, the absorption spectrum of which allows the excitation thereof at the same wavelength as that used to excite the long-life fluorescent compound, wherein said emission spectrum allows the measurement of the luminescence thereof at the same wavelength as that used to measure the luminescence of the long-life fluorescent compound, c) excitation of the measuring medium with a wavelength corresponding to an absorption peak of the long-life fluorescent compound, d) measurement of the luminescence emitted by the measuring medium immediately after excitation of said medium, mainly corresponding to the luminescence of the
    Type: Application
    Filed: February 22, 2012
    Publication date: July 2, 2015
    Applicant: CISBIO BIOASSAYS
    Inventors: Gerard Mathis, Herve Bazin
  • Publication number: 20140242611
    Abstract: The invention relates to a method for quantifying a protein of interest expressed at the surface of a cell or else present in a tissue sample, said method comprising the use of two ligands capable of binding specifically to a domain of said protein.
    Type: Application
    Filed: July 4, 2012
    Publication date: August 28, 2014
    Applicant: CISBIO BIOASSAYS
    Inventors: Hervé Bazin, Gérard Mathis
  • Patent number: 8697372
    Abstract: The invention relates to a method for determining whether a test compound binds preferentially to a membrane receptor R1 or to a membrane receptor R2, these receptors being known to be expressed on the surface of the cells in monomeric, homodimeric or heterodimeric form. This method is applied using one or two FRET partner pairs.
    Type: Grant
    Filed: August 12, 2010
    Date of Patent: April 15, 2014
    Assignees: CIS Bio International, Centre National de la Recherche Scientifique
    Inventors: Eric Trinquet, Jurriaan Zwier, Gérard Mathis, Jean-Philippe Pin, Thierry Durroux
  • Patent number: 8663928
    Abstract: Method for the detection in homogeneous medium of a post-translational modification of a proteinaceous substrate catalyzed by a cell enzyme, characterized in that the post-translational modification reaction takes place in intact living cells, in that these cells comprise a heterologous expression vector coding for a fusion protein comprising the proteinaceous substrate and a first coupling domain and in that it comprises the following stages: (i) Incubation of the cells in the presence or in the absence of a compound to be tested capable of modulating the activity of said enzyme, (ii) Addition to the reaction medium of a first fluorescent compound member of a first pair of FRET partners covalently bonded to a coupling agent capable of binding specifically to the first coupling domain present on the proteinaceous substrate, (iii) Addition to the reaction medium of a second fluorescent compound member of this first pair of FRET partners, and covalently bonded to a binding domain specific to the site of the
    Type: Grant
    Filed: November 27, 2007
    Date of Patent: March 4, 2014
    Assignee: CIS BIO International
    Inventors: Eric Trinquet, Achim Brinker, Emmanuel Claret, Gérard Mathis
  • Patent number: 8470523
    Abstract: The invention relates to a quantitative non-microscopic method of detecting intracellular interactions between biomolecules in living cells, in response to a biological or pharmacological stimulation, by a time-resolved proximate energy transfer effect between two members of a fluorescence donor/acceptor pair.
    Type: Grant
    Filed: September 4, 2006
    Date of Patent: June 25, 2013
    Assignee: CIS BIO International
    Inventors: Iris Pribilla, Hervé Bazin, Sraboni Ghose, Norbert Tinel, Michel Fink, Eric Trinquet, Gérard Mathis
  • Patent number: 8361715
    Abstract: The invention relates to a method for suppressing the FRET emitted by a reaction medium containing a pair of fluorescent FRET partner conjugates specific for a biological event, characterized in that a FRET signal killer which does not disturb said biological event is introduced into this medium.
    Type: Grant
    Filed: April 10, 2007
    Date of Patent: January 29, 2013
    Assignee: CIS Bio International
    Inventors: Gérard Mathis, Eric Trinquet, Patrizia Alberti, Michel Laget
  • Publication number: 20120190048
    Abstract: The invention relates to a method for determining whether a test compound binds preferentially to a membrane receptor R1 or to a membrane receptor R2, these receptors being known to be expressed on the surface of the cells in monomeric, homodimeric or heterodimeric form. This method is applied using one or two FRET partner pairs.
    Type: Application
    Filed: August 12, 2010
    Publication date: July 26, 2012
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CIS BIO INTERNATIONAL
    Inventors: Eric Trinquet, Jurriaan Zwier, Gérard Mathis, Jean-Philippe Pin, Thierry Durroux
  • Patent number: 8178704
    Abstract: The present invention relates to inositol phosphate derivatives, in which the inositol phosphate is substituted with one or two reactive groups G or one or two conjugated substances or molecules M, said reactive group(s) G or said substance(s) or molecule(s) M being linked to IP1 via a linkage group L, M being chosen from the following group: a tracer, an immunogen, a member of a binding partner pair, a solid support. Application: tools allowing the study of the inositol phosphate cycle and therefore, indirectly, the study of seven transmembrane domain receptors coupled to phospholipase C, receptors having a tyrosine kinase activity, and in general enzymes involved in the variations of the intracellular concentration of IP1.
    Type: Grant
    Filed: December 2, 2005
    Date of Patent: May 15, 2012
    Assignee: CIS Bio International
    Inventors: Hervé Bazin, Hervé Ansanay, Eric Trinquet, Gérard Mathis
  • Patent number: 7998694
    Abstract: The present invention relates to a method of revealing a biological process using a FRET measurement, which comprises the following steps: incorporating, into a measurement medium containing a lipid membrane, a biological entity X coupled with a first member of a pair of FRET partners and a second biological entity Y coupled with the second member of the pair of FRET partners, the energy-donating member of the pair of FRET partners having a long lifetime and the members of said pair of FRET partners being located on either side of the lipid membrane; exciting the measurement medium at the excitation wavelength of the energy-donating member; and measuring the FRET signal or the variations in said signal emitted in said culture medium.
    Type: Grant
    Filed: August 29, 2006
    Date of Patent: August 16, 2011
    Assignee: CIS BIO International
    Inventors: Eric Trinquet, Hervé Ansanay, Gérard Mathis
  • Patent number: 7872243
    Abstract: The invention concerns the use of the fluorescence polarization phenomenon to improve detection of fluorescent signals during a fluorescence resonance energy transfer (FRET). In particular, the invention concerns a method for improving signal/noise ratio in a FRET measurement. The invention also concerns an apparatus for measuring fluorescence following an energy transfer between a donor fluorescent compound and an acceptor fluorescence compound in a measurement medium.
    Type: Grant
    Filed: June 27, 2005
    Date of Patent: January 18, 2011
    Assignee: CIS BIO International
    Inventors: Eric Trinquet, Gérard Mathis
  • Publication number: 20100086943
    Abstract: Method for the detection in homogeneous medium of a post-translational modification of a protein substrate catalyzed by a cell enzyme, characterized in that the post-translational modification reaction takes place in intact living cells, in that these cells comprise a heterologous expression vector coding for a fusion protein comprising the protein substrate and a first coupling domain and in that it comprises the following stages: (v) Incubation of the cells in the presence or in the absence of a compound to be tested capable of modulating the activity of said enzyme, (vi) Addition to the reaction medium of a first fluorescent compound member of a first pair of FRET partners covalently bonded to a coupling agent capable of binding specifically to the first coupling domain present on the protein substrate, (vii) Addition to the reaction medium of a second fluorescent compound member of this first pair of FRET partners, and covalently bonded to a binding domain specific to the site of the protein substrate hav
    Type: Application
    Filed: November 27, 2007
    Publication date: April 8, 2010
    Applicant: CIS BIO INTERNATIONAL
    Inventors: Eric Trinquet, Achim Brinker, Emmanuel Claret, Gérard Mathis
  • Publication number: 20090294691
    Abstract: The invention concerns the use of the fluorescence polarization phenomenon to improve detection of fluorescent signals during a fluorescence resonance energy transfer (FRET). In particular, the invention concerns a method for improving signal/noise ratio in a FRET measurement. The invention also concerns an apparatus for measuring fluorescence following an energy transfer between a donor fluorescent compound and an acceptor fluorescence compound in a measurement medium.
    Type: Application
    Filed: June 27, 2005
    Publication date: December 3, 2009
    Applicant: CIS BIO INTERNATIONAL
    Inventors: Eric Trinquet, Gerard Mathis
  • Publication number: 20090220988
    Abstract: The present invention relates to a method of revealing a biological process using a FRET measurement, which comprises the following steps: incorporating, into a measurement medium containing a lipid membrane, a biological entity X coupled with a first member of a pair of FRET partners and a second biological entity Y coupled with the second member of the pair of FRET partners, the energy-donating member of the pair of FRET partners having a long lifetime and the members of said pair of FRET partners being located on either side of the lipid membrane; exciting the measurement medium at the excitation wavelength of the energy-donating member; and measuring the FRET signal or the variations in said signal emitted in said culture medium.
    Type: Application
    Filed: August 29, 2006
    Publication date: September 3, 2009
    Inventors: Eric Trinquet, Hervè Ansanay, Gérard Mathis
  • Publication number: 20090215106
    Abstract: The present invention relates to a quantitative non-microscopic method of detecting intracellular interactions between biomolecules, on living cells, in response to a biological or pharmacological stimulation, by a time-resolved proximate energy transfer effect between two members of a fluorescence donor/acceptor pair.
    Type: Application
    Filed: September 4, 2006
    Publication date: August 27, 2009
    Inventors: Iris Pribilla, Herve Bazin, Sraboni Ghose, Norbert Tinel, Michel Fink, Eric Trinquet, Gerard Mathis